Low Levels of 25-hydroxyvitamin D<sub>3</sub>and 1,25-dihydroxyvitamin D<sub>3</sub>in Patients with Newly Diagnosed Type 1 Diabetes

Pozzilli, Paolo; Manfrini, Silvia; Crinò, Antonino; Picardi, Antonio; Leomanni, C; Cherubini,; Valente, L; Khazrai, Yeganeh Manon; Visalli, N

doi:10.1055/s-2005-870578

Cited by 182 publications

(151 citation statements)

References 9 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of vitamin D deficiency was 43% in an Australian study [19], about 25% in an Italian study [21] and 15% in a recent study in US East Coast youth [20]. However, when focusing on the prevalence of vitamin D sufficiency, the data were similar: Bern: 13%; Australia: 19%; US East coast: 25%.…”

Section: Discussionmentioning

confidence: 90%

“…In addition, low serum vitamin D levels are associated with a higher fracture risk in elderly people [3]. Furthermore, vitamin D deficiency is common in healthy children at a variety of different latitudes [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] and in children with type 1 diabetes mellitus (T1D), in whom the highly variable prevalence ranges between 15-65% at the end of winter [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

Janner

Flueck

Mullis

2009

Bone

View full text Add to dashboard Cite

SummaryBackground: Vitamin D is important for bone health. An inadequate supply of vitamin D to the body is associated with a higher fracture risk in the elderly. Young adults with type 1 diabetes are reported to have a lower peak bone mass than healthy individuals, which could possibly lead to an increased fracture risk in the future. The prevalence of vitamin D deficiency in healthy young people is high. Thus, optimal supply of vitamin D may be of particular importance for bone health in children with type 1 diabetes.Methods: In this prospective cross-sectional study we measured serum 25-hydroxy-vitamin D, iPTH, total and ionised calcium, phosphate, and alkaline phosphatase in 129 Swiss children and adolescents with type 1 diabetes.Results: Of the 129 subjects 78 (60.5%) were vitamin D deficient, defined as a 25-hydroxy-vitamin-D level below 50 nmol/L. During the winter this number rose to 84.1%. 25-hydroxy-vitamin-D levels showed marked seasonal fluctuations, whereas there was no correlation with diabetes control. Despite the high prevalence of vitamin D deficiency, we found a low prevalence of secondary hyperparathyroidism in vitamin D deficient diabetic children and adolescents.Conclusions: Prevalence of vitamin D deficiency in diabetic children and adolescents is high. Therefore, screening for vitamin D deficiency and supplementation in children with low vitamin D levels may be considered.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

Janner

Flueck

Mullis

2009

Bone

View full text Add to dashboard Cite

show abstract

“…In our study 25(OH)D was significantly lower (mean ±SD of 7.88 ± 1.20 ng/mL) in patients, compared with 16.64 ± 7.83 ng/mL in the controls. Many recently published studies have found significantly lower levels of 25(OH)D in patients with diabetes compared with controls (6,8,10,26).…”

Section: Discussionmentioning

confidence: 96%

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Daga

Laway

Shah

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

OBJECTIVES: Vitamin D deficiency is common at all ages, and low levels of vitamin D have been associated with high incidence of type 1 diabetes. Similar results are not consistent for type 2 diabetes. The aim of the present study was to estimate vitamin D status in newly detected youth-onset diabetes in north India. SUBJECTS AND METHODS: This was a prospective case control study at a tertiary care hospital in north India. Seventy two newly detected youth-onset diabetes subjects (age < 25 years), and 41 age- and gender-matched healthy controls were studied. In addition to basic information and management regarding their diabetes, metabolic parameters and serum 25(OH)D were measured in both the groups. RESULTS: Vitamin D deficiency was seen in 91.1% of the subjects with diabetes, and 58.5% of the healthy controls. Mean ±SD 25(OH)D was significantly low, 7.88 ± 1.20 ng/mL in subjects with diabetes against 16.64 ± 7.83 ng/mL in controls. Sixty percent of cases had severe Vitamin D deficiency compared with 8.3% in controls. Levels of vitamin D did not correlate with clinical parameters, such as gender, body mass index; or with biochemical parameters, such as serum calcium, phosphorus, alkaline phosphatase, fasting plasma glucose, and HbA1C. CONCLUSION: Vitamin D deficiency is common in people with youth-onset diabetes.

show abstract

“…Overall, 84% of the T1DM children, and 59% of the healthy children were Vitamin D deficient (9). Prevalence of Vitamin D deficiency was 60.5% in a Swiss study (11), 43% in an Australian study (12), approximately 25% in an Italian study (13). In a cross-sectional study performed in Jeddah on 510 child ranged between 4-15 years,13.7% had a normal Vitamin D level,58.8% had relative deficiency,27.4% had severedeficiency.…”

Section: Discussion:-mentioning

confidence: 97%

Prevalence of Vitamin D Deficiency in Type 1 Dm a Control Cross Sectional Study Held in Middle and West Regions of Saudi Arabia.

Sambas¹,

Makeen²,

Yamani³

et al. 2017

IJAR

View full text Add to dashboard Cite

Low Levels of 25-hydroxyvitamin D₃and 1,25-dihydroxyvitamin D₃in Patients with Newly Diagnosed Type 1 Diabetes

Cited by 182 publications

References 9 publications

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Prevalence of Vitamin D Deficiency in Type 1 Dm a Control Cross Sectional Study Held in Middle and West Regions of Saudi Arabia.

Contact Info

Product

Resources

About

Low Levels of 25-hydroxyvitamin D3and 1,25-dihydroxyvitamin D3in Patients with Newly Diagnosed Type 1 Diabetes

Cited by 182 publications

References 9 publications

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Prevalence of Vitamin D Deficiency in Type 1 Dm a Control Cross Sectional Study Held in Middle and West Regions of Saudi Arabia.

Contact Info

Product

Resources

About

Low Levels of 25-hydroxyvitamin D₃and 1,25-dihydroxyvitamin D₃in Patients with Newly Diagnosed Type 1 Diabetes