Low modulus Ti–Nb–Hf alloy for biomedical applications

González, M.; Peña, J.; Gil, F.J.; Manero, J. M.

doi:10.1016/j.msec.2014.06.010

Cited by 45 publications

(33 citation statements)

References 21 publications

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“…This value is near to the one reported by Hao et al 26 , who recommended it in order to obtain a low elastic modulus. Moreover, the alloy presents a bond order (BO) of 0.61212 eV and an orbital free energy (OE) of 0.15260 eV which are similar to those obtained by M. Gonzalez et al 20,21 . TEM samples were prepared by the jet-polishing method using Tenupol-3 equipment (Struers, Denmark) in a solution of 350 mL 2-butoxiethanol, 60 mL perchloric acid and 350 mL methanol at 10ºC and 40 V. Thin foils were analyzed by TEM using a JEM 1200 EXII (JEOL, Tokyo, Japan).…”

Section: Alloy Design and Sample Preparationsupporting

confidence: 83%

“…Thus the development of Ti alloys with excellent combination of high strength and low elastic modulus similar to bone values to replace traditional medical metallic alloys are required. Previous studies in our research group 20,21 showed a decrease in the apparent elastic modulus up to 42…”

Section: Introductionmentioning

confidence: 64%

“…Furthermore, these TiNbHf ternary alloys can exhibit very interesting properties since by means of severe plastic deformation (SPD) the mechanical properties could be strongly enhanced 20,21 .…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering

et al. 2015

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Abstract:ABSTRACT Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction with the surrounding tissue avoiding in vivo foreign body reaction. From this perspective, a new Ti-based alloy has been developed with Nb and Hf as alloying elements which are known as non-toxic and with good corrosion properties. The microstructure, mechanical behaviour and the physicochemical properties of this novel titanium alloy have been studied. Relationship of surface chemistry and surface electric charge with protein adsorption and cell adhesion have been evaluated due to its role for understanding the mechanism of biological interactions with tissues. The Ti25Nb21Hf alloy presented a lower elastic modulus than commercial alloys with a superior ultimate strength and yield strength than CP-Ti and very close to Ti6Al4V. It also exhibited good corrosion resistance. Furthermore, the results revealed that it had no cytotoxic effect on rat mesenchymal stem cells and allowed protein adsorption and cell adhesion. The experimental results make this alloy a promising material for bone substitution or for biomedical devices. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 Ti25Nb21Hf alloy presented a lower elastic modulus than commercial alloys with a superior ultimate strength and yield strength than CP-Ti and very close to Ti6Al4V. It also exhibited good corrosion resistance. Furthermore, the results revealed that it had no cytotoxic effect on rat mesenchymal stem cells and allowed protein adsorption and cell adhesion. The experimental results make this alloy a promising material for bone substitution or for biomedical devices.

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Section: Alloy Design and Sample Preparationsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 64%

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Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering

et al. 2015

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“…There are several variations of SPD based techniques such as high pressure torsion (HPT) [53][54][55], equal channel angular pressing (ECAP)/equal channel angular extrusion (ECAE) [56][57][58][59][60], cold rolling [61][62][63][64][65], hot rolling [66][67][68], high energy milling (ball milling) [69][70][71][72][73], sandblasting [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90], and shot peening [91][92][93].…”

Section: Fabrication Of Nanocrystalline Metalsmentioning

confidence: 99%

“…González et al [65] investigated the properties of the new Ti25Nb16Hf alloy (wt.%, vacuum arc-melted, treated at 1,100 °C for 1.5 h and quenched in a mixture of ethanol/water at 0 °C) for biomedical application before and after 95 % cold rolling (95 % C.R.). Rectangular samples of the alloy were cold rolled at room temperature to a 95 % reduction in thickness in a laboratory rolling mill with tool steel work rolls [57].…”

Section: Cold Rollingmentioning

confidence: 99%

Green Techniques for Biomedical Metallic Materials with Nanotechnology

Guo

Tam

2015

Green Processes for Nanotechnology

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From a clinic or medical viewpoint, it is important that the surgical implant retains a combination of high strength (including surface wear resistance), good biocompatibility, and chemical stability. To enable safe interactions between the surgical implants and tissues, surface modification and functionalization are commonly employed.Biological coatings such as TiN and titanium oxides are widely adopted and functionalized with various biological properties such as corrosion resistance, bioactivity, cytocompatibility, and bioconductivity. However, failure of the biological coatings due to the long term corrosion and wear or fretting is the main problem and debris from the materials is the main cause of joint replacement failure. Since the surgical implants are implanted into the human body for a long time, cyclic motions between the surgical implants and human tissues may disrupt the protective biological coatings accelerating corrosion and increasing the risks of immunological response by the leached metallic ions.Therefore, improved metallic biomaterials and the relevant manufacturing techniques are being introduced to meet this demand. Apart from the biocompatibility requirement, metallic biomedical materials also have to meet high standards regarding its performance (functionality, reliability) and selection criteria (cost, manufacturing ability). Up to now, the most often used metallic biomedical materials include stainless steel, cobalt-based alloys, and commercially pure titanium or titaniumbased alloys. However, the implant metallic biomaterials, like all mechanical components, are subjected to degradation and have limited lifetime. Damaged implant requires successive operation to replace worn components and so intensive efforts are made to increase durability of implants metallic biomaterials.For enhancing the mechanical retention, engineered nanostructures on the surface are normally taken to increase effective surface area on implant surfaces (such as both dental and orthopedic applications) to exhibit biological, mechanical, and morphological compatibilities to receiving vital hard/soft tissue, resulting in promoting osseointegration.

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Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

et al. 2021

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Recently, metastable β‐type Ti alloys have attracted attention as promising materials for medical implants due to low Young's modulus and superior biocompatibility. The former is dependent on texture developed during the thermomechanical process. Herein, new Ti–Zr–Nb–Sn–Mo alloys with ultralow Young's modulus and excellent biocompatibility are developed as promising materials for medical implants. The effect of Mo on the microstructure and mechanical properties of the Ti–18Zr–5Nb–3Sn system is investigated. X‐ray diffraction (XRD) and scanning electron microscope (SEM) results reveal that Mo acts as a β‐phase stabilizer. Moreover, mechanical behavior and recrystallization texture show strong composition dependence; the 2.5Mo alloy shows the lowest Young's modulus of 40 GPa. This is due to the formation of a recrystallization texture with strong Goss component of <001>. Corrosion behavior of the 2.5Mo alloy in the cell culture medium is similar to that of the commercially pure titanium (cp‐Ti), suggesting excellent corrosion resistance in the biological environment. Both murine fibroblasts and osteoblastic cells show good growth on the 2.5Mo alloy as the same level of that on the cp‐Ti. Implantation into rat subcutaneous tissue confirms no significant difference in the tissue reaction between the 2.5Mo alloy and the cp‐Ti.

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Low modulus Ti–Nb–Hf alloy for biomedical applications

Cited by 45 publications

References 21 publications

Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering

Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering

Green Techniques for Biomedical Metallic Materials with Nanotechnology

Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

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