Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples

Abstract

The ultimate objective of this research work is to design a sensitive and selective electrochemical sensor for the efficient detection of ascorbic acid (AA), a vital antioxidant found in blood serum that may serve as a biomarker for oxidative stress. To achieve this, we utilized a novel Yb2O3.CuO@rGO nanocomposite (NC) as the active material to modify the glassy carbon working electrode (GCE). The structural properties and morphological characteristics of the Yb2O3.CuO@rGO NC were investigated using various techniques to ensure their suitability for the sensor. The resulting sensor electrode was able to detect a broad range of AA concentrations (0.5–1571 µM) in neutral phosphate buffer solution, with a high sensitivity of 0.4341 µAµM−1cm−2 and a reasonable detection limit of 0.062 µM. The sensor’s great sensitivity and selectivity allowed it to accurately determine the levels of AA in human blood serum and commercial vitamin C tablets. It demonstrated high levels of reproducibility, repeatability, and stability, making it a reliable and robust sensor for the measurement of AA at low overpotential. Overall, the Yb2O3.CuO@rGO/GCE sensor showed great potential in detecting AA from real samples.

Fabrications of the Flexible Non-Enzymatic Glucose Sensors Using Au-CuO-rGO and Au-CuO-rGO-MWCNTs Nanocomposites as Carriers

“…Ahmed et al employed a Yb 2 O 3 .CuO@rGO nanocomposite as the active substance to enhance the glassy carbon working electrode. This approach was employed to create a highly sensitive and selective electrochemical sensor for the efficient detection of ascorbic acid [26]. So far, there are few studies using Au-CuO-rGO and Au-CuO-rGO-MWCNTs nanocomposites and changing the content of MWCNTs as sensing devices.…”