Low levels of circulating microRNA-26a/29a as poor prognostic markers in patients with hepatocellular carcinoma who underwent curative treatment

Dissimilar Appearances Are Deceptive–Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma

“…Gao et al found that p53 mediated activation of miR-26a induced apoptosis in HCC cells [175]. Furthermore, low expression of miR-26a correlated with a poor prognosis of HCC patients [144,176]. This finding was also confirmed in patients with HBV-induced HCC [177].…”

Lower expression of tumor microRNA‐26a is associated with higher recurrence in patients with hepatocellular carcinoma undergoing surgical treatment

“…Our study supports the previously described findings by Wang et al that the miR‐26 family provides prognostic information in HCC. A previous study suggested low circulating levels of miR‐26a in a Korean population with HCC was associated with poor liver transplant‐free survival . Multiple Chinese studies have suggested that circulating levels of miR‐26a in combination with other miRNAs can be helpful in differentiating cases of chronic hepatitis B or C and HCC, even at early cancer stages .…”

“…It was previously shown that low tumor levels of miR‐26 in a predominantly HBV‐infected population were associated with shorter overall survival, but better response to interferon therapy in Chinese patients . Additionally, higher miR‐26a levels before curative intervention with radiofrequency ablation or resection have been shown to improve disease‐free survival in South Korean patients . In the United States, Japan, and Europe, HCV infection is more prevalent than HBV and is the major cause of HCC .…”

“…14 Additionally, higher miR-26a levels before curative intervention with radiofrequency ablation or resection have been shown to improve disease-free survival in South Korean patients. 17 In the United States, Japan, and Europe, HCV infection is more prevalent than HBV and is the major cause of HCC. 1 A review from the United States showed that excessive alcohol consumption is also associated with a significant number of HCC cases (32% to 45%) 18 while NAFLD accounts for a growing proportion of cases.…”

“…A previous study suggested low circulating levels of miR-26a in a Korean population with HCC was associated with poor liver transplantfree survival. 17 Multiple Chinese studies have suggested that circulating levels of miR-26a in combination with other miRNAs can be helpful in differentiating cases of chronic hepatitis B or C and HCC, even at early cancer stages. 22,23 Further evaluation of circulating miR-26a as a tool to predict HCC recurrence and survival may be warranted.…”