Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck

Abstract

Angiosarcoma of the head and neck (ASHN) is one of the most aggressive malignancies of the skin, but the prognostic factors are not well known because of its rarity. Recently, high plasma fibrinogen levels were reported to predict poor prognosis in several malignancies. In the present retrospective study, we suggest that low plasma fibrinogen levels predict poor prognosis for ASHN.

Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review

“…A previous retrospective study suggested that patients with angiosarcoma with elevated ferritin levels had a significantly poorer overall survival in comparison with patients with normal ferritin levels ( 18 ). Additionally, the patient in the present study exhibited a significant decrease in fibrinogen, which aligns with reports in the literature indicating that patients with angiosarcoma have a higher risk of bleeding, and low plasma fibrinogen levels are predictive markers of a poor prognosis ( 19 , 20 ). In the case reported in the present study, it was hypothesized that excess splenic hemorrhage resulted in substantial fibrinogen consumption, with a subsequent marked reduction in fibrinogen levels.…”

Fibrinogen and tumors

“…However, insights from Nenclares' research on oral squamous cell carcinoma (OSCC) patients suggest that Fg levels lack predictive value in this context (52). Additionally, it is noteworthy that decreased plasma Fg levels are indicative of poor prognosis in angiosarcoma of the head and neck (ASHN) (53) and acute promyelocytic leukemia (APL) (54), as reported in the literature.…”