Low prevalence of hepatitis C infection among HIV-infected individuals in Slovenia: a nationwide study, 1985–2013

Seme, Katja; Škamperle, Mateja; Lunar, Maja M.; Vodičar, Polona Maver; Tomažič, Janez; Vidmar, Ludvik; Karner, Primož; Vovko, Tomaž; Pečavar, Blaž; Matičič, Mojca; Poljak, Mario

doi:10.1186/1471-2334-14-s4-o15

Cited by 7 publications

(8 citation statements)

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“…The study performed in 2002 demonstrated a low prevalence (14.5%) of HCV infection among Slovenian HIV-infected individuals (8). In a follow-up study performed on 87% of the entire population of Slovenian HIV-infected individuals identified by the end of 2008, the prevalence of HCV infection decreased to 10.7% (9). In the present study, which included 90.6% of the entire population of Slovenian HIV-infected individuals identified by the end of 2013, a further decrease in the prevalence of HCV infection was observed and reached only 7.6%.…”

Section: Resultscontrasting

confidence: 46%

“…The burden of HIV among MSM in Slovenia is disproportionately high and increasing quickly, whereas it is very low among IVDU (7). In our previous nationwide studies published in 2002 and 2009, we found a very low prevalence of HCV infection among Slovenian HIV-infected individuals (14.5% and 10.7%, respectively) (8,9). Because several developed countries have recently faced a dramatic increase in the incidence of acute hepatitis C among HIVinfected MSM (10-12), here we have updated the HCV infection prevalence data in Slovenian HIV-infected individuals.…”

Section: Introductionmentioning

confidence: 79%

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Prevalence, genotype distribution, and risk factors for hepatitis C infection among HIV-infected individuals in Slovenia: a 1986–2013 update

Škamperle

Seme

Lunar

et al. 2014

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Since the introduction of highly active antiretroviral therapy, chronic hepatitis C has become one of the leading causes of non-AIDS-related morbidity and mortality in patients with HIV infection. Two previous Slovenian nationwide studies published in 2002 and 2009 showed a very low prevalence of hepatitis C virus (HCV) infection among Slovenian HIV-infected individuals (14.5% and 10.7%, respectively). Methods and results: The presence of HCV infection was tested in 579/639 (90.6%) patients that were confirmed as HIV-positive in Slovenia by the end of 2013. Among them, 7.6% (44/579) of HIV-infected individuals were anti-HCV-positive, and 33/44 (75%) anti-HCV-positive patients were also HCV RNA-positive. HCV genotype 1 was most prevalent among HIV-infected patients (68%), followed by genotype 3 (20%), genotype 4 (8%), and genotype 2 (4%). Anti-HCV positivity was significantly higher in those that acquired HIV by the parenteral route (91.8%) than in those that acquired HIV by the sexual route (2.8%). Discussion: Slovenia remains among the countries with the lowest prevalence of HCV infection in HIV-infected individuals. Because the burden of HIV among men who have sex with men in Slovenia is disproportionately high and increasing rapidly, the current favorable situation could change quickly and should be therefore monitored regularly.

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Section: Resultscontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 79%

Prevalence, genotype distribution, and risk factors for hepatitis C infection among HIV-infected individuals in Slovenia: a 1986–2013 update

Škamperle

Seme

Lunar

et al. 2014

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Due to under-ascertainment and under-reporting, Slovenian HCV surveillance data, which are based on mandatory reporting of new hepatitis C diagnoses, do not provide a full picture of the epidemiology of HCV infection [15]. In Slovenia, we have some anti-HCV prevalence estimates for groups at higher risk (haemodialysis patients, people who inject drugs, HIV infected individuals) and data about the distribution of HCV genotypes among patients with HCV infection [16][17][18][19][20]. During the period from 2009 to 2013, the prevalence of anti-HCV among confidentially tested people who inject drugs entering or re-entering treatment within the network of Centres for the Prevention and Treatment of Illicit Drug Addiction ranged from the lowest 21.5% in 2010 to the highest 31.3% in 2013.…”

Section: Research Articlesmentioning

confidence: 99%

Hepatitis C virus infection among pregnant women in Slovenia: study on 31,849 samples obtained in four screening rounds during 1999, 2003, 2009 and 2013

et al. 2015

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“… 1 Though the development of virucidal methods and their application to clotting factor concentrates has eliminated the risk of transfusion of blood-borne infections by plasma products, 2 the risk still remains in developing countries where there is no ready access to these concentrates except in a few places. The prevalence of HCV varies in hemophiliacs among different countries from 15% 3 up to 71%. 4 However, HIV infection is considerably less, though it does exist and depends largely on the source of the plasma.…”

mentioning

confidence: 99%

Prevalence of hepatitis C virus infection and human immunodeficiency virus in a cohort of Egyptian hemophiliac children

Abdelwahab

El-Raziky

Kaddah

et al. 2012

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVEThe risk of blood-borne infections, especially hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection still remains in developing countries among children receiving blood products as hemophiliacs, but the risk is not known in Egypt. The objective of this study was to detect the prevalence of HCV and HIV infection among hemophiliac children to know the magnitude of the problem and determine potential risk factors.PATIENTS AND METHODSThis was a cross-sectional study conducted on 100 hemophiliac children that assessed the liver clinically and by laboratory tests. All children were screened for HCV and HIV antibodies by enzyme-linked immunosorbent assay. Those with positive HCV antibody titre were tested by polymerase chain reaction (HCV-PCR).RESULTSForty were positive for HCV antibodies with 19 children (47.5%) HCV-PCR positive as well. The mean age, average frequency of bleeds/year, dose of replacement therapy/year and alanine aminotransferase (ALT) levels were significantly high in HCV-antibody and PCR positive patients as compared to HCV antibody and PCR negative ones. None of our patients had clinical evidence of hepatic involvement or was co-infected with HIV.CONCLUSIONHIV infection does not appear to be a current health problem in Egyptian hemophiliac children though the prevalence of HCV infection is still high.

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Low prevalence of hepatitis C infection among HIV-infected individuals in Slovenia: a nationwide study, 1985–2013

Cited by 7 publications

References 0 publications

Prevalence, genotype distribution, and risk factors for hepatitis C infection among HIV-infected individuals in Slovenia: a 1986–2013 update

Prevalence, genotype distribution, and risk factors for hepatitis C infection among HIV-infected individuals in Slovenia: a 1986–2013 update

Hepatitis C virus infection among pregnant women in Slovenia: study on 31,849 samples obtained in four screening rounds during 1999, 2003, 2009 and 2013

Prevalence of hepatitis C virus infection and human immunodeficiency virus in a cohort of Egyptian hemophiliac children

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