Low maternal vitamin D status in pregnancy increases the risk of childhood obesity

Daraki, Vasiliki; Roumeliotaki, Theano; Chalkiadaki, Georgia; Katrinaki, Marianna; Karachaliou, Marianna; Leventakou, Vasiliki; Vafeiadi, Marina; Sarri, Katerina; Vassilaki, Maria; Papavasiliou, Stathis; Kogevinas, Manolis; Chatzi, Lida

doi:10.1111/ijpo.12267

Cited by 39 publications

(46 citation statements)

References 29 publications

(42 reference statements)

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“…A growing body of evidence suggests that maternal vitamin D status in pregnancy may play a part in the offspring adipogenesis [185][186][187][188][189]; however, not all studies are in agreement [190,191]. Tint et al conducted a study to examine the association between maternal 25(OH)D status at mid-gestation and neonatal abdominal adipose tissue (AT) compartments.…”

Section: Offspring Soft Tissue Body Compositionmentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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Maternal vitamin D deficiency in pregnancy is a widespread public health concern. Race and ethnicity as biological and cultural factors, respectively, can affect vitamin D status through differences in skin color, sunlight exposure, and dietary intake. Low maternal vitamin D status in pregnancy may affect both mother and fetus adversely. Vitamin D deficiency and insufficiency are linked to a wide variety of adverse pregnancy outcomes such as gestational diabetes, preeclampsia, and preterm delivery. Furthermore, maternal vitamin D deficiency has been linked to several adverse health outcomes in infants and children. The examples include, but not limited to, impaired growth, skeletal problems, and autoimmune diseases such as type 1 diabetes and asthma. This chapter reviews the vitamin D status during pregnancy across different ethnic groups, looking into the adverse pregnancy and child outcomes, followed by a discussion on the association between maternal and child vitamin D status and successful interventions. Strong evidence exists about the association between vitamin D and some health outcomes during pregnancy, while more studies are needed to confirm the other claim. The existing body of evidence justifies the need for well-designed policies and systematic interventions to ensure optimal vitamin D status of pregnant women and their offsprings across different ethnic and racial groups.

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Section: Offspring Soft Tissue Body Compositionmentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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“…For example, rodent studies have demonstrated that maternal vitamin D deficiency leads to adult onset cardiovascular dysfunction that is associated with elevated blood pressure, perturbed heart rate and cardiac hypertrophy . Vitamin D deficiency during pregnancy is also associated with increased adiposity in childhood . Maternal vitamin B deficiencies have been linked to epigenetic alterations and DNA methylation, associated with overweight offspring, an impaired immune response, hypertension and metabolic insulin resistance …”

Section: Long Term Effects Of Micronutrient Deficiencies On Offspringmentioning

confidence: 99%

“…26 Vitamin D deficiency during pregnancy is also associated with increased adiposity in childhood. 27 Maternal vitamin B deficiencies have been linked to epigenetic alterations and DNA methylation, associated with overweight offspring, an impaired immune response, hypertension and metabolic insulin resistance. 28 Through models such as these, it has become evident that key organ systems are central to long term disease.…”

Section: Magnesium Deficiency Hasmentioning

confidence: 99%

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

Hofstee

McKeating

Perkins

et al. 2018

Clin Exp Pharma Physio

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Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation. In contrast, animal studies have demonstrated how diets high or low in specific micronutrients influence offspring physiology. Many of these studies highlight the importance of the placenta in determining disease risk. This review will explore the effects of individual vitamins, minerals and trace elements on offspring disease outcomes and discuss several key placental adaptations that are affected by multiple micronutrients. These placental adaptations include micronutrient induced dysregulation of oxidative stress, altered methyl donor availability and its impact on epigenetic mechanisms as well as endocrine dysfunction. Critical gaps in our current knowledge and the relative importance of different micronutrients at different gestational ages will also be highlighted. Finally, this review will discuss the need for further studies to characterise the micronutrient status of Australian women of reproductive age and correlate micronutrient status to placental adaptations, pregnancy complications and offspring disease.

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“…The measurements were conducted at Karolinska Institutet, Sweden, using inductively coupled plasma mass spectrometry (ICPMS; Agilent 7700x, Agilent Technologies, Tokyo, Japan) (21). The urine samples were diluted 1:10 in 1% nitric acid (prepared from 65% suprapur, Merck, Darmstadt, Germany (23,24). These internally generated SD scores were preferred for this study over external growth reference curves (e.g.…”

Section: Sample Collection and Trace Element Analysesmentioning

confidence: 99%

Associations of Prenatal Exposure to Cadmium With Child Growth, Obesity, and Cardiometabolic Traits

Chatzi

Ierodiakonou

Margetaki

et al. 2018

American Journal of Epidemiology

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Abstract Prenatal cadmium exposure has been associated with impaired fetal growth; much less is known about the impact during later childhood on growth and cardiometabolic traits. To elucidate the associations of prenatal cadmium exposure with child growth, adiposity, and cardiometabolic traits in 515 mother-child pairs in the Rhea Mother-Child Study cohort (Heraklion, Greece, 2007–2012), we measured urinary cadmium concentrations during early pregnancy and assessed their associations with repeated weight and height measurements (taken from birth through childhood), waist circumference, skinfold thickness, blood pressure, and serum lipid, leptin, and C-reactive protein levels at age 4 years. Adjusted linear, Poisson, and mixed-effects regression models were used, with interaction terms for child sex and maternal smoking added. Elevated prenatal cadmium levels (third tertile of urinary cadmium concentration (0.571–2.658 μg/L) vs. first (0.058–0.314 μg/L) and second (0.315–0.570 μg/L) tertiles combined) were significantly associated with a slower weight trajectory (per standard deviation score) in all children (β = −0.17, 95% confidence interval (CI): −0.32, −0.02) and a slower height trajectory in girls (β = −0.30, 95% CI: −0.52,−0.09; P for interaction = 0.025) and in children born to mothers who smoked during pregnancy (β = −0.48, 95% CI: −0.83, −1.13; P for interaction = 0.027). We concluded that prenatal cadmium exposure was associated with delayed growth in early childhood. Further research is needed to understand cadmium-related sex differences and the role of coexposure to maternal smoking during early pregnancy.

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Low maternal vitamin D status in pregnancy increases the risk of childhood obesity

Abstract: Exposure to very low 25(OH)D concentrations in utero may increase childhood adiposity indices. Given that vitamin D is a modifiable risk factor, our findings may have important public health implications.

Cited by 39 publications

References 29 publications

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

Associations of Prenatal Exposure to Cadmium With Child Growth, Obesity, and Cardiometabolic Traits

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