Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study

Abstract

In the present study, we investigated various biochemical, clinical, and histological factors associated with bone metastases in a large cohort of pre- and postmenopausal women with breast cancer. Two hundred and sixty-one consecutive women with breast cancer were included in this study. Breast adipose tissue specimens were collected during surgery. After having established the fatty acid profile of breast adipose tissue by gas chromatography, we determined whether there were differences associated with the occurrence of bone metastases in these patients. Regarding the clinical and histological criteria, a majority of the patients with bone metastases (around 70%) had tumors with a luminal phenotype and 59% of them showed axillary lymph node involvement. Moreover, we found a negative association between the levels of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in breast adipose tissue and the development of bone metastases in premenopausal women. No significant association was observed in postmenopausal women. In addition to a luminal phenotype and axillary lymph node involvement, low levels of n-3 LC-PUFA in breast adipose tissue may constitute a risk factor that contributes to breast cancer bone metastases formation in premenopausal women.

The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

“…In recent years, preclinical [ 17 , 18 , 19 ] and clinical studies [ 20 , 21 ] have shown that omega-3 polyunsaturated fatty acids (ω-3 PUFA) represent an efficient, supportive therapeutic approach for the treatment of breast cancer [ 22 ]. They are considered essential dietary nutrients considering that they cannot be produced naturally through biochemical and metabolic processes.…”

Cyclotrisiloxan and β-Sitosterol rich Cassia alata (L.) flower inhibit HT-115 human colon cancer cell growth via mitochondrial dependent apoptotic stimulation

“… Peak No. List of compounds Peak area (%) Retention time Reported Anticancer activity 1 2-Pentanol 3.28 4.321 – 2 4-methyl-3-pentanol 6.90 6.37 – 3 2-nonanone 0.12 9.78 – 4 Hexadecanoic acid 4.05 22.89 – 5 9,12-Octadecanoic acid 1.82 6.76 24.54 25.19 ( Goupille et al, 2020 ) 6 9,12,15- Octadecatrienoic acid 3.11 24.59 ( Zhang et al, 2020 ) 7 Cyclotrisiloxane 0.12 0.67 0.49 0.43 0.89 1.08 1.01 28.68 30.28 30.64 30.73 31.06 31.51 34.32 ( Bouabdallah et al, 2016 ) 8 Eicosane 3.38 2.98 29.43 30.826 ( Ignatenko et al, 2006 ) 9 13-Decosenamide 8.16 30.096 – 10 Cyclohexane 2.55 32.36 – 11 Alpha-tocopherol 1.94 32.78 ( Jiang, 2019 ) 12 Campesterol 3.19 33.85 ( Alvarez-Sala et al, 2019 ) 13 Stigmasterol 7.85 34.21 ( Alvarez-Sala et al, 2019 ) ...…”

DHA inhibits invasion and metastasis in NSCLC cells by interfering with CCL18/STAT3 signaling pathway

“…In the present study, we found that the two major omega-3 EPA and DHA at 60 µM had no obvious effect on the growth and proliferation of NSCLC cells, but effectively inhibited the migration and invasion of lung cancer cells, whereby the inhibitory effect of DHA was more pronounced that of EPA. Recently, Goupille et al [ 24 ] reported that the levels of omega-3 in breast adipose tissue were negatively correlated with the development of bone metastases in premenopausal women with breast cancer. Pfister et al [ 25 ] found that omega-3 suppresses the invasion in colorectal cancer cells by a PI3K-dependent mechanism but had no effect on cell proliferation.…”