Low Molecular Weight Poly(Lactide-<i>co</i>-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management

Abstract

The use of biopolymers as bioadhesives for human tissue is becoming a preferred alternative to suturing due to their superior adhesive, biocompatible, and biodegradable properties. In this work, low molecular weight poly(L-lactide-co--caprolactone) (P(LA-co-CL) was synthesized to achieve the glass transition temperature (T g ) of the copolymer at ambient temperature so that during application on the skin, the copolymer when combined with chitosan (CHI) into the CHI/P(LA-co-CL) film could provide the strong support at the injury site. Using alcohols with different numbers of hydroxyl groups as the co-initiator in polymerization provided the distinctive characteristics of copolymers. Among all copolymers synthesized, P(LA-co-CL) copolymer using pentaerythritol as the co-initiator when combined with CHI at the ratio of copolymer/CHI at 70/30 yielded the good film properties in tissue adhesion and tetracycline hydrochloride release.

Organoaluminium Complexes Derived from Anilines or Schiff Bases for the Ring‐Opening Polymerization of ε‐Caprolactone, δ‐Valerolactone and rac‐Lactide

“…The highest percentage incorporation of LA was found for 1 (62.6 %). The observed molecular weights (3680–6670) are best described as low to moderate; however, we note there is interest in low molecular weight poly(lactide/caprolactone) polymers as bio‐adhesives . Thermal analysis of the co‐polymers by differential scanning calorimetry (DSC) revealed two melting points at 55.7 °C (PCL) and 125.9 °C (PLA), see Figure S22.…”

Ring opening polymerization of lactides and lactones by multimetallic alkyl zinc complexes derived from the acids Ph2C(X)CO2H (X = OH, NH2)

“…2 Furthermore, given the differing properties that can be associated with both PCL and PLA, there is interest in 3-Cl/LA copolymers of varying compositions; low molecular weight 3-Cl/LA copolymers have been employed as bio-adhesives. 3 In terms of control, as well as judicious choice of metal centre, it has become clear that the ligand set can also play a pivotal role in determining the catalytic behaviour of the ROP system. Chelating N,O-or O,O-ligand sets have shown great potential.…”

Fabrication and Evaluation of Polycaprolactone/Gelatin‐Based Electrospun Nanofibers with Antibacterial Properties

“…In cases of full-thickness burns or deep ulcers, there are no remaining sources of cells for tissue regeneration and recovery [1]. These severely injured parts will deteriorate further if a patient has diabetes [2]. Hence, tissue engineering (TE) technology is crucial to solve this issue.…”

“…However, there is less research on the antibacterial testing of PCL/GE nanofibers for the application of skin tissue regeneration. It is essential to apply antibiotic to the severely injured part of the skin via a drug delivery system to reduce inflammation caused by bacterial infection [20]. Therefore, it is important to fabricate an antibacterial test for PCL/GE-based nanofibers to avoid the interference of bacteria with cell activities during tissue regeneration and repair.…”