Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study 9 (TOPICS 9)

Heianza, Yoriko; Arase, Yasuji; Tsuji, Hiroshi; Saito, Kazumi; Amakawa, Kazuhisa; Hsieh, Shiun Dong; Kodama, Satoru; Shimano, Hitoshi; Yamada, Nobuhiro; Sone, Hirohito

doi:10.1016/j.mayocp.2012.04.016

Cited by 31 publications

(37 citation statements)

References 36 publications

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“…Over a follow-up period of 20.9 years, the Normative Aging Study found that FVC, FEV 1 and maximal midexpiratory flow rate (MMEF) were associated with insulin resistance [56]. Likewise, 6 other studies, which included follow-ups of 4-13.9 years, observed that impaired lung function is a predictor of diabetes [57,58,59,60,61,62]. Nevertheless, although an association between reduced pulmonary function and the incidence of diabetes was observed by analysis of data from the National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study, a link between COPD and diabetes could not be confirmed [63].…”

Section: The Impact Of Copd On Patients With Diabetesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A Systematic Review of the Literature

et al. 2015

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The objective of this systematic review was to discuss our current understanding of the complex relationship between chronic obstructive pulmonary disease (COPD) and type-2 diabetes mellitus (T2DM). We performed a systematic search of the literature related to both COPD and diabetes using PubMed. Relevant data connecting both diseases were compiled and discussed. Recent evidence suggests that diabetes can worsen the progression and prognosis of COPD; this may result from the direct effects of hyperglycemia on lung physiology, inflammation or susceptibility to bacterial infection. Conversely, it has also been suggested that COPD increases the risk of developing T2DM as a consequence of inflammatory processes and/or therapeutic side effects related to the use of high-dose corticosteroids. In conclusion, although there is evidence to support a connection between COPD and diabetes, additional research is needed to better understand these relationships and their possible implications.

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Section: The Impact Of Copd On Patients With Diabetesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A Systematic Review of the Literature

et al. 2015

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“…[1][2][3][4][5][6][7][8][9] A representative obstructive lung disease, chronic obstructive pulmonary disease (COPD), is now well known to be associated with a variety of comorbidities, including DM. [10][11][12][13] However, an accelerated decline of lung function has been observed in patients with DM.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional and prospective study of the association between lung function and prediabetes

et al. 2013

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ObjectivesA growing body of evidence suggests that there is a relationship between impaired lung function and the risk of developing diabetes mellitus (DM). However, it is not known if this reflects a causal effect of lung function on glucose metabolism. To clarify the relationship between lung function and the development of DM, we examined the incidence of newly diagnosed prediabetes (a precursor of DM) among subjects with normal glucose tolerance (NGT) at baseline.DesignPrimary analysis of an occupational cohort with both cross-sectional and longitudinal data (follow-up duration mean±SD: 28.4±6.1 months).Setting and participantsData were analysed from 1058 men in a cross-sectional study and from 560 men with NGT in a longitudinal study.Outcomes and methodsImpaired lung function (per cent predicted value of forced vital capacity (%FVC) or per cent value of forced expiratory volume 1 s/FVC (FEV1/FVC ratio)) in relation to the ratio of prediabetes or DM in a cross-sectional study and development of new prediabetes in a longitudinal study. NGT, prediabetes including impaired glucose tolerance (IGT) and increased fasting glucose (IFG) and DM were diagnosed according to 75 g oral glucose tolerance tests.Measurements and main results%FVC at baseline, but not FEV1/FVC ratio at baseline, was significantly associated with the incidences of DM and prediabetes. Among prediabetes, IGT but not IFG was associated with %FVC. During follow-up, 102 subjects developed prediabetes among those with NGT. A low %FVC, but not FEV1/FVC ratio, was predictive of an increased risk for development of IGT, but not of IFG.ConclusionsLow lung volume is associated with an increased risk for the development of prediabetes, especially IGT, in Japanese men. Although there is published evidence for an association between chronic obstructive pulmonary disease and DM, prediabetes is not associated with the early stage of COPD.

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“…Moreover, only 19 in women developed diabetes; therefore, the statistical power was insufficient to demonstrate a significant association between the tertiles of %VC and incident diabetes in women. The present study may also lack sufficient statistical power to demonstrate a significant association between the vital capacity and incident diabetes in men, as previous studies demonstrated significant associations between a decreased vital capacity and incident diabetes in Korean (13) and Japanese (14) men.…”

Section: Limitationsmentioning

confidence: 75%

“…Kwon et al reported that a reduced lung function was found to be significantly associated with incident diabetes after adjusting for age, BMI, education, smoking, exercise, alcohol and homeostasis model assessment of insulin resistance in Korean men in a five-year follow-up study (13). Meanwhile, Heianza et al reported that a relatively low FEV1 was an independent risk factor for diabetes among apparently healthy Japanese men in a four-year follow-up study (14).…”

Section: Discussionmentioning

confidence: 99%

“…A decreased vital capacity has been reported to be a new predictor of diabetes in Western countries where the prevalence of obesity is high (4)(5)(6)(7)(8)(9)(10). Meanwhile, there have been few reports (11)(12)(13)(14) regarding the relationship between the lung function and diabetes in East Asian populations where the prevalence of obesity is low and there have been no studies regarding the relationship between the respiratory function and incident diabetes in East Asian women. The vital capacity is inversely correlated with the level of high-sensitivity Creactive protein (hs-CRP), a marker of chronic subclinical systemic inflammation and a generally accepted risk factor for diabetes (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Low Vital Capacity was Found to be Associated with Incident Diabetes in Health Screening Population of Japanese Women

Oda

2014

Intern. Med.

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Objective There have been no previous studies regarding the relationship between the respiratory function and incident diabetes in East Asian women in whom obesity is not prevalent. Methods Using Cox regression models, hazard ratios (HRs) for incident diabetes for each one SD increase in the percent vital capacity (%VC), a parameter of restrictive pulmonary dysfunction, forced expiratory volume in one second over forced vital capacity (FEV1/FVC), a parameter of obstructive pulmonary dysfunction, and log high-sensitivity C-reactive protein (hs-CRP) were calculated in 1,704 men and 1,016 women among a Japanese health screening population. Results Over the four-year study period (mean of 3.4 years), 54 men (3.2%) and 19 women (1.9%) developed diabetes. The HRs [95% confidence intervals (CIs); p values] for incident diabetes for each one SD increase in %VC and log hs-CRP were 0.81 (0.61-1.06; 0.127) and 1.29 (0.97-1.73; 0.085), respectively in men, and 0.55 (0.35-0.88) 0.012 and 2.50 (1.37-4.57; 0.003), respectively in women adjusted for age, fasting glucose and body mass index. The FEV1/FVC was not found to be significantly associated with incident diabetes in any regression models. The Spearman's correlation coefficients between %VC and hs-CRP was -0.11 (p<0.001) in men and -0.08 (p=0.007) in women. The HRs (95% CIs; p values) for each one SD increase in %VC and hs-CRP were 0.86 (0.65-1.13; 0.278) and 1.26 (0.94-1.70; 0.125), respectively in men, and 0.56 (0.34-0.94; 0.028) and 2.95 (1.49-5.81; 0.002), respectively in women, further adjusted for each other, systolic blood pressure, triglycerides and HDL cholesterol. Conclusion A low %VC was found to be associated with incident diabetes, independent of hs-CRP in women among a Japanese health screening population.

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Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study 9 (TOPICS 9)

Cited by 31 publications

References 36 publications

Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A Systematic Review of the Literature

Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A Systematic Review of the Literature

Cross-sectional and prospective study of the association between lung function and prediabetes

Low Vital Capacity was Found to be Associated with Incident Diabetes in Health Screening Population of Japanese Women

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