Low prevalence of hearing impairment among very low birthweight infants as detected by universal neonatal hearing screening

Roth, Daphne Ari‐Even; Hildesheimer, Minka; Maayan-Metzger, Ayala; Muchnik, Chava; Hamburger, A; Mazkeret, R; Kuint, Jacob

doi:10.1136/adc.2005.074476

Cited by 45 publications

(12 citation statements)

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“…Although we screened more than 7000 preterm infants, the total number of m.1555A>G carriers in our study was low, which limits the statistical power of our observation. The rate of failed hearing screening in our cohort was 11%, which is close to reported data in the literature [ 14 ]. It is important to note, that most infants with failed newborn hearing screening do not develop permanent hearing loss.…”

Section: Discussionsupporting

confidence: 89%

Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants

et al. 2014

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BackgroundThe mitochondrial m.1555A>G mutation is associated with a high rate of permanent hearing loss, if aminoglycosides are given. Preterm infants have an increased risk of permanent hearing loss and are frequently treated with aminoglycoside antibiotics.MethodsWe genotyped preterm infants with a birth weight below 1500 grams who were prospectively enrolled in a large cohort study for the m.1555A>G mutation. Treatment with aminoglycoside antibiotics in combination with mitochondrial m.1555A>G mutation was tested as a predictor for failed hearing screening at discharge in a multivariate logistic regression analysis.Results7056 infants were genotyped and analysed. Low birth weight was the most significant predictor of failed hearing screening (p = 7.3 × 10-10). 12 infants (0.2%) had the m.1555A>G-mutation. In a multivariable logistic regression analysis, the combination of aminoglycoside treatment with m.1555A>G-carrier status was associated with failed hearing screening (p = 0.0058). However, only 3 out of 10 preterm m.1555A>G-carriers who were exposed to aminoglycosides failed hearing screening. The m.1555A>G-mutation was detected in all mothers of m.1555A>G-positive children, but in none of 2993 maternal DNA-samples of m.1555A>G-negative infants.ConclusionAntenatal screening for the m.1555A>G mutation by maternal genotyping of pregnant women with preterm labour might be a reasonable approach to identify infants who are at increased risk for permanent hearing loss. Additional studies are needed to estimate the relevance of cofactors like aminoglycoside plasma levels and birth weight and the amount of preterm m.1555A>G-carriers with permanent hearing loss.

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Section: Discussionsupporting

confidence: 89%

Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants

et al. 2014

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“…31 The OAE hearing screening test fail rate was 7.8% in the healthy control group and 12.4% for the VLBW children. On follow-up ABR testing several weeks after discharge, only 3% of the VLBW patients were found to have hearing loss.…”

Section: Epidemiology Of Neonatal Hearing Lossmentioning

confidence: 88%

Hearing loss in children with very low birth weight: current review of epidemiology and pathophysiology

Cristóbal

Oghalai

2008

Archives of Disease in Childhood - Fetal and Neonatal Edition

161

129

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An association between birth weight <1500 g (very low birth weight (VLBW)) and hearing loss has been long recognised. As universal hearing screening programmes have become widely implemented and the survival rate of VLBW babies in modern intensive care units has increased, we have gained a substantially better understanding of the nature of this problem. However, many gaps in our knowledge base exist. This review describes recent data on hearing loss in the VLBW population and explains the current level of understanding about the physiological basis underlying the auditory deficits in these patients. Although VLBW alone may not have a severe impact on hearing, it is commonly associated with multiple other risk factors that can alter hearing in a synergistic fashion. Therefore, the risk of hearing loss is substantially higher than in the general newborn population. Also, it is important to perform a more comprehensive audiometric evaluation than standard otoacoustic emission screening for infants who are in the neonatal intensive care unit in order not to miss hearing loss due to retrocochlear pathology. Furthermore, children with VLBW are also at increased risk of experiencing progressive or delayed-onset hearing loss, and thus should continue to have serial hearing evaluations after discharge from the neonatal intensive care unit.

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“…Another study evaluated the prevalence of hearing impairment in a cohort of 337 VLBW infants who were cared for in the NICU and survived to discharge, as well as 1205 healthy newborns. 23 The OAE hearing screening test fail rate was 7.8% in the healthy control group and 12.4% for the VLBW children. On follow-up ABR testing several weeks after discharge, only 3% of the VLBW patients were found to have hearing loss.…”

Section: Resultsmentioning

confidence: 88%

Targeted hearing screening in newborns

Mehar¹,

Somani²,

Singh

et al. 2016

Int J Contemp Pediatr

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Background: Hearing is important for learning to talk. Without speech and hearing it is difficult for interpersonal relationships to develop and thrive The aim of this study was to screen high risk newborn for hearing loss by TEOAE and ABER technique and to find out the risk factor associated with hearing loss in newborn infants. Methods: A total of 103 high risk neonates were randomly selected from NICU of this hospital after clinical stabilization. Transiently evoked otoacoustic emissions were performed in all the neonates. Neonates who passed transiently evoked otoacoustic emissions test were subjected to Auditory Brainstem Evoked Response (ABER) test for confirming hearing loss. Results: Hearing assessment done in all 103 patients and a total of 8 neonates were found to have hearing abnormalities, out of these 8 new-borns 5 had conductive hearing loss and 3 had sensorineural hearing loss. Low Birth weight and ventilator support were observed significantly associated with occurrence of hearing loss. No significant association of hearing loss was observed with gestational age, sex, infection, and associated diseases. Conclusions: Low Birth weight and mechanical ventilator were significantly associated with hearing loss.

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Low prevalence of hearing impairment among very low birthweight infants as detected by universal neonatal hearing screening

Abstract: The study shows a low incidence of sensory-neural hearing loss in a cohort of VLBW infants and a relatively high incidence of conductive hearing loss. TEOAE screening was found to be an effective first stage in-hospital hearing screening tool in this population.

Cited by 45 publications

References 44 publications

Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants

Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants

Hearing loss in children with very low birth weight: current review of epidemiology and pathophysiology

Targeted hearing screening in newborns

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