Low levels of CC16 in nasal fluid of children with birch pollen‐induced rhinitis

Johansson, Sofia; Keen, Christina; Ståhl, Arne; Wennergren, Göran; Benson, Mikael

doi:10.1111/j.1398-9995.2005.00775.x

Cited by 34 publications

(45 citation statements)

References 24 publications

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“…Previous investigations showed a suppressive effect of allergic inflammation on CC16 production [9,11,14]. The levels of CC16 are lower in serum and nasal secretions of allergic children in comparison with healthy ones [14].…”

Section: Discussionmentioning

confidence: 99%

“…We did not investigate the relationship between mucosal production of CC16 and chemokines in patients with intermittent allergic rhinitis because of strong variations in inflammatory mediator levels in nasal secretions of these patients depending the presence of specific seasonal allergens in the air [9,11].…”

Section: Discussionmentioning

confidence: 99%

“…Clara cell protein 16 (CC16), named also "uteroglobin, " is an anti-inflammatory protein of small molecular weight (16 kDa). This mediator is dominantly produced by Clara cells in nasal and bronchoalveolar epithelium [9]. Previous investigations suggest that CC16 has an important role in controlling and inhibition of oxidative stress and inflammatory response in nasal mucosa of patients with seasonal allergic rhinitis (SAR) [10,11].…”

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

“…The anti-inflammatory effect of CC16 is thought to be dependent on the inhibition of pro-inflammatory enzymes phospholipase A2 (PLA2) and transglutaminase. Both these enzymes play a key role in arachidonic acid release during an allergic inflammation [9][10][11]. However, the role of CC16 in regulation of chronic inflammation in patients with PAR has not been fully investigated.…”

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

“…The non-ciliated secretory Clara cells are the part of upper and lower respiratory tract epithelium. These cells have an important function in modulation of immune responses by production of anti-inflammatory factors [9]. Clara cell protein 16 (CC16), named also "uteroglobin, " is an anti-inflammatory protein of small molecular weight (16 kDa).…”

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

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Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

et al. 2017

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Objective: Eotaxin-2 and regulated on activation normal T cell expressed and secreted (RANTES) are involved in the eosinophil trafficking in patients with persistent allergic rhinitis (PAR). Clara cell protein 16 (CC16) is an anti-inflammatory protein mainly produced by the epithelial non-ciliated Clara cells. The aim of this study was to investigate the production of CC16 and chemokines eotaxin-2 and RANTES in nasal mucosa of patients with PAR.Materials and Methods: Twenty-one PAR patients and 20 healthy participants were included. CC16, eotaxin-2, and RANTES concentrations were measured in nasal secretions. PAR patients were administered fluticasone furoate nasal spray (220 μg daily for 14 days). We performed nasal cytology, symptom score assessment, and inflammatory mediator detection before and after the therapy.Results: The level of CC16 in patients with PAR was lower than in the healthy subjects (p=0.023). The eosinophil counts and local concentrations of eotaxin-2 and RANTES were higher in patients with PAR in comparison with controls (p=0.008, p=0.001, p=0.031, respectively). We also found a negative correlation between the CC16 and eotaxin-2 levels in nasal secretions of PAR patients (r=−0.492, p=0.023). After corticosteroid therapy, the patients with PAR had lower nasal symptoms, eosinophil counts, eotaxin-2, and RANTES levels and higher levels of CC16 (p<0.001 for all parameters). Conclusion:Our results suggest the presence of a negative correlation in production of CC16 and eotaxin-2 in nasal mucosa of patients with PAR. Intranasal corticosteroids have a suppressive effect on mucosal eosinophilic inflammation and a stimulating effect on local CC16 production.Keywords: Allergic rhinitis, chemokines, eosinophils, glucocorticoids, inflammation mediators ÖZ Amaç: Eotaksin-2 ve RANTES (aktivasyonla regüle edilen, normal T hücresi ekspresyonu ve sekresyonu) persistan alerjik riniti (PAR) olan hastalarda eozinofil göçünde yer almaktadır. Clara hücresi protein 16 (CC16) çoğunlukla sil içermeyen epitelyal hücreler tarafından üretilirler. Bu çalışmanın amacı PAR hastalarının nazal mukozasında CC16 ve eotaksin-2 ve RANTES kemokinlerinin üretimini araştırmaktır. Gereç ve Yöntemler:Çalışmaya 21 PAR hastası ve 20 sağlıklı katılımcı dahil edildi. Nazal sekresyonlardaki CC16, eotaksin-2 ve RANTES seviyeleri ölçüldü. PAR hastalarına flutikazon furoat nazal sprey uygulandı (14 gün boyunca günlük 220 μg doz). Tedavi öncesi ve sonrasında, nazal sitoloji, semptom skoru değerlendirmesi ve inflamatuar mediyatör taraması yapıldı.Bulgular: CC16 seviyesi PAR hastalarında sağlıklı deneklere kıyasla daha düşük bulundu (p=0,023). Kontrollere göre, eozinofil sayıları ve lokal eotaksin-2 ve RANTES seviyeleri PAR hastalarında daha yüksekti (sırasıyla p=0,008, p=0,001, p=0,031). Ayrıca PAR hastalarının nazal sekresyonlarında CC16 ile eotaksin-2 düzeyleri arasında negatif bir korelasyon bulundu (r=-0,492, p=0,023). Kortikosteroid tedavisi sonrasında, PAR hastalarında daha düşük nazal semptomlar, eozinofil sayıları, eotaksin-...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

See 3 more Smart Citations

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

et al. 2017

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Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

Špadijer-Mirković

Perić

Belic

et al. 2016

Int Forum Allergy Rhinol

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Nasal epithelium biomarkers in young children: Associations with allergic sensitization and environmental stressors

Sardella¹,

Voisin²,

Dumont³

et al. 2012

Pediatric Pulmonology

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Low levels of CC16 in nasal fluid of children with birch pollen‐induced rhinitis

Abstract: Nasal fluid CC16 levels were lower in children with birch pollen-induced allergic rhinitis than in healthy controls both before and during the pollen season. We speculate that reduction in anti-inflammatory activity by CC16 may contribute to the pathogenesis of allergic rhinitis.

Cited by 34 publications

References 24 publications

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

Nasal epithelium biomarkers in young children: Associations with allergic sensitization and environmental stressors

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