Low particle concentrations of nanoplastics impair the gut health of medaka

Zhou, Yinfeng; Liu, Gui; Wei, Wenbo; Xu, Elvis Genbo; Zhou, Wei; Sokolova, Inna M.; Li, Mingyou; Wang, Youji

doi:10.1016/j.aquatox.2023.106422

Cited by 23 publications

(4 citation statements)

References 79 publications

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“…In this study, the activities of lipase, trypsin and amylase in the intestine of M. albus decreased at different levels with exposure to higher levels of PS-NPs, indicating that the latter could negatively impact intestinal digestion and absorption of nutrients. 38…”

Section: Discussionmentioning

confidence: 99%

Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)

Zhou,

Liu

et al. 2024

Environ. Sci.: Nano

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Section: Discussionmentioning

confidence: 99%

Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)

Zhou,

Liu

et al. 2024

Environ. Sci.: Nano

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“…Further, medaka may produce abnormal satiety due to the ingestion of high concentrations of NPs [35]. The activity of AMS showed a significant decrease in all NPs-treated groups, which implies that NPs inhibit carbohydrate metabolism [36]. Similarly, a reduction in digestive enzyme activities was found in different organisms upon NP exposure, e.g., the juvenile guppy (Poecilia reticulata) [33], juvenile large yellow croaker (Larimichthys crocea) [2], juvenile orange-spotted groupers (Epinephelus coioides), and thick-shell mussels (Mytilus coruscus) [37].…”

Section: Effects Of Long-term Nanoplastics Exposure On Digestive Enzymesmentioning

confidence: 94%

Long-Term Exposure to Polystyrene Nanoplastics Impairs the Liver Health of Medaka

Zhou

Zhao

et al. 2022

Water

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Nanoplastic (NP) has become a global environmental concern due to its potentially wide distribution and unknown impacts on organisms. Many laboratory studies have reported the short-term toxicity of NPs but their long-term effects are unclear. Here, the chronic hepatoxic effects of NPs (diameter 100 nm; 0, 10, and 104 items/L) in medaka (Oryzias latipes) were evaluated after three-month exposure by investigating the alterations in enzymatic biomarkers (digestion, oxidative status, and immunity) and histopathology in the liver. The trypsin and chymotrypsin activities of digestive enzymes were induced at a low concentration of NPs (10 items/L) but inhibited at high concentration (104 items/L); only the amylase activity was significantly decreased in all NP-treated medaka. Oxidative stress was also induced by NP exposure, which was indicated by the responsive superoxide dismutase and catalase. Lysozyme was significantly reduced after exposure to a high concentration of NPs, while alkaline phosphatase was significantly induced at a low concentration. Exposure to NPs also caused liver damage (e.g., congestion and dilated sinusoids). Taken together, our findings show that chronic exposure to NPs at low particle concentrations can impair the liver health of medaka by affecting liver enzymatic functions and causing histological damage. This implies potentially long-term threats of NPs to aquatic organisms, which call for more long-term aquatic toxicological studies on various species using low environmental concentrations.

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“…It is well-documented that NPs have predominately accumulated in the aquatic organism’s intestinal tract, including zebrafish, rainbow trout (Oncorhynchus mykiss), sea urchins (Strongylocentrotus intermedius), and D. magna. − There is a growing number of studies that have associated NPs exposure with impaired intestinal health effects in fish . Tilapia (Oreochromis niloticus)-administered NPs induced epithelial damage in the intestine and impaired intestinal permeability, suggesting that ingested NPs can impair the physical barrier of the gut in fish .…”

Section: Introductionmentioning

confidence: 99%

“…19−22 There is a growing number of studies that have associated NPs exposure with impaired intestinal health effects in fish. 23 Tilapia (Oreochromis niloticus)-administered NPs induced epithelial damage in the intestine and impaired intestinal permeability, suggesting that ingested NPs can impair the physical barrier of the gut in fish. 24 Juvenile grouper (Epinephelus coioides) exposed to polystyrene NPs disrupted the intestinal microbial community and reduced the activity of digestive enzymes.…”

Section: Introductionmentioning

confidence: 99%

Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment

Wang,

Qiu,

Cheng

et al. 2023

ACS EST Water

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The global impact of nanoplastics (NPs) as emerging pollutants on water environments remains uncertain. Previous studies have focused on the toxicity of NPs itself, often ignoring the important effects of exposure routes. Here, we evaluated the impact of different exposure routes (waterborne, foodborne, and coexposure) of 80 nm polystyrene NPs on intestinal accumulation and inflammatory response using zebrafish. Our results demonstrated that aqueous and dietary exposures led to both time-and dose-dependent bioaccumulation of NPs, damaged intestinal structure, and induced immune cells and genes in the intestine. While waterborne exposure caused lower NPs accumulation than foodborne exposure, both demonstrated similar immunotoxicity in the intestine. In addition, co-exposure can lead to a higher accumulation of NPs and toxicity in zebrafish, suggesting that the risk of environmental exposure may be underestimated, as current toxicity assessments have focused on single-route exposure scenarios. We further revealed that NPs activated downstream genes of the toll-like 4 receptor, suggesting that NPs can cause an inflammatory response. Our study is the first known to report that exposure to NPs via different routes induces an accumulation in the intestine and can cause similar intestinal disturbance effects, providing new insights for adequately assessing the potential risks of NPs.

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Low particle concentrations of nanoplastics impair the gut health of medaka

Cited by 23 publications

References 79 publications

Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)

Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)

Long-Term Exposure to Polystyrene Nanoplastics Impairs the Liver Health of Medaka

Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment

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