Low Levels of Low-Density Lipoprotein Cholesterol and Blood Pressure and Progression of Coronary Atherosclerosis

Abstract

Very low LDL-C and normal SBP are associated with the slowest progression of coronary atherosclerosis. Although a greater beneficial association is observed in patients with very low LDL-C, these findings suggest the need for intensive control of global risk in patients with CAD.

Plaque Regression Determined by Intravascular Ultrasound Predicts Long-Term Outcomes of Patients with Acute Coronary Syndrome

“…We similarly postulate that blood pressure plays an important role in the promotion of coronary artery disease. Chhatriwalla et al found the most attenuation of coronary plaque progression in patients with very low LDL-C ( ≤ 70 mg/dL) together with normal systolic blood pressure ( ≤ 120 mmHg) 24) . The results of another large pooled analysis also found that despite achieving intensive control of LDL-C, plaque continued to progress in 20% of patients with coronary artery disease 25) .…”

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

“…Традиционные факторы риска развития ИБС [31][32][33] -артериальная гипертония [34], гиперхолестери-немия [35], сахарный диабет [36], малоподвижный образ жизни [37], ожирение [37], курение [34,38] и отягощенный семейный анамнез [39] -неблаго-приятно влияют на прогноз у лиц с установленным заболеванием, главным образом посредством своего влияния на прогрессирование процессов атероскле-ротического заболевания. Тем не менее, адекватное лечение способно снизить эти риски [40][41][42].…”

Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease

“…Conventional risk factors of CAD [23][24][25], hypertension [25], hypercholesterolemia [26], diabetes, [27] obesity, [28] smoking, [25,29] and family history…”