Low-Normal Lung Volume Correlates With Pulmonary Hypertension in Fibrotic Idiopathic Interstitial Pneumonia: Computer-Aided 3D Quantitative Analysis of Chest CT

Iwasawa, Tae; Kato, Shingo; Ogura, Takashi; Kusakawa, Yuka; Iso, Shinichiro; Baba, Tomohisa; Fukui, Kazuki; Oba, Mari S.

doi:10.2214/ajr.13.11409

Cited by 18 publications

(15 citation statements)

References 34 publications

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“…PVV was also found to be a more malignant prognostic determinant in patients with increased fibrosis on CT. Regarding the visual CT variables that were independently predictive of mortality, traction bronchiectasis severity [23e26] and the pulmonary artery diameter [27,28] have both been previously shown to strongly predict outcome across various fibrosing lung diseases, but were not examined in previous studies investigating uILD [4,29].…”

Section: Discussionmentioning

confidence: 99%

Unclassifiable-interstitial lung disease: Outcome prediction using CT and functional indices

Jacob

Bartholmai

Rajagopalan

et al. 2017

Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Unclassifiable-interstitial lung disease: Outcome prediction using CT and functional indices

Jacob

Bartholmai

Rajagopalan

et al. 2017

Respiratory Medicine

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“…Disagreements between the two radiologists after the first assessment were resolved by discussion. We also used computer-aided 3D quantitative analysis of chest HRCT to automatically categorize the lungs in the 3D CT images pixel-by-pixel with Gaussian histogram-normalized relations, and relative volume of disease extent (%) to HRCT lung volume was calculated [26, 27]. A previous study reported that an easily applicable, limited/extensive disease staging system for SSc-ILD based on combined evaluation with HRCT and pulmonary function testing (PFT) provides discriminatory prognostic information [28].…”

Section: Methodsmentioning

confidence: 99%

Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis

et al. 2016

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BackgroundPatients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD.ObjectiveThis study was conducted to elucidate the characteristics, prognosis, and disease behavior in patients with interstitial lung disease (ILD) associated with systemic sclerosis (SSc)-related autoantibodies.MethodsWe retrospectively analyzed medical records of 72 ILD patients: 40 patients with SSc (SSc-ILD) and 32 patients with SSc-related autoantibody-positive ILD but not with CTD (ScAb-ILD), indicating lung-dominant CTD with SSc-related autoantibody.ResultsPatients with SSc-ILD were predominantly females and non-smokers, and most had nonspecific interstitial pneumonia confirmed by high-resolution computed tomography (HRCT) and pathological analysis. However, about half of the patients with ScAb-ILD were male and current or ex-smokers. On HRCT analysis, honeycombing was more predominant in patients with ScAb-ILD than with SSc-ILD. Pathological analysis showed the severity of vascular intimal or medial thickening in the SSc-ILD patients to be significantly higher than that in the ScAb-ILD patients. Survival curves showed that the patients with ScAb-ILD had a significantly poorer outcome than those with SSc-ILD.ConclusionData from this study suggest that lung-dominant CTD with SSc-related autoantibody is a different disease entity from SSc-ILD.

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“…Disease extent (%) on HRCT was calculated by a three-dimensional computeraided system (i.e., Gaussian histogram normalized correlation) of CT images (24,25). Pathological analysis was classified according to the current classification of idiopathic interstitial pneumonias by two pulmonary pathologists (T.T.…”

Section: Study Samplementioning

confidence: 99%

Serum KL-6 and surfactant protein-D as monitoring and predictive markers of interstitial lung disease in patients with systemic sclerosis and mixed connective tissue disease

Yamakawa¹,

Hagiwara²,

Kitamura³

et al. 2017

J. Thorac. Dis.

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Low-Normal Lung Volume Correlates With Pulmonary Hypertension in Fibrotic Idiopathic Interstitial Pneumonia: Computer-Aided 3D Quantitative Analysis of Chest CT

Abstract: The relative CT volume of any single lesion was of limited value in predicting pulmonary hypertension in patients with pulmonary fibrosis and emphysema. In these patients, normal(%), measured by a 3D computer-aided system, was correlated with pulmonary hypertension measured by RHC.

Cited by 18 publications

References 34 publications

Unclassifiable-interstitial lung disease: Outcome prediction using CT and functional indices

Unclassifiable-interstitial lung disease: Outcome prediction using CT and functional indices

Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis

Serum KL-6 and surfactant protein-D as monitoring and predictive markers of interstitial lung disease in patients with systemic sclerosis and mixed connective tissue disease

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