Low-Level Laser Therapy with 670 nm Alleviates Diabetic Retinopathy in an Experimental Model

Abdelkawi, Salwa Ahmed; Ghoneim, Dina Fouad; Morsy, Mona E.; Hassan, Aziza Ahmed; Mahmoud, Abdel Rahman Hassan

doi:10.4103/joco.joco_29_20

Cited by 8 publications

(4 citation statements)

References 63 publications

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“…A total of 6 studies were conducted, including 4 studies on preclinical models ( 64 – 67 ) and 2 studies in humans ( 68 , 69 ) ( Table 3 ). Preclinical studies consistently reported a positive effect of PBM on retinal structure associated with a decrease in oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Perrier,

Moro,

Lablanche

2024

Front. Endocrinol.

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IntroductionDiabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation.MethodsThis review evaluates preclinical and clinical studies exploring the potential of PBM in diabetes and its complications, as well all clinical trials, both planned and completed, available on ClinicalTrials database.ResultsThis review highlights the variability in PBM parameters across studies, hindering consensus on optimal protocols. Standardization of treatment parameters and rigorous clinical trials are needed to unlock PBM’s full therapeutic potential. 87 clinical trials were identified that investigated PBM in diabetes mellitus (with 5,837 patients planned to be treated with PBM). Clinical trials assessing PBM effects on diabetic neuropathy revealed pain reduction and potential quality of life improvement. Studies focusing on wound healing indicated encouraging results, with PBM enhancing angiogenesis, fibroblast proliferation, and collagen density. PBM’s impact on diabetic retinopathy remains inconclusive however, requiring further investigation. In glycemic control, PBM exhibits positive effects on metabolic parameters, including glucose tolerance and insulin resistance.ConclusionClinical studies have reported PBM-induced reductions in fasting and postprandial glycemia without an increased hypoglycemic risk. This impact of PBM may be related to its effects on the beta cells and islets in the pancreas. Notwithstanding challenges, PBM emerges as a promising adjunctive therapy for managing diabetic neuropathy, wound healing, and glycemic control. Further investigation into its impact on diabetic retinopathy and muscle recovery is warranted.

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Section: Resultsmentioning

confidence: 99%

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Perrier,

Moro,

Lablanche

2024

Front. Endocrinol.

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“…Determination of ROS was performed using colorimetric assays, each according to the manufacturer's instructions (Appendix S1). The oxidative stress index (MDA/TAC ratio) was then obtained by dividing the values of MDA (μmol/L) by TAC (mmol/L) (Ahmed et al, 2021; Badehnoosh et al, 2018; Dash et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

Photo‐excitable zinc sulfide nanoparticles: A theranostic nanotool for cancer management

et al. 2022

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ObjectivesZinc sulfide nanoparticles (ZnS NPs), as one of the quantum dots less than 10 nm, possess unique size‐dependent autofluorescence. Excitation of their valence electrons by energy higher than the bandgap reveals the ZnS NPs' inherited photocatalysis with additive cytotoxic consequences of reactive oxygen species (ROS) release. Coupling the cytotoxicity of photoactivated ZnS NPs with their autofluorescence would be a novel theranostic modality, combating superficially accessible carcinoma.Material and methodsAfter synthesizing and characterization of ZnS NPs, we verified their photocatalysis and electron donation upon UV excitation in degrading organic dye and DNA cleavage, respectively. We then tested the efficacy of UV‐activated ZnS NPs to induce ROS‐dependent apoptosis in squamous cell carcinoma and breast cancer cell lines.ResultsThe energetic electron–hole pairs generated upon UV excitation of ZnS NPs with the consequent cascade of ROS release revealed potent apoptotic cancer cell deaths, compared with single treatment modalities of nonexcited nanoparticles and UV. Moreover, the inherited luminescence of ZnS NPs enabled visualization of their predominant intracytoplasmic uptake with tracking of their cellular response.ConclusionThe intensified luminescence and the fortified cytotoxicity of photoactivated ZnS NPs enhance their theranostic qualifications, boosting their antitumorigenic use.

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“…3LT showed promising results for myocardial function [87], mesenchymal stem cell regeneration [88], skin injuries [89-92], brain trauma, TBI [93-96], diabetic retinopathy [97], oncology [98], and more.…”

Section: Physical Characteristics Of Low Power/cold Laser Toolmentioning

confidence: 99%

Early trauma, brain development, and a novel therapeutic approach

Friedman

2024

Neuropediatrics - Recent Advances and Novel Therapeutic Approaches

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Trauma can result from an event that is perceived as life-threatening or as having the potential of seriously harming oneself or others. Such experiences, often accompanied by intense fear, terror, and helplessness, can lead to the development of PTSS and PTSD. Response to trauma depends on trauma feature characteristics and specific personal factors. In clinical literature, PTSD is often accompanied by severe functional impairment and includes well-described symptoms. These create behavior that limits the person and causes functional damage over time. Moreover, PTSS in early age may lead to adverse structural and functional changes in the development of brain neural circuits. PTSD has been one of the most investigated themes in medicine, psychiatry, neurophysiology, and rehabilitation over the last years. HPA axis, neural inflammation, and the neural mitochondrial oxidative stress are involved in the molecular mechanism of PTSD, reducing neuroplasticity and synapse proliferation. Here, current data on PTSD causes and symptoms, and the mechanisms and functions of the mitochondrial stress response, are reviewed, leading to 3LT novel scientifically and clinically based therapeutic approach. 3LT tool, aimed to the neural molecular mechanism of PTSS, targets mitochondrial dysfunction for the prevention and correction of neural lesions associated with PTSD.

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Low-Level Laser Therapy with 670 nm Alleviates Diabetic Retinopathy in an Experimental Model

Cited by 8 publications

References 63 publications

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Photo‐excitable zinc sulfide nanoparticles: A theranostic nanotool for cancer management

Early trauma, brain development, and a novel therapeutic approach

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