Low level laser therapy versus benzydamin in prevention and treatment of oral mucositis induced by anticancer treatments (clinical and biochemical study)

Mohamed, Nashwa Helaly; Kamel, Asem; Edress, Mohamed Fouad; Mahmoud, Azza Shibl Sayed; Gaafar, Ashraf I.

doi:10.4322/bds.2022.e3406

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…Ionization irradiation causes local infection, suture dehiscence, and mucositis [12,17,18]. In the present study, alopecia, ulceration and radiodermatitis were observed.…”

Section: Discussionsupporting

confidence: 57%

Effect of radiotherapy on the differentiation and osteogenic activity of mesenchymal stem cells on dental implants

et al. 2023

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Objective: to evaluate the differentiation and gene expression of transcripts related to osteogenesis in a primary culture of Mesenchymal Stem Cells (MSCs) derived from rat femurs submitted to radiotherapy and the installation of pure titanium implants. Material and Methods: fifty-four rats received titanium implants in both femurs and were divided into three groups: Control: implant surgery (C); Implant + immediate irradiation (IrI), and Implant + late irradiation (IrL). Euthanasia occurred 3, 14, and 49 days after surgery. The bone marrow MSCs from the femurs were isolated and cultivated. The cell viability, total protein content, alkaline phosphatase (ALP) activity, and the formation of mineralization nodules and cellular genotoxicity were analyzed. The gene expression of Alkaline Phosphatase (phoA), Collagen 1 (COL1), Runt-related transcription factor 2 (RUNX2), Osterix (OSX), Osteopontin (OPN), Integrin β 1 (ITGB 1 ), Bone Sialoprotein (BSP), Osteonectin (SPARC), Osteocalcin (Bglap), Transforming Growth Factor β-type (TGF-β), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interleukin-6 (IL-6), Apolipoprotein E (APOE) and Prostaglandin E 2 synthase (PGE 2 ) were evaluated by qRT-PCR. Results: ionizing radiation suppresses the gene expression of essential transcripts for bone regeneration, as well as cellular viability, as observed in the IrI and IrL groups. Conclusion: although this can lead to the loss of osseointegration and failure of the implant, the MSCs showed more activity at 49 days than at 3 and 14 days.

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“…Ionization irradiation causes local infection, suture dehiscence, and mucositis [12,17,18]. In the present study, alopecia, ulceration and radiodermatitis were observed.…”

Section: Discussionsupporting

confidence: 57%

Effect of radiotherapy on the differentiation and osteogenic activity of mesenchymal stem cells on dental implants

et al. 2023

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“…Table 3 presents detailed information on the descriptive characteristics of the included studies, such as authors, year of publication, type of study, sample size, OM assessment scale and associated pain, degree of mucositis, oral hygiene habits; and laser characteristics, such as energy density, wavelength and power. Among the articles included, there are seven clinical trials [4,[11][12][13][14][15][16] and two pilot studies [17,18].…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

“…Sample sizes in the studies ranged from 16 to 85 patients, aged between 10 months and 18 years. To assess the degree of OM, seven studies [11][12][13][14][16][17][18] used the World Health Organization (WHO) scale, while only two studies [4,15] used the toxicity criteria recommended by the National Cancer Institute (NCI).…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

“…Patients' pain measurements were based on studies by Cauwels and Martens [17]; Amadori et al [11]; Guimaraes et al [14]; Mohamed et al [15]; Reyad et al [16] on the Visual Analog Scale (VAS). On the other hand, the study by Ribeiro da Silva et al [18], the Children's International Mucositis Evaluation Scale (ChIMES) was used, while in the study by Gobbo et al (2018), the analysis was performed using the Numeric Rating Scale (NRS) and, in one of the studies, pain measurement was not addressed [4].…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

“…The toothbrushing habit was guided by six of the included studies [4,11,[15][16][17][18]. Two studies did not report encouraging toothbrushing [13,14] and only one of the articles did not include an assessment of oral health status in study design [12,15,16].…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

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Influence of low-level laser on oral mucositis treatment in young cancer patients undergoing chemotherapy: a systematic review

DINIZ,

FELÍCIO,

GUIMARÃES

2023

RGO, Rev. Gaúch. Odontol.

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Perform a systematic review of the literature to seek scientific evidence on the effect of low-level laser therapy on duration, degree and pain of chemotherapy-induced oral mucositis in young patients with cancer. Methods: A bibliographic search was performed using the PubMed, Scopus and Web of Science databases to identify relevant scientific studies, found through the descriptors “laser therapy”, “phototherapy”, “oral mucositis”, “pediatric patient” and “children” to evaluate this association. Information regarding the degree of mucositis, pain associated with patients, toothbrushing and laser were analyzed characteristics. Results: Of the nine studies, one did not obtain significant results on the healing action of LLLT on oral mucositis and of the eight remaining studies, 83. 3% showed significant evidence of a decrease in the degree of oral mucositis and consequently its duration. With regard to pain, 100% of the studies confirmed its decrease. Conclusion: Low-level laser therapy is considered an efficient instrument for the treatment of oral mucositis on young patients with cancer due to its analgesic, anti-inflammatory and healing effects.

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Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

et al. 2023

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Benzydamine is a non-steroidal anti-inflammatory drug with distinct pharmacological properties from other compounds in the same therapeutic class. The differences are structural and pharmacological in nature; the anti-inflammatory mechanism is not strictly explained by the ability to interfere with the synthesis of prostaglandins. The compound is used strictly in local inflammatory diseases (inflammation in the oral and vaginal mucosa). In addition to the therapeutic indications found in the summary of product characteristics (SPC), the compound is used, in high doses, as a psychotropic substance for oral administration, having similar properties to lysergic acid diethylamide (LSD). As an over-the-counter (OTC) compound, it is easy to obtain, and the consequences of using it for purposes other than those assumed by the manufacturer raise various concerns. The reasons are related to the pharmacodynamic and pharmaco-toxicological properties, since neither the mechanism of action nor the possible side effects that would result from systemic consumption, in high doses, even occasionally, have been fully elucidated. The present review aims to analyze the pharmacodynamic properties of benzydamine, starting from the chemical structure, by comparison with structurally similar compounds registered in therapy (as an anti-inflammatory or analgesic) or used for recreational purposes.

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Low level laser therapy versus benzydamin in prevention and treatment of oral mucositis induced by anticancer treatments (clinical and biochemical study)

Abstract: Low level laser therapy versus benzydamin in prevention and treatment of oral mucositis induced by anticancer treatments (clinical and biochemical study)Terapia a laser de baixa intensidade versus benzidamina na prevenção e tratamento da mucosite oral induzida por terapia oncológica

Cited by 3 publications

References 25 publications

Effect of radiotherapy on the differentiation and osteogenic activity of mesenchymal stem cells on dental implants

Effect of radiotherapy on the differentiation and osteogenic activity of mesenchymal stem cells on dental implants

Influence of low-level laser on oral mucositis treatment in young cancer patients undergoing chemotherapy: a systematic review

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

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