Low-level lead exposure changes endothelial modulation in rat resistance pulmonary arteries

Covre, Emilia Polaco; Freire, David D.; Dalfior, Bruna Miurim; Marques, Vinícius Bermond; Ribeiro, Rogério Faustino; Carneiro, Maria Tereza Weitzel Dias; Santos, Leonardo dos

doi:10.1016/j.vph.2016.07.002

Cited by 10 publications

(2 citation statements)

References 39 publications

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“…They concluded that short-term and low-level exposure to Pb changes pulmonary hemodynamics and increases oxidative stress since vasodilatation to exogenous NO was reduced by Pb. [ 119 ] More importantly, these studies have elucidated the cellular and molecular mechanisms of Pb action on cardiovascular/pulmonary systems, but a comprehensive strategy to prevent deaths from CVD should include efforts to reduce lead exposure.…”

Section: Heavy Metal Pollution and Endothelial Dysfunctionmentioning

confidence: 99%

Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction

et al. 2023

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During the last two decades, large epidemiological studies have shown that the physical environment, including noise, air pollution or heavy metals, have a considerable impact on human health. It is known that the most common cardiovascular risk factors are all associated with endothelial dysfunction. Vascular tone, circulation of blood cells, inflammation, and platelet activity are some of the most essential functions regulated by the endothelium that suffer negative effects as a consequence of environmental pollution, causing endothelial dysfunction. In this review, we delineate the impact of environmental risk factors in connection to endothelial function. On a mechanistic level, a significant number of studies suggest the involvement of endothelial dysfunction to fundamentally drive the adverse endothelium health effects of the different pollutants. We focus on well-established studies that demonstrate the negative effects on the endothelium, with a focus on air, noise, and heavy metal pollution. This in-depth review on endothelial dysfunction as a consequence of the physical environment aims to contribute to the associated research needs by evaluating current findings from human and animal studies. From a public health perspective, these findings may also help to reinforce efforts promoting the research for adequate promising biomarkers for cardiovascular diseases since endothelial function is considered a hallmark of environmental stressor health effects.

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Section: Heavy Metal Pollution and Endothelial Dysfunctionmentioning

confidence: 99%

Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction

et al. 2023

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“…Although there was an increase in NO, the vascular smooth muscle did not respond adequately to the increased NO, indicating a dysfunction in the vasodilatory response. There is a need to evaluate the mechanism of NO resistance in the pulmonary vessels 90 . As discussed by Bhatnagar 5 and Briffa, et al 6 , chronic Pb exposure is associated with decreased NO availability, thus disrupting the endothelial cell signaling mechanisms responsible for vasodilation.…”

Section: Metals and Phmentioning

confidence: 99%

Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension

Hopkins,

Wessel,

Chen

et al. 2023

Int. J. Biol. Sci.

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Pulmonary and systemic hypertension (PH, SH) are characterized by vasoconstriction and vascular remodeling resulting in increased vascular resistance and pulmonary/aortic artery pressures. The chronic stress leads to inflammation, oxidative stress, and infiltration by immune cells. Roles of metals in these diseases, particularly PH are largely unknown. This review first discusses the pathophysiology of PH including vascular oxidative stress, inflammation, and remodeling in PH; mitochondrial dysfunction and metabolic changes in PH; ion channel and its alterations in the pathogenesis of PH as well as PH-associated right ventricular (RV) remodeling and dysfunctions. This review then summarizes metal general features and essentiality for the cardiovascular system and effects of metals on systemic blood pressure. Lastly, this review explores non-essential and essential metals and potential roles of their dyshomeostasis in PH and RV dysfunction. Although it remains early to conclude the role of metals in the pathogenesis of PH, emerging direct and indirect evidence implicates the possible contributions of metal-mediated toxicities in the development of PH. Future research should focus on comprehensive clinical metallomics study in PH patients; mechanistic evaluations to elucidate roles of various metals in PH animal models; and novel therapy clinical trials targeting metals. These important discoveries will significantly advance our understandings of this rare yet fatal disease, PH.

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Personal exposure to PM2.5 constituents associated with gestational blood pressure and endothelial dysfunction

Xia

Zhou

Zhu

et al. 2019

Environmental Pollution

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Low-level lead exposure changes endothelial modulation in rat resistance pulmonary arteries

Cited by 10 publications

References 39 publications

Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction

Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction

Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension

Personal exposure to PM2.5 constituents associated with gestational blood pressure and endothelial dysfunction

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