Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ

Kruse, Arnold‐Jan; Skaland, Ivar; Munk, Ane Cecilie; Janssen, Emiel A. M.; Gudlaugsson, Einar; Baak, J. P. A.

doi:10.1016/j.humpath.2007.08.014

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…For p16, Ki67, CD4, CD8, CD25, CD138 and FOXp3, the interpretation was done according to a previous described protocol 10. The epithelium was subjectively divided into two layers, an upper and a lower half, and all biomarkers were assessed in each half separately as described previously 15. The stroma adjacent to the basal membrane was evaluated in a strip measuring 500 μm deep below the epithelial basal membrane.…”

Section: Methodsmentioning

confidence: 99%

The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2–3

et al. 2011

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Section: Methodsmentioning

confidence: 99%

The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2–3

et al. 2011

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“…The epithelium was subjectively divided into two layers, an upper and a lower half, and all biomarkers were assessed in each half separately as described previously. 23 The stroma adjacent to the basal membrane was evaluated in a strip measuring 500 mm deep below the epithelial basal membrane. This was performed by using a Â 40 objective with a field diameter of 520 mm and by viewing the membrane just visible in the outermost part of the field of vision.…”

Section: Semi-quantitative Scoring Of the Immunohistochemical Staininmentioning

confidence: 99%

Local immune response in the microenvironment of CIN2–3 with and without spontaneous regression

et al. 2010

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Fifteen to thirty percent of cases with histologically confirmed CIN2-3 in cervical biopsies regress spontaneously (ie, show CIN1 or less in the follow-up cervical cone). The balance between immune-reactive cells from the host and high-risk human papillomavirus (hrHPV) genotypes may provide a biological explanation for this phenomenon. We retrospectively studied 55 cases of CIN2-3 in a cervical biopsy with subsequent cervical cone to assess whether hrHPV genotypes (by AMPLICOR and Linear Array tests) CD4, CD8, CD25, CD138 and Foxp3 cells (by quantitative immunohistochemistry) in the cervical biopsies can predict regression (defined as CIN1 or less in the follow-up cone biopsy). Eighteen percent of the CIN2-3 cases regressed (median biopsy-cervical cone time interval: 12.0 weeks, range: 5.0-34.1 weeks). HPV-16 correlated with low CD8 þ and high CD25 þ . None of the regressing CIN2-3 lesions contained HPV-16. The regressing CIN2-3 lesions had lower numbers of stromal CD138 þ and higher numbers of stromal CD8 þ cells; higher stromal and intra-epithelial ratios of CD4 þ /CD25 þ cells; higher ratios of CD8 þ /CD25 þ cells and lower ratios ofþ cells in the stroma. With multivariate survival analysis, stromal CD8 þ cell numbers, CD4 þ /CD25 þ cell ratios and CD138 þ cell numbers are found to be independent regression predictors. In conclusion, in non-HPV-16 CIN2-3 lesions, assessing stromal immune cells can be a useful prognostic indicator of regression or persistence.

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“…Alguns estudos demonstraram que a baixa expressão do p53 e do pRb na metade inferior do epitélio cervical está associada ao AIS (84) , enquanto que outros estudos mostram o aumento da expressão do p53 e do p16 no AIS e adenocarcinoma invasivo (85) .…”

Section: Hpv E Alterações Glandularesunclassified

Valor da captura híbrida para o papilomavírus humano (HPV) no seguimento de pacientes submetidos à conização do colo uterino devido a lesão intraepitelial de alto grau por cirurgia de alta frequência (CAF)

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Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ

Cited by 6 publications

References 22 publications

The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2–3

The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2–3

Local immune response in the microenvironment of CIN2–3 with and without spontaneous regression

Valor da captura híbrida para o papilomavírus humano (HPV) no seguimento de pacientes submetidos à conização do colo uterino devido a lesão intraepitelial de alto grau por cirurgia de alta frequência (CAF)

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