Low numbers of interleukin‐12‐producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood

Nilsson, Caroline; Larsson, Anna‐Karin; Höglind, Ankie; Gabrielsson, Susanne; Blomberg, Marita Troye; Lilja, G.

doi:10.1111/j.1365-2222.2004.01896.x

Cited by 32 publications

(26 citation statements)

References 37 publications

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“…an increased interleukin (IL)-4 to interferon (IFN)-γ ratio and lower numbers of IL-12-producing cells than CBMC obtained from children born to non-atopic mothers [2]. In a follow-up study, when the same children were evaluated on basis of their immunoglobulin E (IgE)-sensitization status at the age of 2 years, our data revealed that there was no correlation between an increased cord blood IL-4 : IFN-γ ratio and the development of early atopy [3]. Rather, our data showed that children developing early IgE-sensitization had fewer IL-12-producing CBMC compared to their non-sensitized counterparts.…”

Section: Introductionmentioning

confidence: 61%

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Larsson

Nilsson

Höglind

et al. 2006

Clinical and Experimental Immunology

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SummaryLittle is known at present about the relation between parental and child cytokine profiles. In this study we aimed to investigate the cytokine profile of 2-year-old children and their corresponding mothers, 2 years after delivery. Peripheral blood mononuclear cells (PBMC) were isolated from IgEsensitized ( n = = = = 15) and non-sensitized ( n = = = = 58) 2-year-old children and their mothers. The responses to ovalbumin, cat and phytohaemagglutinin (PHA) were investigated using the enzyme-linked immunospot (ELISpot) technique. Interferon (IFN)-γ γ γ γ -, interleukin (IL)-4-, IL-10-and IL-12-producing cells were enumerated. At 2 years of age, IgE-sensitized children exhibited increased numbers of IL-4-producing cells in response to PHA and also showed an increase in IL-10-and IL-12-producing cells to allergen that was more pronounced in response to ovalbumin than to cat. A statistically significant increase in the numbers of IFN-γ γ γ γ -, IL-10-and IL-12-producing cells to the allergens, but not to PHA, was found in the mothers of IgE-sensitized children irrespective of their own atopic status. IgE levels and cytokine responses were correlated between the mothers and their children, indicating that cytokine responses to both allergen and PHA might be governed by genetic factors. We speculate that the increased cytokine response to allergen, as opposed to the allergic status of the mother, might be a better predictor and/or a risk factor for the child to develop IgE-sensitization in early life.

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Section: Introductionmentioning

confidence: 61%

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Larsson

Nilsson

Höglind

et al. 2006

Clinical and Experimental Immunology

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“…This Th2 bias is usually considered to be a major underlying mechanism for the development of atopy in early life, and could again be a consequence of APC defects. Supporting this concept, low numbers of IL-12-producing cells have been observed in neonates with inherited atopic disease [88,89], as well as low LPS-induced production of IL-12 in children who develop atopic diseases compared to children who do not [90]. The baseline expression of HLA Class II on CB monocytes is lower in children in whom allergic diseases developed within the first two years of life [91].…”

Section: The Immune Response In Early Childhood Yearsmentioning

confidence: 94%

Defective antigen-presenting cell function in human neonates

Velilla¹,

Rugeles²,

Chougnet³

2006

Clinical Immunology

153

132

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Immaturity of the immune system has been suggested as an underlying factor for the high rate of morbidity and mortality from infections in newborns. Functional impairment of neonatal T cells is frequently quoted as the main underlying mechanism for such immaturity. However, recent studies suggest that neonatal antigen-presenting cells (APCs) also exhibit functional alterations, which could lead to secondary defects of adaptive T cell responses. In this review, we summarize what is known on the functionality of APC at birth and during early childhood. Compared to adults, neonatal APCs display markers of immaturity and produce low levels of cytokines. Multiple factors could be involved in neonatal APC alteration, such as intrinsic immaturity, defective interaction between APCs and T cells, and regulatory T cell-mediated inhibition. Characterization of the relative contribution of each mechanism is clearly needed to better understand the functional capability of the neonatal immune system.

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“…and IFN-γ-producing CBMCs and lower IFN-γ secretion after allergen stimulation have been associated with development of allergic symptoms and sensitisation later in life [174,175,201]. The discrepant immune response at birth, might be associated with exposure to a strong Th2 environment in utero.…”

Section: Postnatal Development Of the Immune Systemmentioning

confidence: 99%

Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

Abelius¹

2014

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Low numbers of interleukin‐12‐producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood

Cited by 32 publications

References 37 publications

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Defective antigen-presenting cell function in human neonates

Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

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