Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Lauretani, Fulvio; Semba, Richard D.; Bandinelli, Stefania; Ray, Amanda L.; Ruggiero, Carmelinda; Cherubini, Antonio; Guralnik, Jack M.; Ferrucci, Luigi

doi:10.1007/bf03324762

Cited by 34 publications

(27 citation statements)

References 26 publications

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“…And this despite findings in France and Italy (with similar Se levels to those in the UK) that low blood Se in people over 65 years is a strong predictor of mortality in the ensuing 6-9 years (Akbaraly et al 2005;Lauretani et al 2008).…”

contrasting

confidence: 52%

Selenium in cereals: improving the efficiency of agronomic biofortification in the UK

Lyons

2010

Plant Soil

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Wheat, despite its relatively low selenium (Se) concentration in the UK, is still an important dietary Se source and its biofortification by use of Se fertiliser may be an efficient means to increase the relatively low Se status of the population. We need to know more about the fate of Se applied to the soil and how to ensure the efficiency of Se application, and the three studies reported in this issue of Plant and Soil are timely and informative. Selenium in soil, both globally and locally, is notoriously variable; however, the soils in these studies yielded wheat grain Se concentrations in the narrow range of 16-44 ng/g. The low plant Se levels reported here are not surprising, given that selenite is the dominant Se form in these soils. A regression equation (which used total and extractable Se and extractable S as variables) explained a high proportion of the variance in grain Se concentration. Sulphur application (a common practice on UK wheat growing soils) had variable effects on grain Se concentration, depending on soil S status, pH and possibly other factors. A fertiliser methodology study investigated ways to optimise Se application for the purpose of biofortification. It was calculated that an application of a modest 10 g Se/ha as selenate would increase the grain Se concentration of UK wheat from around 30 ng/g to 300 ng/g. The national Se fertiliser program in Finland shows that this increase would have a large effect on population Se status. However, Se recovery in grain at this application rate is only 14%, and it can be argued that large-scale agronomic biofortification of cereals with Se would be somewhat wasteful of a relatively scarce trace element. Selenium's effects and interactions in soil, plants, animals and humans are complex and often surprising and will keep researchers busy well into the future.

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confidence: 52%

Selenium in cereals: improving the efficiency of agronomic biofortification in the UK

Lyons

2010

Plant Soil

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“…16 Low serum selenium concentrations were independent predictors of mortality among older community-dwelling adults in France, 17 the United States, 13 and Italy. 18 …”

Section: Discussionmentioning

confidence: 99%

Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I

et al. 2010

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Background & Aims Red cell distribution width (RDW), a measure of heterogeneity in the size of circulating erythrocytes, is associated with some chronic diseases and predicts mortality. Although oxidative damage and inflammation have been theorized to affect RDW, the relationships of antioxidants and inflammation with RDW have not been well characterized. The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time. Methods RDW was measured at baseline, 12 months, and 24 months follow-up in 786 moderately to severely disabled community-dwelling women, aged ≥65 years, in the Women’s Health and Aging Study I in Baltimore, Maryland. Results Selenium was significantly associated with RDW at baseline and predicted RDW over two years’ follow-up in separate multivariate mixed effects models that adjusted for other covariates. As expected, the addition of IL-6 to the models attenuated the association of serum selenium with RDW, as low antioxidant levels are known to upregulate IL-6. Total carotenoids were associated with RDW at baseline and one year follow-up. Protein carbonyls and α-tocopherol were not significantly associated with RDW. Conclusion Serum selenium is an independent predictor of RDW and may potentially mediate effects on RDW through IL-6.

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“…Different finding shown in EVA study, indicating that the mean of plasma selenium level for the elderly with the mean age of 54 years old was 100.2 µg/L. 3,8 The lower plasma selenium level in this study could be caused by several factors. The possibility of source of selenium in the Indonesian food was lower compared to other countries.…”

Section: Resultsmentioning

confidence: 82%

“…9 Lauretani et al stated that selenium has an important role in proinflammatory condition by its function on glutation peroxidase enzyme to break down hidrogen peroxidase and lipid peroxodase so the stress oxidative can be reduced. 3 The assessment of selenium level in this study has been done by measuring SELENBP1 level. Based on Yang et al, selenium has three forms of protein categories, which are protein containing selenomethionine, protein containing selenocysteine, and peptide which bounded selenium such SELENBP1.…”

Section: Resultsmentioning

confidence: 99%

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Plasma Selenium Level based on Dietary Intake in Geriatric Clinic Population at Dr. Hasan Sadikin General Hospital, Bandung

Silviana¹,

Yasmin²,

Lesmana³

2016

PCPR

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Low plasma selenium level was associated with the increasing risk of death in geriatric patients, particularly those with multiple comorbidities. The sufficient level of selenium intake as an antioxidant is necessary for this population. This study aimed to investigate the plasma selenium level based on dietary intake in geriatric clinic population at Dr. Hasan Sadikin General Hospital Bandung.This study was a descriptive study using cross-sectional method. Fourteen geriatric patients were selected by consecutive sampling technique. Semiquantitative food frequency questionnaire (SQ-FFQ) was used as a tool to assess dietary intake. Plasma selenium level was measured as selenium binding protein 1 (SELENBP1) using enzyme-linked immunosorbent assay kit. Overall, mean of plasma selenium level of the subjects was 2,68 µg/L and mean of selenium intake was 62,85 µg/day. Selenium level of the subjects with sufficient selenium intake (85,7%) was 2,62 µg/L and selenium level of the subjects with deficient selenium intake (14,3%) was 3,05 µg/L. In conclusion, plasma selenium level among geriatric patients was varied and not dependent on dietary intake.

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Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Cited by 34 publications

References 26 publications

Selenium in cereals: improving the efficiency of agronomic biofortification in the UK

Selenium in cereals: improving the efficiency of agronomic biofortification in the UK

Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I

Plasma Selenium Level based on Dietary Intake in Geriatric Clinic Population at Dr. Hasan Sadikin General Hospital, Bandung

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