Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging

Liu, Gang; Zhi-yong, Wang; Lü, Jian; Xia, Chunchao; Gao, Fabao; Gong, Qiyong; Song, Bin; Zhao, Xüna; Shuai, Xintao; Chen, Xiaoyuan; Ai, Hua; Gu, Zhongwei

doi:10.1016/j.biomaterials.2010.08.099

Cited by 133 publications

(129 citation statements)

References 42 publications

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“…Because of the magnification effect at high field strengths, superparamagnetic nanoparticles can be used to track extremely small numbers of cells for up to several weeks. Previous studies have confirmed that stem cell traffic throughout the body can be noninvasively monitored in MRI by labeling cells with micrometer-sized iron oxide particles or superparamagnetic iron oxides (Mancardi, Saccardi et al 2001;Saiz, Carreras et al 2001;Daldrup-Link, Rudelius et al 2003;Saiz, Blanco et al 2004;Magnitsky, Watson et al 2005;Cheung, Chow et al 2006;Brekke, Williams et al 2007;Roberts, Price et al 2007;Suzuki, Yeung et al 2007;Arbab and Frank 2008;Kraitchman and Bulte 2008;Kraitchman, Gilson et al 2008;Kustermann, Himmelreich et al 2008;Mani, Adler et al 2008;Chapon, Jackson et al 2009;Yamada, Gurney et al 2009;Yang, Liu et al 2009;Drey, Ewert et al 2010;Flexman, Cross et al 2011;Jang, Ye et al 2011;Liu, Wang et al 2011). Yang et al have successfully tracked stem cells following administration to animals with myocardial infarction (MI) and showed that signal attenuation is observed at MI sites for the group of cases with MI (suggesting labeled cells accumulation), while no remarkable signal attenuation is observed for the sham group (Yang, Schumacher et al 2011).…”

Section: Mrimentioning

confidence: 94%

Clinical Stem Cell Imaging and In vivo Tracking

Mirpour¹,

Gholamrezanezhad²

2011

Stem Cells in Clinic and Research

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Section: Mrimentioning

confidence: 94%

Clinical Stem Cell Imaging and In vivo Tracking

Mirpour¹,

Gholamrezanezhad²

2011

Stem Cells in Clinic and Research

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“…Regarding those progresses, several critical issues still remain for applying it in MDR tumor treatment. One issue is that the magnetic properties of iron oxide nanoparticles (e.g., magnetic susceptibility) still require modification with higher sensitivity for cancer detection by MRI 85, 86. The development of T1–T2 dual‐modal contrast agents will potentially solve this drawback, as it can simultaneously provide T1‐weighted imaging with a high tissue resolution and T2‐weighted imaging with a high feasibility, for tumor detection 70, 87.…”

Section: Inorganic Nanocarriers Overcoming Drug Resistance For Cancermentioning

confidence: 99%

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

et al. 2016

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Cancer multidrug resistance (MDR) could lead to therapeutic failure of chemotherapy and radiotherapy, and has become one of the main obstacles to successful cancer treatment. Some advanced drug delivery platforms, such as inorganic nanocarriers, demonstrate a high potential for cancer theranostic to overcome the cancer‐specific limitation of conventional low‐molecular‐weight anticancer agents and imaging probes. Specifically, it could achieve synergetic therapeutic effects, demonstrating stronger killing effects to MDR cancer cells by combining the inorganic nanocarriers with other treatment manners, such as RNA interference and thermal therapy. Moreover, the inorganic nanocarriers could provide imaging functions to help monitor treatment responses, e.g., drug resistance and therapeutic effects, as well as analyze the mechanism of MDR by molecular imaging modalities. In this review, the mechanisms involved in cancer MDR and recent advances of applying inorganic nanocarriers for MDR cancer imaging and therapy are summarized. The inorganic nanocarriers may circumvent cancer MDR for effective therapy and provide a way to track the therapeutic processes for real‐time molecular imaging, demonstrating high performance in studying the interaction of nanocarriers and MDR cancer cells/tissues in laboratory study and further shedding light on elaborate design of nanocarriers that could overcome MDR for clinical translation.

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“…As possibilidades de aplicação envolvem carregadores de drogas, agentes de contraste de imagem em ressonância magnética (ferrofluidos), entre outros. (CHIN et al, 2009;LIU et al, 2011;DANDAMUD e CAMPBELL, 2007;PAN et al, 2005) O objetivo deste estudo é sintetizar e caracterizar nanopartículas de Fe3O4 pelo método de coprecipitação. Pretende-se produzir a nanomagnetita com alto nível de cristalização, homogeneização do tamanho e da dispersão.…”

Section: Introductionunclassified

Síntese E Caracterização De Nanomagnetita Pelo Processo De Coprecipitação

Scapim

Borges

Paula

et al. 2017

JCEC

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RESUMO:A nanomagnetita (Fe3O4) é conhecida por sua propriedade superparamagnética e pelo efeito de superfície característico de materiais nanométricos. As nanopartículas de magnetita foram sintetizadas em laboratório e caracterizadas por difração de raio X (DRX) e microscopia eletrônica de varredura (MEV). A síntese química foi realizada a partir da mistura do cloreto férrico (FeCl3), iodeto de potássio (KI) e solução de amônia (25%), com temperatura e agitação controladas. Foram analisados os resultados do DRX e MEV e comprovado que o material sintetizado foi a nanomagnetita. O método de coprecipitação foi efetivo para a síntese da nanomagnetita.ABSTRACT: Nanomagnetite (Fe3O4) is known by its superparamagnetic property and the surface effect caused by its nanometrics dimensions. The nanoparticles of magnetite were synthesized in laboratory and characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). The chemical synthesis occurred with the mixture of ferric chloride (FeCl3), potassium iodide (KI) and ammonia solution (25%), with controlled temperature and agitation. The results of XRD and SEM were analyzed and it was proved that the synthesized material was nanomagnetite. The coprecipitation method was effective to the nanomagnetite synthesis.

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Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging

Cited by 133 publications

References 42 publications

Clinical Stem Cell Imaging and In vivo Tracking

Clinical Stem Cell Imaging and In vivo Tracking

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

Síntese E Caracterização De Nanomagnetita Pelo Processo De Coprecipitação

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