Low plasma adiponectin concentration is an indicator of the metabolic syndrome

Santaniemi, Merja; Kesäniemi, Y. Antero; Ukkola, Olavi

doi:10.1530/eje.1.02287

Cited by 103 publications

(67 citation statements)

References 24 publications

(24 reference statements)

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“…Our results was also in agreement with Santaniemi et al, 26 as they found that in both the sexes, the plasma adiponectin levels were lower in subjects with MS when compared with subjects with no diagnosis of MS (P<0.001), and Plasma adiponectin levels did not differ between subjects with National Cholesterol Education Program (ATPIII) and International Diabetes Federationdefined MS. They concluded that lower adiponectin levels were associated with different components of the MS and there was a trend towards decreasing adiponectin levels with an increasing number of components of MS in both the sexes.…”

Section: Discussionsupporting

confidence: 93%

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Study of plasma adiponectin level in patients with metabolic syndrome

Ahmed

Mohamed

2015

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 93%

“…This correlation results was in agreement with Santaniemi et al, 26 as they found that adiponectin was correlated negatively with measures of body fat, fasting plasma glucose and triglycerides, and positively correlated with HDL-cholesterol.…”

Section: Discussionsupporting

confidence: 92%

Study of plasma adiponectin level in patients with metabolic syndrome

Ahmed

Mohamed

2015

Int J Res Med Sci

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“…38 Hypoadiponectinaemia is related to the development of insulin resistance. 7 Therefore, the effect of high adiponectin on SBP may be mediated through lowering of insulin resistance. However, the association between systolic ABP and low plasma adiponectin level remained significant after adjustment for the insulin sensitivity index, which is consistent with the concept that it is not dependent on the level of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…1 The association between a low plasma adiponectin level and an unfavourable metabolic and cardiovascular profile has been shown in several studies. [2][3][4][5][6][7][8][9][10][11][12] The adiponectin level is reduced in subjects with hypertension 9,11,12 and the reduced adiponectin level has been claimed to be an independent risk factor for hypertension in cross-sectional studies. 13 The biological mechanisms responsible for the association of the reduced adiponectin level with higher blood pressure are not known at present 5 and the specific biological role of adiponectin still awaits clarification.…”

Section: Introductionmentioning

confidence: 99%

Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

2009

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The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40-60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to Po0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P ¼ 0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system.

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“…Adiponectin is an adipocyte-derived plasma protein, which has roles in preventing the development of atherosclerosis and the impairment of glucose and lipid metabolisms (3). Adiponectin expression and secretion from white adipose tissue are regulated by various factors including obesity, insulin-resistant status, and also some genetic backgrounds (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels

Imamura

Takahashi²,

Murakami³

et al. 2008

European Journal of Endocrinology

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Objective: Genetic variants of the endothelial nitric oxide synthase (eNOS) gene, Glu298Asp and T-786C, have been reported to be associated with cardiovascular disease. Adiponectin is an adipocytederived plasma protein with insulin-sensitizing and vascular protective effects; its levels are typically low in metabolic syndrome. Therefore, eNOS gene polymorphisms may also be associated with specific metabolic profiles, including plasma adiponectin levels and atherogenic lipids. Methods: We evaluated the functional significance of eNOS gene Glu298Asp and T-786C polymorphisms on endothelial function and metabolic profiles in 101 healthy young men (mean age 30.3 years) before the progression of atherosclerotic lesions. Results: No linkage disequilibrium was found between the two genotypes. The Asp298 allele carriers of the eNOS gene presented significantly higher plasma low density lipoprotein (LDL) cholesterol, LDL particle size, malondialdehyde-modified LDL (MDA-LDL), and fasting insulin levels and lower plasma high density lipoprotein (HDL) cholesterol, apolipoprotein A-I levels, and endothelium-dependent vasodilation when compared with noncarriers. In spite of higher MDA-LDL levels, Asp298 carriers had significantly larger LDL particle size. By contrast, in C-786 allele carriers, systolic blood pressure was significantly higher, and plasma high-molecular-weight adiponectin levels and endotheliumdependent vasodilation were significantly lower than those in non-carriers. Conclusions: Although both eNOS polymorphisms induced endothelial dysfunction, the eNOS T-786C polymorphism may be associated with adiponectin levels, whereas the Glu298Asp polymorphism may be associated with atherogenic lipid levels.

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Low plasma adiponectin concentration is an indicator of the metabolic syndrome

Cited by 103 publications

References 24 publications

Study of plasma adiponectin level in patients with metabolic syndrome

Study of plasma adiponectin level in patients with metabolic syndrome

Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels

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