Low pressure plasma treatment of poly(3‐hydroxybutyrate): Toward tailored polymer surfaces for tissue engineering scaffolds

Nitschke, Mirko; Schmack, G.; Janke, Andreas; Simon, Frank; Pleul, Dieter; Werner, Carsten

doi:10.1002/jbm.1274

Cited by 114 publications

(54 citation statements)

References 35 publications

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“…It therefore does not usually affect the scaffold structure and mechanical properties significantly. Nitschke et al utilized low pressure ammonia plasma treatment for the modification of poly(3-hydroxybutyrate) (PHB) thin films [115]. The introduction of amine function was used for subsequent protein immobilization.…”

Section: Surface Modificationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Section: Surface Modificationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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“…Diese Modelloberflächen wurden einer NH 3 -Plasmabehandlung unterzogen [4]. Weitere Einsatzmöglichkeiten von resorbierbaren PatchImplantaten bestehen in der in vitro-Kopplung von Knochenzellen oder epithelialem Gewebe, zur Abdeckung von Wundflächen, ohne dass ein Dichtungseffekt erforderlich wäre.…”

Section: Plasmabehandlungunclassified

Implantat auf Basis von Poly(3-hydroxybuttersäure)

Schmack¹,

Gliesche²,

Nitschke³

et al. 2002

BIOmaterialien

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“…Radio-frequency (RF) plasma is usually used to treat the surface of different polymers [14,15]. Reactive gases allowus to obtain the necessary functional groups on the P3HB surface and also impart other properties, such as bioactivity [16][17][18][19]. The data on the influence of the different working parameters of plasma, such as the type of gas, power, or pressure, on the changes in the properties of PHA, particularly hydrophilicity, is limited.…”

Section: Introductionmentioning

confidence: 99%

Surface wettability and energy effects on the biological performance of poly-3-hydroxybutyrate films treated with RF plasma

Syromotina

Surmenev

Boyandin

et al. 2016

Materials Science and Engineering: C

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АbstractThe surface properties of poly-3-hydroxybutyrate (P3HB) membranes were modified using oxygen and an ammonia radio-frequency (RF, 13.56 MHz) plasma. The plasma treatment procedures used in the study only affected the surface properties, including surface topography, without inducing any significant changes in the crystalline structure of the polymer,with the exception being a power level of 250W. Thewettability of themodified P3HB surfaces was significantly increased after the plasma treatment, irrespective of the treatment procedure used. Itwas revealed that both surface chemistry and surface roughness changes caused by the plasma treatment affected surface wettability. A treatment-induced surface aging effect was observed and resulted in an increase in the water contact angle and a decrease in the surface free energy. However, the difference in the water contact angle between the polymers that had been treated for 4 weeks and the untreated polymer surfaces was still significant. A dependence between cell adhesion and proliferation and the polar component of the surface energy was revealed. The increase in the polar component after the ammonia plasma modification significantly increased cell adhesion and proliferation on biodegradable polymer surfaces compared to the untreated P3HB and the P3HB modified using an oxygen plasma.

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Low pressure plasma treatment of poly(3‐hydroxybutyrate): Toward tailored polymer surfaces for tissue engineering scaffolds

Cited by 114 publications

References 35 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

Implantat auf Basis von Poly(3-hydroxybuttersäure)

Surface wettability and energy effects on the biological performance of poly-3-hydroxybutyrate films treated with RF plasma

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