Low levels of serum serotonin and amino acids identified in migraine patients

Ren, Caixia; Liu, Jia; Zhou, Juntuo; Liang, Hui; Wang, Yayun; Sun, Yan; Ma, Baochun; Yin, Yuxin

doi:10.1016/j.bbrc.2017.11.203

Cited by 44 publications

(37 citation statements)

References 27 publications

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“…For comparison group f, ictal vs interictal also refers to the active cluster bout vs remission. In addition to the references from Table 3 with clear blood specimen descriptions (n = 30), 15 references were included 21,26,27,37,39,43,48,125‐132 . Abbreviations: chronic cluster headache (CCH); chronic migraine (CM); control (CTRL); episodic cluster headache (ECH); female/female‐dominated (F/FD); migraine (M); both sexes (M/F); male/male‐dominated (M/MD); migraine with aura (MWA); migraine without aura (MWoA).…”

Section: Resultsmentioning

confidence: 99%

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Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case‐Control and Case‐Crossover Settings: A Systematic Review and Meta‐Analysis

Frederiksen¹,

Dunbar

Snoer

et al. 2020

Headache

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Objective.-The aim of this systematic review and meta-analysis (SR-MA) was to identify signaling molecule profiles and blood-derived biomarkers in migraine and cluster headache (CH) patients.Background.-Currently no migraine and CH valid biomarkers are available. Blood tests based on biomarker profiles have been used to gather information about the nervous system. Such tests have not yet been established within the primary headache field.Methods.-Case-control and case-crossover studies investigating whole blood, plasma, and serum were identified worldwide. The qualitative synthesis focused on 9 signaling molecules (serotonin [5-HT], calcitonin gene-related peptide [CGRP], endothelin-1 [ET-1], neurokinin A, neurokinin B, neuropeptide Y, pituitary adenylate cyclase-activating peptide 38 [PACAP-38], substance P (SP), and vasoactive intestinal peptide) and the quantitative synthesis on 5-HT and CGRP (≥5 comparisons available). The meta-analysis was conducted using standard and 3-level random effect models.Results.-Fifty-four eligible studies were identified (87.0% migraine, 9.3% CH, 3.7% migraine, and CH), and 2768 headache patients and 1165 controls included. Comparable fluctuations of 5-HT, CGRP, ET-1, PACAP-38, and SP in blood were generally observed between migraine and CH. Significant findings were observed for some subgroups and strata, for example, higher interictal and ictal 5-HT venous blood levels (ratio of means = 1.32, 95% CI: 1.08; 1.61; ratio of means = 1.23, 95% CI: 1.01; 1.49) in episodic migraine with aura with a female-dominated case group, higher interictal CGRP blood levels in episodic migraine (ratio of means = 1.63, 95% CI: 1.18; 2.26), and chronic migraine (ratio of means = 1.89, 95% CI: 1.33; 2.68), and higher ictal CGRP blood levels (ratio of means = 1.35, 95% CI: 1.09; 1.68) in episodic migraine were observed. In most subgroups, the quantitative synthesis revealed a high degree of heterogeneity between studies in part explained by the blood sampling site, specimen source, blood specimen, and sex distribution. Other potential confounders were age, aura, study quality, menstrual cycle, and methodology (eg, storage temperature).Conclusions.-Potential migraine and CH signaling molecule profiles and biomarkers were revealed. Nevertheless, the high degree of heterogeneity between studies impedes identification of valid biomarkers but allowed us to assess the presence of confounders. Consideration of the potential confounders identified in this SR-MA might be of importance in the experimental planning of future studies. This consideration could be incorporated through establishment of specific guidelines. Abbreviations: 2SD 2 times standard deviation, 5-HIAA 5-hydroxyindoleacetic acid, 5-HT serotonin, 5-HT 1B/1D serotonin receptor 1B/1D, CC, column chromatography, CC-RIA column chromatography and radioimmunoassay, CGRP calcitonin gene-related peptide, CH cluster headache, CI confidence interval, CSF cerebrospinal fluid, CTRL controls, CV coefficient of variation, D Cook's distance, EIA enzyme immun...

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Section: Resultsmentioning

confidence: 99%

“…(A) Meta‐analysis of 5‐HT in episodic migraine (cases) compared with controls (CTRL). Ren et al 130 was excluded due to missing essential measures. Meta‐analysis of chronic migraine (cases) compared with CTRL were not conducted due to only one eligible study identified.…”

Section: Resultsmentioning

confidence: 99%

Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case‐Control and Case‐Crossover Settings: A Systematic Review and Meta‐Analysis

Frederiksen¹,

Dunbar

Snoer

et al. 2020

Headache

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“…Hyper-levels of nNOS are typically noted during nerve injury, which further activate ion channels and protein kinase to exhibit modulatory effects on pain. 5-HT, involved in the pathophysiology of migraines, is suppressed in patients with headaches (Ren et al, 2018). A previous study also supported the use of 5-HT to regulate inflammation-induced pain (Kim et al, 2015).…”

Section: Discussionmentioning

confidence: 64%

Analgesic effects of astilbin partially via calcium channels through regulation on CaMKII

Sun

Chu

et al. 2019

Food and Agricultural Immunology

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This study aimed to evaluate the analgesic efficacy of astilbin and its underlying mechanisms. Astilbin suppressed the symptoms of acetic acid-induced writhing, lengthened the latency period on the hot plate, and reduced the licking and biting response of formalin-injected mice, suggesting its analgesic efficacy on the central nervous system. Astilbin suppressed neuronal nitric oxide synthase and enhanced serotonin and norepinephrine in serum and brains of mice after 30 s of thermal stimulation, but it failed to influence their levels before thermal stimulation. Among six chosen antagonists, only nimodipine, a calcium channel blocker, strongly enhanced the abirritation of astilbin, as indicated by the lengthened latency period of mice treated with nimodipine plus astilbin in the hot plate test. The expression levels of c-Fos and phosphorylated calmodulin-dependent protein kinase II and c-Jun N-terminal kinase in the brains were reduced in the astilbintreated mice. Astilbin-mediated analgesia is partially related to Ca 2+ channels. ARTICLE HISTORY

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“…More recently, several lines of evidence are converging to imply that the physiological mechanisms of migraine may influence diet. [66][67][68] Levels of hypothalamic neurotransmitters, hormones, and adipocytokines have been found to differ in migraine patients as compared to controls in such a way that may impact hunger/feeding or metabolic control: orexin A was higher during the pain phase of chronic migraine, 139 serotonin levels were decreased interictally, 140,141 insulin resistance is detected in higher levels in migraine disease, 142 as well as increased adipocytokines like leptin. [136][137][138] Second, activation of the hypothalamus, the brain's hunger and feeding center, is observed during the premonitory phase of migraine and coincides with the timing of food cravings.…”

Section: Future Directions Of Dietary Migraine Researchmentioning

confidence: 99%

“…[136][137][138] Second, activation of the hypothalamus, the brain's hunger and feeding center, is observed during the premonitory phase of migraine and coincides with the timing of food cravings. [66][67][68] Levels of hypothalamic neurotransmitters, hormones, and adipocytokines have been found to differ in migraine patients as compared to controls in such a way that may impact hunger/feeding or metabolic control: orexin A was higher during the pain phase of chronic migraine, 139 serotonin levels were decreased interictally, 140,141 insulin resistance is detected in higher levels in migraine disease, 142 as well as increased adipocytokines like leptin. 143 Anecdotally, the overall symptoms of migraine (pain and other feelings of unwell) are likely to influence food choices, such that individuals will likely choose convenience and ease, which do not favor a nutritious profile in much of the modern world.…”

Section: Future Directions Of Dietary Migraine Researchmentioning

confidence: 99%

What is Needed for Evidence‐Based Dietary Recommendations for Migraine: A Call to Action for Nutrition and Microbiome Research

Slavin

Frankenfeld

2019

Headache

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Background.-The gastrointestinal symptoms of migraine attacks have invited numerous dietary hypotheses for migraine etiology through the centuries. Substantial efforts have been dedicated to identifying dietary interventions for migraine attack prevention, with limited success. Meanwhile, mounting evidence suggests that the reverse relationship may also exist -that the biological mechanisms of migraine may influence dietary intake. More likely, the truth involves some combination of both, where the disease influences food intake, and the foods eaten impact the manifestations of the disease. In addition, the gut's microbiota is increasingly suspected to influence the migraine brain via the gut-brain axis, though these hypotheses remain largely unsubstantiated.Objective.-This paper presents an overview of the strength of existing evidence for food-based dietary interventions for migraine, noting that there is frequently evidence to suggest that a dietary risk factor for migraine exists but no evidence for how to best intervene; in fact, our intuitive assumptions on interventions are being challenged with new evidence. We then look to the future for promising avenues of research, notably the gut microbiome.Conclusion.-The evidence supports a call to action for high-quality dietary and microbiome research in migraine, both to substantiate hypothesized relationships and build the evidence base regarding nutrition's potential impact on migraine attack prevention and treatment.

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Low levels of serum serotonin and amino acids identified in migraine patients

Cited by 44 publications

References 27 publications

Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case‐Control and Case‐Crossover Settings: A Systematic Review and Meta‐Analysis

Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case‐Control and Case‐Crossover Settings: A Systematic Review and Meta‐Analysis

Analgesic effects of astilbin partially via calcium channels through regulation on CaMKII

What is Needed for Evidence‐Based Dietary Recommendations for Migraine: A Call to Action for Nutrition and Microbiome Research

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