Low prevalence of hepatitis C virus infection in Greek diabetic patients

Sotiropoulos, Alexios; Peppas, Theodoros; Skliros, E.; Apostolou, Ourania; Kotsini, V; Pappas, Stefanos

doi:10.1046/j.1464-5491.1999.00009.x

Cited by 49 publications

(54 citation statements)

References 9 publications

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“…The present study was not able to reveal a difference in the frequency of infection by HCV between diabetics and non-diabetics, which is in agreement with the studies by Mangia et al [7], Sotiropoulos et al [8], Virseda et al [9] and Wolff et al [10]. On the other hand, this feature is in disagreement with the studies that found a higher prevalence of HCV infection in type 2 diabetic patients [2,[4][5][6].…”

Section: Hepatitis C Infection In Diabetic Patientscontrasting

confidence: 56%

“…In order to justify screening for HCV in diabetics patients other indicative features for this infection should be considered, such as altered levels of aminotransferases or other signs of liver disease [8,15].…”

Section: Hepatitis C Infection In Diabetic Patientsmentioning

confidence: 99%

“…Although there are evidences that diabetes is more common among patients infected with HCV, cross-sectional studies have shown conflicting results when the frequency of HCV infection is analyzed in type 2 diabetes patients. Some studies have found that HCV was more common in diabetics than in general population [4][5][6], while others have not confirmed this finding [7][8][9][10].…”

mentioning

confidence: 99%

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Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil

Costa¹,

Mussi²,

Brianeze³

et al. 2008

Braz J Infect Dis

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In order to assess the importance of HCV infection as a possible risk factor for type 2 diabetes mellitus, a casecontrol study was conducted, comparing the prevalence of HCV infection among diabetic and non-diabetic patients. Diabetic outpatients attending to a University Hospital in Central-West Brazil were evaluated between April and October 2005. A control group composed by patients from the same institution was matched by gender and age. Candidates to control group were included only if fasting glucose measures were under 100 mg/dL. Diabetics and controls had blood samples taken in order to test for antibodies against HCV (anti-HCV) by enzyme-immunoassay. Polymerase chain reaction and immunoblot were performed to confirm the anti-HCV status. Each group included 206 participants. Despite of the groups were in general comparable. The diabetics had a greater body mass average and smaller family income. The prevalence of confirmed anti-HCV in the diabetic group was of 1.4%, which was similar to the controls (1%). Finding statistical difference may have been hampered by the low frequency of HCV infection in both groups. It was not possible to demonstrate a role of HCV as an etiologic factor in type 2 diabetes, since HCV infected patients represented a small portion of the overall diabetes cases. This finding does not allow to recommend regular screening for HCV infection in type 2 diabetics in this region.

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Section: Hepatitis C Infection In Diabetic Patientscontrasting

confidence: 56%

Section: Hepatitis C Infection In Diabetic Patientsmentioning

confidence: 99%

mentioning

confidence: 99%

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Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil

Costa¹,

Mussi²,

Brianeze³

et al. 2008

Braz J Infect Dis

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“…Certain negative data that are not in agreement with an association between HCV infection and T2DM have also been reported [97][98][99][100][101][102][103][104] . However, the number of published epidemiological studies that are in agreement with the association between HCV infection and T2DM is higher than the number of studies in disagreement with this hypothesis.…”

Section: Development Of T2dmmentioning

confidence: 99%

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Antonelli

Ferrari

Giuggioli

et al. 2014

WJD

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cytokines, chemokines, and other immune-mediated mechanisms. Few data have been reported on the association of CHC and T1DM and reports on the potential association between T1DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoimmunity and in certain cases lead to the development of T1DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with non-diabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effective programmes for the surveillance and treatment of diabetic CHC patients. AbstractHepatitis C virus (HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus (T1DM) and T2DM. T2DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2DM and chronic hepatitis C (CHC) infection. The processes through which CHC is associated with T2DM seem to involve direct viral effects, insulin resistance, proinflammatory Submit a

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“…It is now clear that hepatitis C conveys a risk for developing DM, in particular type 2 [5][6][7] . Moreover, several studies have found a high prevalence of anti-HCV antibodies among patients with diabetes, especially those with type 2 DM [8][9][10][11][12][13] ; however, some authors have not observed an association between HCV infection and diabetes [14][15][16] . Since effective therapy has become available for HCV, it may be worthwhile to determine virus prevalence in patients with and without diabetes, in order to decide whether a programme for screening should also focus on type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Association of hepatitis C virus infection and diabetes in central Tunisia

Kaabia¹,

Jazia²,

Slim³

et al. 2009

WJG

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AIM:To investigate hepatitis C virus (HCV) seropreva lence in Tunisian patients with diabetes mellitus and in a control group. METHODS:A crosssectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes (452 male, 817 female) and 1315 non diabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourthgeneration enzyme immunoassay. RESULTS:In the diabetic group, 17 (1.3%) were found to be HCVinfected compared with eight (0.6%) in the control group, although the difference was not significant (P = 0.057). Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype 1b in all cases. CONCLUSION:Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.

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Low prevalence of hepatitis C virus infection in Greek diabetic patients

Cited by 49 publications

References 9 publications

Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil

Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Association of hepatitis C virus infection and diabetes in central Tunisia

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