Low-Level Nighttime Light Therapy for Age-Related Macular Degeneration: A Randomized Clinical Trial

Robinson, Denise; Margrain, Thomas Hengist; Dunn, Matthew; Bailey, Clare; Binns, Alison

doi:10.1167/iovs.18-24284

Cited by 12 publications

(11 citation statements)

References 62 publications

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“…As darkness is known to stimulate the secretion of melatonin from the pineal gland, our findings are in agreement with previous studies showing that increased melatonin synthesis could play a protective role in the pathophysiology of AMD 67 . However, a recent randomized controlled trial (RCT) failed to show any beneficial effect of low-level night-time light therapy on the progression of AMD 68 .…”

Section: Resultsmentioning

confidence: 99%

Sleep, pain, and neurodegeneration: A Mendelian randomization study

Grover

Sharma

2021

Preprint

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Objective To examine whether sleep and pain-related traits have a causal effect on the risk of neurodegeneration. Design Two-sample Mendelian randomization using an inverse-variance weighted (IVW) estimate of the summary effect estimates. Setting Genetic data on sleep and pain-related traits and neurodegenerative disorders (NDD) from various cohorts comprising individuals predominantly of European ancestry. Participants Participants from the International Sleep Genetic Epidemiology Consortium (ISGEC), UK Biobank sleep and chronotype research group, International Genomics of Alzheimer's patients (IGAP), project MinE, International Age-related Macular Degeneration Consortium (IAMDGC), International Multiple Sclerosis Genetics Consortium (IMSGC), International Parkinson's Disease Genomics Consortium (IPDGC) Exposures Self-reported chronotype (CHR), morning preference (MP), insomnia symptoms (INS), sleep duration (SP), short sleep (SS), long sleep (LS), and multisite chronic pain (MCP) Main outcome measures Age-related macular degeneration (AMD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), Multiple sclerosis (MS), and Parkinson's disease (PD) Results We considered a threshold of P=0.00142 as significant accounting for multiple testing, and P<0.05 was considered to be suggestive evidence for a potential association. Using direct MR, MP was observed as the strongest risk factor for AMD (ORIVW = 1.19, 95% CI 1.08, 1.32, P = 0.00073). We observed suggestive evidence of influence of different sleep traits on neurodegeneration: CHR on AMD (ORIVW = 1.27, 95% CI 1.08, 1.49, P = 0.0034), SS on AD (ORIVW 1.26, 95% CI 1.08, 1.46, P = 0.0044), and INS on ALS (ORIVW 1.55, 95% CI 1.12, 2.14, P = 0.0123). The association of SS with AD was, however, lost after the exclusion of overlapping UKB samples. Using pain as exposure, our study failed to observe any role of pain in neurodegeneration. Results were largely robust to reverse causal analyses and sensitivity analyses accounting for horizontal pleiotropy. Conclusions Our study highlighted the role of morning preference as a risk factor for AMD and provided suggestive evidence of different sleep traits on a wide spectrum of neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 99%

Sleep, pain, and neurodegeneration: A Mendelian randomization study

Grover

Sharma

2021

Preprint

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“…Dimitrov et al [15,41] assessed using both techniques. Eight studies used an adapted Humphrey Visual Field Perimeter (HVFP; Carl Zeiss Meditec, Inc, Dublin, CA, USA) [43][44][45][46][47][48][49][50] and eight utilised an 'in-house' adaptometer, with methods developed by investigators [15,41,42,[61][62][63][64][65]. Other adaptometers, featured in more than one study, included the Medmont Dark Adapted Chromatic perimeter (MDAC; Medmont Pty Ltd, Melbourne, Australia) (5 out of 27 studies) [55][56][57][58][59] and the Macular Disease Detection MDD-2 Ò device (Health Research Science, LLC, Lighthouse Pt, FL, USA) (2 out of 27 studies) [53,54].…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

“…The most frequently reported parameters of DA in studies that did not use the AdaptDx were RCB (10 out of 27 studies) [41, 42, 44-48, 60, 63, 65], cone absolute threshold (9 out of 27 studies) [41, 42, 44-48, 63, 65], cone time constant (8 out of 27 studies) [44][45][46][47][48][49][50]65] and RIT/ rod criterion time (7 out of 27 studies) [41,[55][56][57][58][59]63]. Other parameters in the reviewed papers included rod absolute threshold (5 out of 27 studies) [41,[46][47][48]63] and 'second slope' or rod slope (5 out of 27 studies) [42,[46][47][48]65], which refers to the second phase of rod recovery when threshold data are fitted with a model based on the physiological process of DA [7].…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

“…To examine cone-mediated DA, frequently reported stimulus wavelengths of * 620 nm [55,56] or 650 nm [47,48] were seen in the literature. Eight studies used a threshold location of 12°eccentricity [46][47][48][55][56][57][58][59], seven studies used a 5.5-6°l ocation [42,[55][56][57][58][59]65], seven studies used an 3.5-4°location [15,41,[55][56][57][58][59], six studies used a foveal location [41,44,45,49,50,63], five studies used an 8°location [55][56][57][58][59] and two studies used a 3°location [42,65].…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

“…The National Eye Institute Visual Function Questionnaire (NEI VFQ) [48,51,61,62], Veterans Affairs Low Vision Visual Function Questionnaire (VFQ-48) [49], the EuroQol-5D Instrument (EQ-5D) [49] and Pittsburgh Sleep Quality Index (PSQI) [49] also featured in the literature but were not compared to DA metrics.…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

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Are Current Methods of Measuring Dark Adaptation Effective in Detecting the Onset and Progression of Age-Related Macular Degeneration? A Systematic Literature Review

et al. 2021

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Introduction: Dark adaptation (DA) has been proposed as a possible functional biomarker for age-related macular degeneration (AMD). In this systematic review we aim to evaluate current methodology used to assess DA in people with AMD, the evidence of precision in detecting the onset and progression of AMD, and the relationship between DA and other functional and structural measures. Methods: MEDLINE, EMBASE, CINAHL, AMED, PsycINFO, PsycARTICLES were searched for studies published between January 2006 and January 2020 that assessed DA in people with AMD. Details of eligible studies including study design, characteristics of study population and outcomes were recorded. All included studies underwent quality appraisal using approved critical appraisal tools. This systematic review follows PRISMA guidelines (PROSPERO registration number: CRD42019129486). Results: Forty-eight studies were eligible for inclusion, reporting a variety of instruments and protocols to assess different DA parameters. Twenty of these studies used the AdaptDx (MacuLogix, Hummelstown, PA, USA) instrument and assessed rod-intercept time (RIT). Most of these reported that RIT was delayed in people with AMD and this delay worsened with AMD severity. Four studies, involving 533 participants, reported estimates of diagnostic performance of AdaptDx to separate people with AMD from visually healthy controls. DA has been compared to other measures of visual function, patient-reported outcome measures (PROMs) and structural measures. Ten studies specifically considered evidence that the presence of certain structural abnormalities was associated with impaired DA in AMD. Conclusions: This systematic review indicates overwhelming evidence of reasonable quality for an association between impaired DA and AMD. Data on the repeatability and reproducibility of DA measurement are sparse. There is evidence that structural abnormalities such as reticular drusen are associated with prolongation of DA time. Fewer studies have explored an association between DA and other measures of visual function or PROMs. We found no studies that had compared DA with performance-based measures.

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Low vision rehabilitation for better quality of life in visually impaired adults

Nispen

Virgili

Hoeben

et al. 2020

Cochrane Database of Systematic Reviews

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Analysis 1.1. Comparison 1 Low vision rehabilitation versus waiting list or no care, Outcome 1 Health-related quality of life....... Analysis 1.2. Comparison 1 Low vision rehabilitation versus waiting list or no care, Outcome 2 Vision-related quality of life........ Analysis 1.3. Comparison 1 Low vision rehabilitation versus waiting list or no care, Outcome 3 Activities of daily living (QOL physical aspect

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Low-Level Nighttime Light Therapy for Age-Related Macular Degeneration: A Randomized Clinical Trial

Abstract: Although acceptable to the patients, light therapy did not have a substantial effect on the progression of early AMD over 12 months. Further investigation is necessary to discover the permanency and cause of the adverse effect of light therapy on dark adaptation.

Cited by 12 publications

References 62 publications

Sleep, pain, and neurodegeneration: A Mendelian randomization study

Sleep, pain, and neurodegeneration: A Mendelian randomization study

Are Current Methods of Measuring Dark Adaptation Effective in Detecting the Onset and Progression of Age-Related Macular Degeneration? A Systematic Literature Review

Low vision rehabilitation for better quality of life in visually impaired adults

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