Low-Level Prenatal Lead Exposure Alters Auditory Recognition Memory in 2-Month-Old Infants: An Event-Related Potentials (ERPs) Study

Geng, Fengji; Mai, Xiaoqin; Zhan, Junpeng; Xu, Lin; Shao, Jie; Meeker, John D.; Lozoff, Betsy

doi:10.1080/87565641.2014.959172

Cited by 14 publications

(11 citation statements)

References 42 publications

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“…There were only low-order correlations between ZPP/H and SF ( r = −0.15, p = 0.10) or Pb ( r = −0.17, p = 0.07). However, in light of iron-Pb physiologic interactions and important effects of Pb on neurodevelopment, including memory,(12, 22, 23) Pb was included as an additional covariate.…”

Section: Resultsmentioning

confidence: 99%

“…Specific entrance criteria included singleton birth with gestational age ≥ 37 weeks, birth weight ≥ 2,500 g, 5-minute Apgar score ≥7, no use of antibiotics (an indirect measure of confirmed or suspected infection), no placental abruption or uterine rupture, no birth injury or congenital deficits, no hemolytic or metabolic diseases, and normal hearing. (12) The majority of infants lived in 2-parent households. Most parents had completed high school; 32.5% of the infants had at least one parent who completed college.…”

Section: Methodsmentioning

confidence: 99%

“…This testing lasted about 12 minutes. More details of this task can be found in our previous publications (12, 21). …”

Section: Methodsmentioning

confidence: 99%

“…Preprocessing and data reduction were carried out in Net Station 4.4 (Eugene, OR) including filtering, segmentation, artifacts detection, data rejection, interpolation, and re-reference. More information on ERP recording measurements and preprocessing steps were included in our previous publications (12, 21). …”

Section: Methodsmentioning

confidence: 99%

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Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age

Geng

Mai

Zhan

et al. 2015

The Journal of Pediatrics

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Objective To assess the effects of fetal-neonatal iron deficiency on recognition memory in early infancy. Perinatal iron deficiency delays or disrupts hippocampal development in animal models and thus may impair related neural functions in human infants, such as recognition memory. Study design Event-related potentials were used in an auditory recognition memory task to compare 2-month-old Chinese infants with iron sufficiency or deficiency at birth. Fetal- neonatal iron deficiency was defined two ways: high zinc protoporphyrin/heme ratio (ZPP/H > 118 μmol/mol) or low serum ferritin (< 75 μg/l) in cord blood. Late slow wave (LSW) was used to measure infant recognition of mother’s voice. Results ERP patterns differed significantly for fetal-neonatal iron deficiency as defined by high cord ZPP/H but not low ferritin. Comparing 35 infants with iron deficiency (ZPP/H > 118 μmol/mol) to 92 with lower ZPP/H (iron-sufficient), only infants with iron sufficiency showed larger LSW amplitude for stranger’s voice than mother’s voice in frontal-central and parietal-occipital locations, indicating the recognition of mother’s voice. Conclusions Infants with iron sufficiency showed electrophysiological evidence of recognizing their mother’s voice, whereas infants with fetal-neonatal iron deficiency did not. Their poorer auditory recognition memory at two months of age is consistent with effects of fetal-neonatal iron deficiency on the developing hippocampus.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…This testing lasted about 12 minutes. More details of this task can be found in our previous publications (12, 21). …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age

Geng

Mai

Zhan

et al. 2015

The Journal of Pediatrics

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“…109 Even low levels of lead are related to worse performance on cognitive tasks and reduced auditory recognition ability. 110,111 Similarly, environmental tobacco smoke has greater effects on children's cognitive outcomes among children from lower SES backgrounds relative to their higher SES peers. 112 …”

Section: Environmental Toxinsmentioning

confidence: 99%

State of the Art Review: Poverty and the Developing Brain

2016

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In the United States, >40% of children are either poor or near-poor. As a group, children in poverty are more likely to experience worse health and more developmental delay, lower achievement, and more behavioral and emotional problems than their more advantaged peers; however, there is broad variability in outcomes among children exposed to similar conditions. Building on a robust literature from animal models showing that environmental deprivation or enrichment shapes the brain, there has been increasing interest in understanding how the experience of poverty may shape the brain in humans. In this review, we summarize research on the relationship between socioeconomic status and brain development, focusing on studies published in the last 5 years. Drawing on a conceptual framework informed by animal models, we highlight neural plasticity, epigenetics, material deprivation (eg, cognitive stimulation, nutrient deficiencies), stress (eg, negative parenting behaviors), and environmental toxins as factors that may shape the developing brain. We then summarize the existing evidence for the relationship between child poverty and brain structure and function, focusing on brain areas that support memory, emotion regulation, and higher-order cognitive functioning (ie, hippocampus, amygdala, prefrontal cortex) and regions that support language and literacy (ie, cortical areas of the left hemisphere). We then consider some limitations of the current literature and discuss the implications of neuroscience concepts and methods for interventions in the pediatric medical home.

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Signatures of emotional face processing measured by event‐related potentials in 7‐month‐old infants

Aran

Garcia

Hankin

et al. 2022

Developmental Psychobiology

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The ability to distinguish facial emotions emerges in infancy. Although this ability has been shown to emerge between 5 and 7 months of age, the literature is less clear regarding the extent to which neural correlates of perception and attention play a role in processing of specific emotions. This study's main goal was to examine this question among infants. To this end, we presented angry, fearful, and happy faces to 7-monthold infants (N = 107, 51% female) while recording event-related brain potentials. The perceptual N290 component showed a heightened response for fearful and happy relative to angry faces. Attentional processing, indexed by the P400, showed some evidence of a heightened response for fearful relative to happy and angry faces. We did not observe robust differences by emotion in the negative central (Nc) component, although trends were consistent with previous work suggesting a heightened response to negatively valenced expressions. Results suggest that perceptual (N290) and attentional (P400) processing is sensitive to emotions in faces, but these processes do not provide evidence for a fear-specific bias across components.

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Low-Level Prenatal Lead Exposure Alters Auditory Recognition Memory in 2-Month-Old Infants: An Event-Related Potentials (ERPs) Study

Cited by 14 publications

References 42 publications

Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age

Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age

State of the Art Review: Poverty and the Developing Brain

Signatures of emotional face processing measured by event‐related potentials in 7‐month‐old infants

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