Low molecular weight heparins: are they interchangeable? No

Nenci, Giuseppe G.

doi:10.1046/j.1538-7836.2003.00017.x

Cited by 41 publications

(25 citation statements)

References 15 publications

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“…The statistically significant findings of Hyun et al . showed high levels of sVCAM-1 in patients with operable breast cancer and metastasis [26]. Similar findings, regarding sICAM-1 and sVCAM-1, were found in the cases of patients with stomach cancer in the study by Yoo et al .…”

Section: Discussionsupporting

confidence: 69%

The clinical usefulness of assessing the concentration of cell adhesion molecules sVCAM-1 and sICAM-1 in the serum of women with primary breast cancer

Thielemann

Baszczuk

Kopczyński

et al. 2014

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Aim of the studyAssessment of the concentrations of the soluble forms of the cell adhesion molecules sVCAM-1 and sICAM-1 in serum of female breast cancer patients. These concentrations were assessed in relation to factors such as: age, clinical stage of disease, histological grade of malignancy, the status of the local axillary lymph nodes, and the size of the primary tumour.Material and methodsA total of 103 patients with primary breast cancer, aged 29 to 89 years, were investigated. The control group consisted of 40 healthy women. The concentration of sVCAM-1 and sICAM-1 was assessed using an enzyme-linked immunosorbent assay (ELISA).ResultsThe results of the study suggest that the level of sVCAM-1 and sICAM-1 in the serum of women with breast cancer was significantly higher than that seen in the serum of healthy women. A relationship between the level of adhesion molecules and the stage of clinical disease advancement was discovered. There was a correlation between the increasing concentrations of sVCAM-1 and sICAM-1 and with the aggressiveness of the disease. Significant differences were also found in the group of women with metastases to the axillary lymph nodes and women with no metastasis. Similar correlations were found between sVCAM-1 and sICAM-1 levels and the size of primary tumour.ConclusionsThe results obtained suggest that the assessment of the soluble forms of sVCAM-1 and sICAM-1 may be useful indicators in the assessment of the clinical advancement of breast cancer.

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Section: Discussionsupporting

confidence: 69%

The clinical usefulness of assessing the concentration of cell adhesion molecules sVCAM-1 and sICAM-1 in the serum of women with primary breast cancer

Thielemann

Baszczuk

Kopczyński

et al. 2014

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“…Marine environment is characterized by extreme physicochemical conditions and harbours unusual microbes with potential of different biotechnological applications. Hence, in order to survive in such conditions marine microbes follow some unique biochemical pathways resulting in the production of novel bioactive compounds including, exopolysaccharides [1], [2]. More importantly, marine microbes tend to have significant osmotic tolerance leading to their capability of polysaccharide production at higher sugar concentration, which is very much desired for development of an economically feasible process for polysaccharide production.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Polysaccharide Production by a Novel Osmotolerant Marine Strain of Alteromonas macleodii and Its Application towards Biomineralization of Silver

et al. 2014

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The present study demonstrates exopolysaccharide production by an osmotolerant marine isolate and also describes further application of the purified polysaccharide for production of colloidal suspension of silver nanoparticles with narrow size distribution. Phylogenetic analysis based on 16S r RNA gene sequencing revealed close affinity of the isolate to Alteromonas macleodii. Unlike earlier reports, where glucose was used as the carbon source, lactose was found to be the most suitable substrate for polysaccharide production. The strain was capable of producing 23.4 gl−1 exopolysaccharide with a productivity of 7.8 gl−1 day−1 when 15% (w/v) lactose was used as carbon source. Furthermore, the purified polysaccharide was able to produce spherical shaped silver nanoparticles of around 70 nm size as characterized by Uv-vis spectroscopy, Dynamic light scattering and Transmission electron microscopy. These observations suggested possible commercial potential of the isolated strain for production of a polysaccharide which has the capability of synthesizing biocompatible metal nanoparticle.

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“…Based on their different pharmacological and therapeutic profiles, LMWHs are largely considered by the experts and regulatory agencies such as the US FDA to be distinct drugs requiring indication and dosage specifications for each product. Therapeutic and generic interchanges are not recommended among different LMWHs, as this may compromise medical and surgical patient care [1]. The differences among the LMWHs are due to their molecular and structural properties.…”

mentioning

confidence: 99%

“…Both the biological and pharmacological differences impact on the clinical safety and efficacy of each LMWH. The clinical performance of enoxaparin, dalteparin, and nadroparin has been differentiated in various settings [1,6]. Levels of evidence also exist relating to the variable effects of different LMWHs on specific patient populations, e.g., patients with renal impairment.…”

mentioning

confidence: 99%