Low n‐6/n‐3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n‐3 Fatty Acid Source

Li, Yang; Song, Zhi Xiu; Yin, Hong; Wang, Yan Yan; Shu, Guo Fang; Lü, Hui; Wang, Shao Kang; Sun, Gui Ju

doi:10.1007/s11745-015-4091-z

Cited by 127 publications

(92 citation statements)

References 58 publications

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“…No studies nity processes. It has been recently demonstrated that high seric levels in n-6/n-3 PUFA ratio induce health benefits while lower ratios might develop adverse effects [42]. In this sense obtained data might reflect possible exercise-induced adverse conditions in sportsmen.…”

Section: Discussionmentioning

confidence: 94%

Long-Term Adaptations to Aerobic-Anaerobic Physical Training in the Erythrocyte Membrane Fatty Acids Profile

Iglesias¹

2017

Int J Sports Exerc Med

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Aim: The aim of this survey is to examine the effects of physical training on erythrocyte membrane fatty acids percentages as well as to analyze cellular adaptations in young sportsmen.Methods: Forty-four male volunteers participated: a group of 22 Trained players (TG) (age: 17.86 ± 0.36 years; weight: 69.86 ± 4.53 Kg; height: 1.78 ± 0.54 m), with a regular football training plan of 10 hours/week, and a group of 22 Untrained participants (UG) (age: 18.23 ± 0.49 years; weight: 72.10 ± 8.56 Kg; height: 1.68 ± 0.39 m). Gas chromatograph HP-5890 Series II was used to determine fatty acids concentrations. Results:Higher levels were obtained in the TG group in C12:0 (0.31 ± 0.35 vs. 0.03 ± 0.04%, P < 0.001) and in n-6/n-3 index (8.74 ± 5.20 vs. 4.29 ± 1.09, P < 0.001), and lower values in C22:6 (3.00 ± 3.51 vs. 5.08 ± 1.44%, P < 0.01) in comparison with the UT group. Moreover, a correlation of these parameters and the Lipid Peroxidation index with training degree were observed. Conclusion:10 hours/week aerobic-anaerobic football training program produces C12:0, n-6/n-3 index, C22:6 modifications in erythrocyte membrane.

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Section: Discussionmentioning

confidence: 94%

Long-Term Adaptations to Aerobic-Anaerobic Physical Training in the Erythrocyte Membrane Fatty Acids Profile

Iglesias¹

2017

Int J Sports Exerc Med

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“…For this reason, FAO (2010) [28] recommends ingestion of ω-6 between 2.5-9% and ω3 between 0.5-2%. Appropriate consumption of those fatty acids helps regulating the inflammatory process, oxidative stress and endothelial function [29].…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization of Oils and Fats from Amazonian Fruits by <sup>1</sup>H NMR

Santos¹,

Filho²,

Chagas³

et al. 2017

Preprint

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Native plants from the Brazilian Amazon Biome are rich in nutrientes, oils and fats and, therefore, represent a very important regional food resource. Althoung there is a global interest in the nutritional potential of tropical fruits, the potential of Amazonian fruits as source of essential fatty acids is still under exploited, since their composition is still understudied. 1 H Magnetic Resonance Nuclear ( 1 H NMR) is a robust spectroscopic tool to profile fatty acids components in oils. The objectives of this work were to use 1 H NMR to determine the fatty acids profile and the physicochemical properties of crude oils and fats obtained from fruits of Brazilian Amazon: açaí, ata-brava, bacaba, buriti, buritirana, murici amarelo, murici vermelho, piaçaba braba, tucumanzinho, pupunha red and yellow varieties. Oils were obtained by Soxhlet extraction using hexane as a solvent. After solvent removal by rotoevaporation, the resulting oils and fats were analyzed by 1 H NMR spectroscopy. Unsaturated fatty acids oleic (ω9), linoleic (ω6) and linolenic (ω3) acids were quantified in the oils and their physicochemical properties were determined. It was observed that the oils have predominately ω9 fatty acids, followed by ω6 and ω3 representatives. The physicochemical properties confirmed edibility and good quality of oils and fats present in the aforementioned Amazonian fruits.

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“…They found that EPA effectively prevented the development and progression of NASH and ameliorated hepatic steatosis in mice [22]. Heerwagen et al revealed that a highfat diet significantly increased the n-3:n-6 PUFA ratio and reduced maternal obesity-associated inflammation in Fat-1 transgenic mice.…”

Section: Discussionmentioning

confidence: 99%

Supplementation With 2:1 Ratio of N-6:n-3 Polyunsaturated Fatty Acid Improves Liver Steatosis and Serum Cytokine Levels in Young Obese Balinese Women: A Randomized Clinical Trial

Weta

Mahadewa

Sutirtayasa

et al. 2017

Asian J Pharm Clin Res

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Objectives: In addition to the rise in obesity prevalence globally, morbidity due to nonalcoholic fatty liver disease is increasing. Primary modalities for preventing and managing this problem include dietary modification and improved physical activities. A daily diet with a low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio is suspected to contribute to ameliorating liver steatosis (LS). The present study was conducted to elucidate the effects of an n-6:n-3 PUFA ratio of 2:1 in alleviating LS.Methods: Twenty-four young obese women with LS were recruited from Denpasar, Bali, Indonesia. They were randomly allocated to an intervention or control group. Both groups were given linoleic acid:α-linolenic acid at ratios of 2035:970 and 240:100 g, respectively, for 12 weeks. Baseline and end-line data were obtained. All patients were advised to maintain their daily energy intake no more than 1500 kcal and to perform structured physical exercises once a week. Results:The intervention significantly decreased the body fat (body mass index, p=0.040; triglyceride, p=0.008) and serum tumor necrosis factor-α (TNF-α) levels (p=0.002) and increased serum interleukin-10 (IL-10) levels (p=0.004). The severity of LS was reduced through the intervention (odds ratio=0.064; 95% confidence interval=0.013-0.310; p=0.001).Conclusion: An increased intake of 2:1 n-6:n-3 PUFA ratio alleviated LS, decreased body fat composition and serum TNF-α levels, and increased serum IL-10 levels.

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Low n‐6/n‐3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n‐3 Fatty Acid Source

Cited by 127 publications

References 58 publications

Long-Term Adaptations to Aerobic-Anaerobic Physical Training in the Erythrocyte Membrane Fatty Acids Profile

Long-Term Adaptations to Aerobic-Anaerobic Physical Training in the Erythrocyte Membrane Fatty Acids Profile

Chemical Characterization of Oils and Fats from Amazonian Fruits by <sup>1</sup>H NMR

Supplementation With 2:1 Ratio of N-6:n-3 Polyunsaturated Fatty Acid Improves Liver Steatosis and Serum Cytokine Levels in Young Obese Balinese Women: A Randomized Clinical Trial

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