Low-Power Wireless Micromanometer System for Acute and Chronic Bladder-Pressure Monitoring

Majerus, Steve; Fletter, Paul C.; Damaser, Margot S.; Garverick, S.L.

doi:10.1109/tbme.2010.2085002

Cited by 75 publications

(48 citation statements)

References 11 publications

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“…For this reason, using of flexible sensors, [15][16][17][18][19][20][21][22][23][24][25][26] that could be fixed on the surface of bladder or inside the vest, may provide the information on the bladder filling status without the need of making an incision in the bladder wall. [44,45] In our study, we used a commercial FlexiForce force sensor (South Boston, MA) to accurately quantify the effect of bladder filling on the resistance change of the sensor. More information on the sensor is provided in the Experimental Section.…”

Section: Integration Of the Actuating Device With A Force Sensormentioning

confidence: 99%

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Hassani

Gammad

Mogan

et al. 2017

Adv Materials Technologies

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for such transformation. [3] Voluntary repeatable shape transformation, material biocompatibility, and small weight of NiTi shape memory alloy (SMA) actuators make them suitable for medical applications. [4][5][6][7][8][9][10][11][12] Usage of NiTi SMA actuators for muscular contraction, [8] artificial anal sphincter, [7] urethral valve, [13] myocardium, [8] drug delivery system, [3] and most recently, voiding of a bladder, [14] has been reported.The previous SMA-based actuator for voiding of a bladder consisted of a flexible vest that covered the bladder surface and physically contracted it upon the actuation of assembled SMA wires. [14] Since a fixed length was considered for SMA wires in this design, the device could be used for only one bladder size that was matched with the total inner diameter of actuator. The proposed design in our study has a more conformable vest that can be fitted for a wider range of bladder sizes in rats with similar body weight, and can substantially improve the voiding volume and energy consumption of the device.The previous SMA-based actuator was proposed for assisting the detrusor muscle in myogenic underactive bladder (UAB) patient with detrusor muscle contractility disorder but intact nerves. [14] Our study broadens the application of the actuating device also to neurogenic UAB patients suffering from both damaged detrusor muscle and nervous system; these patients are not able to rely on the natural nerve pathways to realize The use of shape memory alloy (SMA) actuators to restore voiding of bladder for myogenic under active bladder (UAB) patients is proposed recently. Even though previous work show the unique capability of this technology for bladder voiding, the low voiding volume and high energy consumption of the device limit the advancement of this technique. This study proposes a novel approach using an interlaced configuration to overcome these limitations. In this device, SMA actuators are threaded through rigid anchor points of the flexible vest. The novel anchorage of SMA actuators provides more conformability for the vest and lower energy consumption for the device, while the new interlaced configuration enhances the voiding volume. The device is tested initially on a rubber model for the bladder, then it is implanted in an anesthetized rat, and a voiding volume of more than 20% at 4 V is successfully achieved. A commercial force sensor is integrated with the device to make it suitable for neurogenic UAB patients. The sensor provides a feedback control signal to the patient to initiate the actuation of the device upon fullness of bladder. The overall system is a promising advance over the state-of-the-art providing bladder voiding in UAB patients.

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Section: Integration Of the Actuating Device With A Force Sensormentioning

confidence: 99%

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Hassani

Gammad

Mogan

et al. 2017

Adv Materials Technologies

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“…In Majerus et al [40], a bladder-pressure-sensing implantable for chronic patients is introduced, based on a specific ASIC design, and also based on a RF powering (LC coupling at 3-MHz), and telemetry solution, but operating in an unlicensed ISM band (27.12-MHz), and a rechargeable battery solution. In this case, the size is also based on medical constraints given by minimally invasive cystoscopic surgery, defining a final capsule of 7-mm wide by 4-mm thick by 15-mm long.…”

Section: Description and Challenges Of A Customized Biomedical Implanmentioning

confidence: 99%

Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics

Juanola-Feliu

Miribel-Català

Avilés

et al. 2014

Sensors

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The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device.

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“…Consequently, closed-loop feedback system with the ability to monitor the bladder volume and to trigger stimulation is needed. Currently known methods of monitoring the bladder volume change include ultrasound devices, pressure sensors located in the bladder wall [12], [13], body impedance measurement [14], recording electromyogram (EMG) of external urethral sphincter [15], and tracing the bladders activities through its neural pathway [1], [7], [11], [16]. Each one of these techniques has its drawbacks, such as artifacts caused by movements impacting the sensors, electrodes migration and irritation to bladder.…”

Section: Introductionmentioning

confidence: 99%

An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration

Wang

Zhang

Liu

et al. 2014

IEICE Trans. Inf. & Syst.

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SUMMARYThis paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusorsphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 μV rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analogto-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (±0.9 V to ±12.5 V) and variable output current amplitude (0-500 μA) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots. key words: neural prosthesis, functional electrical stimulation,closed-loop bladder control, acute animal experiment, spinal cord injury

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Low-Power Wireless Micromanometer System for Acute and Chronic Bladder-Pressure Monitoring

Cited by 75 publications

References 11 publications

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics

An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration

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