Low levels of soluble low-density lipoprotein receptor-related protein 1 in patients with type 2 diabetes mellitus and diabetic retinopathy

Oto, Bilge Batu; Aykut, Veysel; Gunes, Medine; Korkmaz, Rabia; İşman, Ferruh Kemal; Ağırbaşlı, Mehmet

doi:10.1016/j.exer.2022.108921

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Similarly, the biological and clinical effects of LRP1 or sLRP1 levels in chronic and complex diseases remain to be elucidated. A prior clinical study reported that lower sLRP1 levels are observed in diabetic patients with retinopathy compared to healthy controls [ 21 ]. Other studies indicated that sLRP1 is associated with the presence of epicardial fat, hyperlipidemia, or atherosclerosis [ 16 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of Low Levels of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 and COVID-19 Outcomes During the First Wave of Pandemic

Ağırbaşlı¹,

Korkmaz²,

İşman³

2023

Cureus

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Low-density lipoprotein receptor-related protein-1 (LRP1) is an endocytosis receptor that clears inflammatory proteins from circulation. LRP1 has anti-inflammatory effects that bind pro-inflammatory cytokines or ligands. LRP1 has a soluble form (sLRP1) which can be measured in serum. We report sLRP1 levels in hospitalized patients with COVID-19. The first objective of this study is to compare the sLRP1 levels between COVID-19 patients and healthy controls. The second objective is to examine the association between sLRP1 and the clinical outcome of COVID-19.All patients (20-80 years of age) were evaluated in a hospital using a positive PCR test for SARS-CoV-2 between April 1, 2020, and June 1, 2020. Controls (n=59) were selected from healthy subjects. sLRP1 levels were measured in patients from the emergency department (ED), inpatient service (IS), and the intensive care unit (ICU). The study included 180 cases. COVID-19 patients showed significantly lower sLRP1 levels compared to controls (1.43 (1.86) versus 2.27 (1.68) μg/mL, respectively, p<0.001). sLRP1 levels were 1.26 (1.81), 1.37 (1.65), and 1.74 (1.98) μg/mL in patients from ED, IS, and ICU, respectively (p=0.022). Patients who were admitted from ED displayed lower sLRP1 levels compared to those who were discharged (median sLRP1 levels were 0.86 versus 1.7 μg/mL, p=0.045).COVID-19 patients display significantly lower sLRP1 levels compared to the healthy controls. sLRP1 levels do not show any association with the clinical outcome of COVID-19. This study demonstrates that LRP1 displays a bidirectional course in COVID-19. A low sLRP1 level is a potential risk factor for susceptibility and hospital admission due to COVID-19. Further studies with larger sample sizes and longer follow-ups are needed to understand the long-term effects of novel biomarkers such as sLRP1 on the outcome of COVID-19.

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Section: Discussionmentioning

confidence: 99%

“…Other studies indicated that sLRP1 is associated with the presence of epicardial fat, hyperlipidemia, or atherosclerosis [ 16 , 22 ]. The effects of LRP1 on chronic complex diseases do not appear to be through altering levels and function of serum lipoproteins [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Low Levels of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 and COVID-19 Outcomes During the First Wave of Pandemic

Ağırbaşlı¹,

Korkmaz²,

İşman³

2023

Cureus

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“…Remnant cholesterol (RC) is an emerging tool representing cholesterol in triglyceride-rich lipoproteins and is implicated in a spectrum of conditions, encompassing cardiovascular and metabolic disorders [ 9 ]. Serum lipids have emerged as potential biomarkers for various diseases, including cardiovascular and cerebrovascular diseases [ 10 , 11 ], metabolic diseases [ 12 ], infectious diseases [ 13 ], hematological diseases [ 14 ], and cancer [ 15 ]. Most previous studies on cholesterol metabolism focused on low-density lipoprotein cholesterol (LDL-C) and HDL-C. RC was recently demonstrated to equally precisely predict atherosclerotic cardiovascular disease (CVD) risk compared to LDL-C or very low-density lipoprotein (VLDL) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study

Yan,

La,

Jiang

et al. 2024

Lipids Health Dis

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Objectives While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC is associated with RA disease events. Methods Data were collected and specifically extracted from the National Health and Nutrition Examination Survey (NHANES) 1999–2008 database. The RC value was derived by subtracting the combined amount of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) from the total cholesterol (TC). The association between RC and RA was evaluated using multivariate regression analysis and subgroup analysis. Results The study analyzed 7777 patients, of which 581 patients (7.47%) were diagnosed with RA. After accounting for different covariates, the multivariate logistic regression analysis revealed a notable correlation between increased RC levels and an increased likelihood of RA (odds ratio OR = 1.54; 95% confidence interval CI: 1.11–2.13; P = 0.0092). The interaction test did not yield statistically significant effects on this association. The linear correlation between RC and RA was observed within restricted cubic spline regression model limitations. Conclusion The results suggest that higher RC levels are associated with increased odds of RA, indicating that RC can serve as a novel and convenient index for forecasting the likelihood of RA in the United States. Additionally, these findings offer insights into early intervention strategies for susceptible populations at risk of developing RA.

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Soluble low density lipoprotein receptor-related protein-1 levels in the differential diagnosis of myopericarditis versus acute coronary syndrome

Ağırbaşlı

Bölen

Konal

et al. 2022

The American Journal of Emergency Medicine

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Low levels of soluble low-density lipoprotein receptor-related protein 1 in patients with type 2 diabetes mellitus and diabetic retinopathy

Cited by 4 publications

References 30 publications

Association of Low Levels of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 and COVID-19 Outcomes During the First Wave of Pandemic

Association of Low Levels of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 and COVID-19 Outcomes During the First Wave of Pandemic

The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study

Soluble low density lipoprotein receptor-related protein-1 levels in the differential diagnosis of myopericarditis versus acute coronary syndrome

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