2010
DOI: 10.1002/jmv.21821
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Low level myocardial parvovirus B19 persistence is a frequent finding in patients with heart disease but unrelated to ongoing myocardial injury

Abstract: While myocardial parvovirus B19 (B19V), aside from enteroviruses (EV) and adenoviruses (ADV), has recently been found often in patients with myocarditis and idiopathic dilated cardiomyopathy (IDC), the pathogenetic significance of B19V genomes in those patients has not yet been sufficiently elucidated. In the present study, left ventricular endomyocardial biopsies from 24 patients with left ventricular ejection fraction (LVEF) below 55% due to IDC, and tissue from the right atrial appendage of 10 control patie… Show more

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Cited by 51 publications
(39 citation statements)
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“…Its particular tropism for myocardium and liver, here reported, suggests to further study the possible role of PARV4 infection in heart and liver diseases, considering also that PARV4 infection has been frequently detected in HCV infected patients. It is to note that also B19V is frequently detectable in liver and myocardial tissue both in acute and persistent B19V infection and its importance in liver and heart diseases still remains unclear [17-21]. …”
Section: Discussionmentioning
confidence: 99%
“…Its particular tropism for myocardium and liver, here reported, suggests to further study the possible role of PARV4 infection in heart and liver diseases, considering also that PARV4 infection has been frequently detected in HCV infected patients. It is to note that also B19V is frequently detectable in liver and myocardial tissue both in acute and persistent B19V infection and its importance in liver and heart diseases still remains unclear [17-21]. …”
Section: Discussionmentioning
confidence: 99%
“…30,31 Interestingly, although there are clear associations between the presence of viral genomes within the myocardium and cardiac dysfunction, the presence of virus does not predict whether a particular individual will develop chronic HF. [25][26][27]32,33 It is unclear why a subset of patients with severe viral myocarditis and LV dysfunction develop chronic HF, whereas others fully recover. However, host susceptibility has been hypothesized to play a role.…”
Section: Myocarditis: the Viral Perspectivementioning
confidence: 99%
“…In particular, the definition of a possible role of B19V in the development of chronic cardiomyopathies and cardiac dysfunction is a matter of ongoing debate. Correlation between B19V and cardiomyopathies, in particular dilated cardiomyopathy and ventricular dysfunction, has been proposed by several studies comparing selected groups of patients versus controls [197][198][199][200][201][202][203][204][205], but on the opposite, a lack of significant clinical association has been supported by other groups [206][207][208][209][210][211][212].…”
Section: Cardiomyopathiesmentioning
confidence: 99%