Plastic products with tremendous consumption are ubiquitous in our daily lives and the annual production of plastics is drastically increasing [1]. It is now expected to reach 33 billion tonnes by 2050 [2] with plastic waste in the environment projected to reach 67.8 million metric tons by the same year [3]. The pollution of plastic cum microplastics (MPs) from degradation in the environment is currently a hot issue attracting the global attention of many scientists, governmental and non-governmental organization and the public media [3-7]. Although few studies have investigated the chemical behavior and toxicity of MPs in the natural environment, studies focusing on its toxicity in tandem with toxic chemicals to ecosystems are scarce [1,4,8]. There are many toxicology reports that MPs are harmful to ecosystems. Terrestrial organisms such as earthworms, soil collembolans, and other animals, as well as plants have been affected by MPs [1,4,9-13]. Also, aquatic organisms such fish, sandhoppers, sea turtle, crustacean and mussel have also been affected by MPs [14-15]. In addition, humans are exposed to MPs via trophic transfer or by direct ingestion, contact and inhalation and plausible effects include lung inflammation and genotoxicity may occur [1,3,16,17]. Aside from the innate toxicity of MPs, they can carry different toxic chemicals such as heavy metals and organic pollutant by adsorption process, and double the effect of such pollutants [1,8,18]. Succinctly, plastic products are made up of mixtures of polymers, fillers, and multiple additives to improve its usability. Also, there are other chemicals including unreacted monomers, starting substances and non-intentionally added substances (NIAS; impurities, side or breakdown products) that are also present in plastic. However, most of these chemicals are not covalently bound to the polymer, so they can be released at all stages of the plastics' life cycle via migration to liquids or solids or via volatilization [1]. Therefore, plastic materials are an important source of human exposure to chemicals.