Since most people spend more time at work in recent times, this has led to more workplace issues and health problems. The well‐being of occupants and their overall health are strongly impacted by factors that determine the standard of indoor environments. These factors include the air quality, the level of thermal comfort, the inclusion of indoor plants, the admission of daylighting, and a variety of other factors. The absence of any of these may result in sick building syndrome (SBS). Therefore, well‐planned indoor workspaces are vital for occupants’ health and productivity at work. The aim of this article is to investigate proactive measures for mitigating SBS in office buildings located within universities in the United Kingdom. The study administered a questionnaire to gather perceptions of office occupants, followed by a comparative case study analysis of two office buildings at the University of Greenwich located on different campuses to highlight the correlation among the physical parameters of indoor office spaces and the occurrence of SBS. The results showed that a notable percentage of participants reported experiencing at least two symptoms of SBS. This study provided clear evidence that symptoms of SBS are primarily associated with the physical characteristics of the building, and these elements significantly influence the occupants’ experiences. The mitigation of potential adverse effects on the well‐being of inhabitants during the operating phase of a building resulting from physical variables can be achieved by the implementation of conscious design considerations during the initial planning stages of future buildings. One of the practical implications of this study is that it raises the urgency for built environment professionals to be fully aware of how their design decisions could either contribute to or prevent SBS symptoms.