Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast

Jørgensen, Per Schultz; Warming, Torsten; Hansen, Kim Wadt; Paltved, Charlotte; Berg, Helle Vibeke; Jensen, Ruth Helkiær; Kirchhoff-Jensen, René; Kjær, Lasse; Kerbouche, Nina; Leth-Espensen, Per; Narvestad, Eva; Rasmussen, Søren Wistisen; Sloth, Carsten; Tørholm, C; Wille‐Jørgensen, Peer

doi:10.1016/s0049-3848(02)00059-2

Cited by 122 publications

(119 citation statements)

References 5 publications

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“…Comparison with others is, however, difficult since previous randomized studies (Kujath et al 1993, Kock et al 1995, Jorgensen et al 2002, Lassen et al 2002 have included a heterogeneous mix of patients with different lower limb injuries, treated with or without surgery, factors that may influence the effect of the thromboprophylaxis given and the risk of DVT (Geerts et al 2004). Only 1 of the previous studies (Lassen et al 2002) was placebo-controlled and phlebography was mandatory in only 2 of these studies (Jorgensen et al 2002, Lassen et al 2002. Kujath et al (1993) and Kock et al (1995) used unblinded treatment, and ultrasound to screen for DVT.…”

Section: Discussionmentioning

confidence: 99%

Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: A randomized placebo-controlled, double-blind study

et al. 2007

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BackgroundSkeletal trauma and immobilization are well-known risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE). While prophylaxis against thromboembolic complications has become routine after major orthopedic surgery, whether or not prophylaxis after minor surgery and lower limb immobilization is necessary is still under debate.Methods In a double-blind, placebo-controlled study, 272 consecutive patients were randomized to receive either thromboprophylaxis with Dalteparin (n = 136) or placebo (n = 136) for 5 weeks after ankle fracture surgery. All patients received 1 week of initial treatment with Dalteparin before randomization. A unilateral phlebography was performed when the cast was removed.Results The overall incidence of DVT was 21% (95% CI: 13-29%) in the Dalteparin group and 28% (CI: 19-37%) in the placebo group (risk ratio = 0.8, CI: 0.6-1.1; p = 0.3). The incidence of proximal DVTs was 4% and 3%, respectively. No major bleeding occurred.Interpretation We found no significant difference in the incidence of DVT between the 2 treatment groups and our results do not support prolonged thromboprophylaxis. The overall incidence of DVT was high, reflecting the potential risk of PE and post-thrombotic syndrome after ankle fracture surgery. Most of the DVTs were asymptomatic, however, and were located in distal veins.

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Section: Discussionmentioning

confidence: 99%

Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: A randomized placebo-controlled, double-blind study

et al. 2007

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“…[6,[8][9][10][11][12][13][14][15][16][17][18][19][20]26,37,41] A difficulty of long-term follow-up of patients is that many DVT events occur several weeks or longer after discharge. [37,42] …”

Section: Researchmentioning

confidence: 99%

The benefit of pharmacological venous thromboprophylaxis in foot and ankle surgery

et al. 2017

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“…The risk of thromboembolism after acute achillies tendon rupture has been demonstrated in several studies [4][5][6]. Venous thromboembolism was demonstrated in 34% patients, two months after an acute total Achilles tendon rupture [2].…”

Section: Discussionmentioning

confidence: 95%

Acute presentation of deep vein thrombosis in Achilles tendon rupture: A case report

Yassa¹,

Kandola²,

Sharma³

2013

IJCRI

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Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast

Cited by 122 publications

References 5 publications

Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: A randomized placebo-controlled, double-blind study

Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: A randomized placebo-controlled, double-blind study

The benefit of pharmacological venous thromboprophylaxis in foot and ankle surgery

Acute presentation of deep vein thrombosis in Achilles tendon rupture: A case report

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