Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation

Chauhan, Rajni; Tiwari, Aseem Kumar; Aggarwal, Geet; Gowri Suresh, L.; Kumar, Mohit; Bansal, Shyam Bihari

doi:10.1016/j.trim.2023.101931

Transplant Immunology

2023

DOI: 10.1016/j.trim.2023.101931

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Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation

Rajni Chauhan,

Aseem Kumar Tiwari,

Geet Aggarwal

et al.

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2024

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“…DSA and the percentage of panel reactive antibodies (PRA) are the main indicators of antibody-mediated rejection in solid organ transplantation. Recipients with pre-formed DSA have demonstrated an increased risk of early graft loss [1,2]. At the same time, it was shown, that de novo DSA production accelerates graft loss [3,4].Aim.…”

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Donor-Specific Antibodies as a Predictor of Graft Rejection After Liver Transplantation

Kukhol

2024

Biotechnol. acta

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The main reason for graft loss is the rejection of the donor organ, which may occur at different time after transplantation and may be caused by the recipient’s organism reaction against donor’s human leukocyte antigen (HLA) proteins. Donor-specific antibodies (DSA) are produced in patient’s organism as a response to foreign HLA antigens. Aim. The purpose of our study was to evaluate the effects of already existed and/or de novo generated DSAs in liver transplantation as predictors of graft rejection and to establish an interconnection between blood biochemical parameters (Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin level) with the level of DSA in patients with liver transplant. Methods. xMAP-Luminex next generation flow cytometry technology and LABScreen Single antigen beads reagent (Onelambda, USA) were used for antiHLA determination. Total bilirubin level was detected photometrically. The activity of ALT and AST was determined spectrophotometrically on the automatic analyzer COBAS C 111 (Roche, Switzerland) in accordance with the manufacture’s instruction. Results. Detection of DSA and PRA was important at the same level as measurement of classical biochemical parameters of liver function (ALT, AST etc.) for monitoring of graft status and prevention of acute or chronical rejection and choosing correct immunosuppression protocol. Conclusions. The DSA and PRA levels as well as total bilirubin and ALT and AST activity corresponded to each other and could be used for comprehensive both pre- and post-transplantation screening of patients requiring liver transplantation or re-transplantation. Detection of DSA and PRA was important at the same level as measurement of classical biochemical parameters of liver function (ALT, AST etc.) for monitoring of graft status and prevention of acute or chronical rejection and choosing correct immunosuppression protocol.

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Donor-Specific Antibodies as a Predictor of Graft Rejection After Liver Transplantation

Kukhol

2024

Biotechnol. acta

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Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation

Cited by 1 publication

References 19 publications

Donor-Specific Antibodies as a Predictor of Graft Rejection After Liver Transplantation

Donor-Specific Antibodies as a Predictor of Graft Rejection After Liver Transplantation

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