Low levels of selenium in miscarriage

Güvenç, Müzehher; Güven, Hüseyin; Karataş, Fikret; Aygün, A. Denizmen; Bektaş, Sırrı

doi:10.1002/jtra.10004

Cited by 10 publications

(4 citation statements)

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“…Another limitation of this study is that essential metals such as iron, selenium, zinc, magnesium, and calcium, were not measured. These metals may interfere with reproduction in women [ 2 , 66 , 67 ]. More than 80 % of the infertile women in our study came from urban areas.…”

Section: Discussionmentioning

confidence: 99%

Relationship between risk factors for infertility in women and lead, cadmium, and arsenic blood levels: a cross-sectional study from Taiwan

Lei

Wei

et al. 2015

BMC Public Health

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BackgroundThe World Health Organization reported that more than 10 % of women are severely affected by infertility, making the condition a major worldwide public health problem. Lead (Pb), cadmium (Cd), and arsenic (As) are environmental pollutants that may contribute to reproductive disorders. This cross-sectional study investigated the association between blood concentrations of Pb, Cd, and As and risk factors for infertility in women.MethodsWomen who were infertile (N = 310) or pregnant (N = 57) were recruited from the gynecology and obstetrics department of a hospital. The participants were interviewed to obtain their sociodemographic, reproductive, and lifestyle information. The concentrations of Pb, Cd, and As in their blood samples were measured using inductively coupled plasma mass spectrometry.ResultsOur findings suggested that the concentrations of Pb and As, but not Cd, were significantly higher in the blood of infertile women than in that of pregnant women. A higher percentage of the infertile women consumed more alcohol, used Chinese herbal medicine more frequently, and lacked physical activity compared with the pregnant women. After accounting for potentially relevant predictors, we observed that blood Pb levels might be elevated by using Chinese herbal medicine 1–6 times per week (aOR = 2.82, p = 0.05). In addition, engaging in physical activity 1–2 times per week (aOR = 0.37, p = 0.05) might assist in reducing Pb accumulation in infertile women, though the p value was borderline.ConclusionsLack of physical activity and frequent use of Chinese herbal medicine may be associated with elevated blood Pb levels in infertile women. Chinese herbal medicine use was observed to increase the Pb body burden of both infertile and pregnant women in this study. The risk–benefit for Chinese herbal medicine intake should be evaluated by women of childbearing age.

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Section: Discussionmentioning

confidence: 99%

Relationship between risk factors for infertility in women and lead, cadmium, and arsenic blood levels: a cross-sectional study from Taiwan

Lei

Wei

et al. 2015

BMC Public Health

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“…The increased fertility following the addition of Se is ascribed to the decrease in embryonic death during the first thirty days of pregnancy [55]. Most female based studies are mainly centered on the role of Se in pregnancy [56,57,58,59,60]; only recently has some light been shed on its potential role in oocyte development and ovarian physiology [8,53,61].…”

Section: Introductionmentioning

confidence: 99%

Selenium, Selenoproteins, and Female Reproduction: A Review

et al. 2018

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Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are reportedly present in all three domains of life. As a component of selenoproteins, Se has structural and enzymatic functions; in the latter context it is best recognized for its catalytic and antioxidant activities. In this review, we highlight the biological functions of Se and selenoproteins followed by an elaborated review of the relationship between Se and female reproductive function. Data pertaining to Se status and female fertility and reproduction are sparse, with most such studies focusing on the role of Se in pregnancy. Only recently has some light been shed on its potential role in ovarian physiology. The exact underlying molecular and biochemical mechanisms through which Se or selenoproteins modulate female reproduction are largely unknown; their role in human pregnancy and related complications is not yet sufficiently understood. Properly powered, randomized, controlled trials (intervention vs. control) in populations of relatively low Se status will be essential to clarify their role. In the meantime, studies elucidating the potential effect of Se supplementation and selenoproteins (i.e., GPX1, SELENOP, and SELENOS) in ovarian function and overall female reproductive efficiency would be of great value.

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“…Essential metals in infertility women should not be limiting factors to affect the results of infertility risk. Another limitation of our work was that the associations of relevant factors and related metals (Pb, Hg, As, Cd, Cr, and Cu) were not yet accessed, which may also exert a wide variety of adverse effects on reproduction (Güvenç et al, 2002;Satarug and Moore, 2004;Anderson et al, 2010;Apostoli and Catalani, 2011). Additional research is highly needed to further elucidate the effects and influencing mechanisms of these metals on hormone and the relevant factors for infertile women.…”

Section: Discussionmentioning

confidence: 82%