Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors

Shi, Yao; Qian, Jie; Zhang, Feng; Jia, Beibei; Liu, Xiaoyan; Hu, Yan; Zhang, Qinfen; Yang, Ye; Sun, Dongdong; Jiang, Li

doi:10.3892/mmr.2019.10868

Cited by 7 publications

(7 citation statements)

References 44 publications

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“…In our study, both LMWH and LMWH + ASA as anticoagulants were studied. While the studies on the preventive effect of LMWH on GDM increased [18,19], the studies on ASA mainly prevent the cardiac complications that may happen in pregnant women [23,24]. Our analysis shows no significant statistical difference between LMWH or LMWH + ASA usage in GDM development.…”

Section: Discussionmentioning

confidence: 58%

“…This was done by repressing the nuclear factorkappa B signal and inhibiting the AGE-RAGE signal pathway. The study results showed that protecting the placental barrier in GDM could represent a new target in treatment and that LMWH could be a potential drug for treatment [19]. Other studies confirm that LMWH has an antagonistic effect on the RAGE axis.…”

Section: Discussionmentioning

confidence: 72%

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Use of Anticoagulants During Pregnancy Prevent Gestational Diabetes?

Azhari¹,

Eren²,

Gurer³

et al. 2022

Act Sci wom hea

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Background: Nowadays, the use of anticoagulants during pregnancy has increased It is used nearly in all of the advanced maternal age and multifetal pregnancies. It is important to study the effects of this increasingly popular treatment modality on other diseases.The purpose of this study is to research the effect of the usage of anticoagulants on the prevalence of gestational diabetes. Material and Methods:Our study is retrospective. The participants consist of a group of pregnant women. Pregnant women using anticoagulants formed the case, and randomly selected pregnant women not using anticoagulants formed the control group. The study consisted of 800 participants, 400 case and 400 control. The descriptive statistics are age, number of pregnancies and body mass index. A Chi-Square test was performed to study the effect of the usage of anticoagulants on gestational diabetes. Results:Other than the body mass index of the groups, other descriptive statistics are similar There was no relationship between the participants with and without gestational diabetes in the case group in terms of gestational age, number of pregnancies and body mass index (p > 0.05). In the control group, statistically significant relationship was found (p < 0.01). A statistically significant relationship was found between the case and control groups in terms of gestational diabetes frequency (p < 0.01). Conclusions:Our study is one of the first studies to research the effect of anticoagulants had on the development of gestational diabetes. The findings of our study show that the usage of anticoagulants decrease the gestational diabetes development rate.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 72%

Use of Anticoagulants During Pregnancy Prevent Gestational Diabetes?

Azhari¹,

Eren²,

Gurer³

et al. 2022

Act Sci wom hea

View full text Add to dashboard Cite

show abstract

“…The results presented here are similar to those of another recent study that investigated GDM rats and showed a significant increase in serum VEGF-A level and advanced glycation end-products (AGEs) concentrations. 22 The potential mechanism(s) for increase VEGF-A level might be that AGEs perform their harmful effects, whether by actively destroying cells or by binding to the receptor of advanced glycation end-products (RAGE). As binding AGEs with RAGE enhances activation of the NF-kB pathway and increases VEGF production, rendering this significant mechanism underlying malfunction at the placental barrier of GDM.…”

Section: Discussionmentioning

confidence: 99%

Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes

Al-ofi

Alrafiah

Maidi

et al. 2021

IJGM

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Background: Gestational diabetes mellitus (GDM) typically occurs during the third trimester of pregnancy. Maternal hyperglycemic may influence the expression of pro-and antiangiogenic factors. Altered levels of angiogenic biomarkers in GDM pregnant women are associated with abnormal placentation. This study aimed to investigate the rates of expression of five angiogenic biomarkers called vascular endothelial growth factor-A (VEGF-A), angiopoietin-2, endoglin, endothelin-1, and granulocyte colony-stimulating factor (G-CSF) in GDM. Methods: The samples were obtained from normal (n=9) and GDM (n=10) pregnancies. Multiplex assay was used to assess the levels of angiogenic biomarkers including VEGF-A, endoglin, endothelin-1, angiopoietin-2, and G-CSF in serum samples. All data were statistically analyzed using an unpaired Student's t-test. Correlations between measured parameters were made using Pearson correlations. Results: VEGF-A, endoglin, endothelin-1, and angiopoietin-2 levels in GDM were significantly higher (P value = 0.001, 0.042, 0.049, 0.001; respectively) compared to control. However, G-CSF level exhibited a non-significant increase (P=0.466) in GDM compared to healthy controls. There was a significant positive correlation between angiopoietin-2 with endoglin, endothelin-1, and VEGF-A. Moreover, there was a significant positive correlation between VEGF-A with endoglin and endothelin-1. Most interestingly, there was a significant positive correlation between G-CSF with endothelin-1. Conclusion:The angiogenic biomarkers were highly altered in pregnant women with GDM.The study provides a novel advance in the field of gestational diabetes, in terms of increase of angiogenic factors that can modify the vascularization of the placenta, the development of fetal vascular system and the insulin resistance itself.

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“…In keeping with our earlier statement, that barrier leak in diabetes is systemic and across many tissue types, diabetes-associated hyposalivation was shown to associate with altered TJ protein expression in parotid glands [ 23 ]. In addition, gestational diabetes in a rat model induced increased leak across the placental barrier along with decreased ZO-1 and occludin expression [ 238 ].…”

Section: Is Epithelial Barrier Compromise a Common Occurrence In Dise...mentioning

confidence: 99%

Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

DiGuilio

Rybakovsky

Abdavies

et al. 2022

IJMS

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The published literature makes a very strong case that a wide range of disease morbidity associates with and may in part be due to epithelial barrier leak. An equally large body of published literature substantiates that a diverse group of micronutrients can reduce barrier leak across a wide array of epithelial tissue types, stemming from both cell culture as well as animal and human tissue models. Conversely, micronutrient deficiencies can exacerbate both barrier leak and morbidity. Focusing on zinc, Vitamin A and Vitamin D, this review shows that at concentrations above RDA levels but well below toxicity limits, these micronutrients can induce cell- and tissue-specific molecular-level changes in tight junctional complexes (and by other mechanisms) that reduce barrier leak. An opportunity now exists in critical care—but also medical prophylactic and therapeutic care in general—to consider implementation of select micronutrients at elevated dosages as adjuvant therapeutics in a variety of disease management. This consideration is particularly pointed amidst the COVID-19 pandemic.

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Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors

Cited by 7 publications

References 44 publications

Use of Anticoagulants During Pregnancy Prevent Gestational Diabetes?

Use of Anticoagulants During Pregnancy Prevent Gestational Diabetes?

Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes

Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

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