The scarcity of water is perceived as a systematic global risk due to increasing water demand. Vertical flow constructed wetland (VFCW) is proposed as an energetically efficient and economical process to treat greywater (GW) for non‐potable purposes. Macrophyte contributes a significant amount to the treatment process, and it depends on species, and their ecology. In this study, four single‐stage VFCW systems were planted with locally available plant species named Hymenocallis littoralis as Plant 1, Phragmites australis as Plant 2, Canna indica Plant as 3, and Colocasia as Plant 4, which were used for the treatment of GW. The mean removal efficiencies associated with Plant 1, Plant 2, Plant 3, and Plant 4 are 55.13%, 48.11%, 52.53%, and 56.39% for chemical oxygen demand (COD); 45.35%, 35.36%, 64.10%, and 56.39% for ammonia; and 32.97%, 20.85%, 71.57%, and 33.40% for phosphate, respectively. All systems show significant removal efficiency (more than 40%) of all pollutants, except TDS and pH. Among all the observed plants, C. indica achieved the highest removal efficiency for COD, ammonia, and phosphate. The obtained results were analyzed for the dependency of correlations with effluent, influent, and macrophytes used in the treatment system. The principal component analysis (PCA) identified two principal components from 13 variables and explained 50.25%, 47.47%, and 45.62% variance of normalized datasets in VFCW. The PCA also shows significant correlations of plant species with different targeted effluent parameters.