Low prevalence of high risk human papillomavirus in normal oral mucosa by hybrid capture 2

González-Losa, Marı́a del Refugio; Manzano-Cabrera, Luis; Rueda-Gordillo, Florencio; Hernández-Solís, Sandra E.; Puerto-Solı́s, Marylı́n

doi:10.1590/s1517-83822008000100008

Cited by 10 publications

(15 citation statements)

References 12 publications

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“…With respect to the other genotypes, the most frequent was the low risk HPV6, identified by sequencing, which was identified in 6 women. High risk genotypes (16, 58, 59 and/or 18) were found in 1.8% of the study population which is lower than what has been reported by other authors ( Smith et al , 2004 ; Turner et al , 2011 ) but similar to our previous study of a group of odontology patients using High Risk Hybrid Capture 2 ( Gonzalez-Losa et al , 2008 ) and higher than a large study conducted in the USA by Gillison (2012) .…”

Section: Discussionsupporting

confidence: 73%

Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico

González-Losa¹,

Barrera²,

Herrera-Pech³

et al. 2015

Braz. J. Microbiol.

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High-risk human papillomaviruses (HR-HPV) are considered necessary for the development of cervical cancer. Furthermore, there is no doubt that some types of oral squamous cell carcinoma are associated with HR-HPV. The epidemiology of oral HPV infections in healthy subjects remains unclear due to a lack of knowledge. The objective of this study was to investigate the epidemiology of human papillomavirus infections of the oral mucosa without pathology. A cross-sectional study was performed; samples from 390 women seeking prenatal care, Pap smears, family planning or gynecological diseases were studied. Oral cells were collected by direct swab sampling. Information regarding sociodemographic status, sexual behavior, infectious diseases, contraceptive history and tobacco and alcohol consumption were obtained through direct interviews. HPV and genotypes were detected by type-specific polymerase chain reaction. Our results revealed that 14% of the women studied had an oral HPV infection. Women ≤ 20 years of age had the highest HPV prevalence (24.5%). In total, seven genotypes were identified, including the high-risk genotypes 16, 18, 58 and 59 and the low-risk genotypes 6, 81 and 13, the latter of which is a type exclusive to oral mucosa. Sexual behavior was not associated with the presence of genital HPV types in the oral mucosa. Genital HPV types were present in the oral mucosa of women without associated clinical manifestations; however, sexual behavior was not associated with infection, and therefore others routes of transmission should be explored.

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Section: Discussionsupporting

confidence: 73%

Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico

González-Losa¹,

Barrera²,

Herrera-Pech³

et al. 2015

Braz. J. Microbiol.

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“…We estimated the presence of HPV infection to be at least 20% in patient cases and less than 2% in control subjects. 7 , 8 The study was an unmatched design. The control-to-case ratio for each cancer site was 2:1.…”

Section: Methodsmentioning

confidence: 99%

Role of high-risk human papillomavirus in the etiology of oral and oropharyngeal cancers in Thailand: A case–control study

2018

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Background:Among developing countries, Thailand shows no increase in the incidence of human papillomavirus–driven oropharyngeal cancer. The causal role of human papillomavirus infection in this pathology has not been researched thoroughly.Methods:A hospital-based, case–control study was performed which included 104 patients with newly diagnosed oral and oropharyngeal squamous cell carcinomas and 104 individuals without cancer. The Cervista high-risk human papillomavirus and 16/18 assays were used to detect human papillomavirus. Odds ratios were used to assess the association between high-risk genotypes of human papillomavirus and the cancers.Results:High-risk human papillomavirus was detected in 4 of 52 (7.7%) oral cancer cases, 6 of 52 (11.5%) oropharyngeal cancer cases, and 1 of 104 (0.96%) control subjects. Of 104 cancer patients in the study, 83 were smokers. High-risk human papillomavirus was significantly associated with oropharyngeal cancer (odds ratio = 13.44, 95% confidence interval = 1.6–114.8) but was nonsignificantly associated with oral cancer (odds ratio = 8.58, 95% confidence interval = 0.9–78.9). However, after adjustment for smoking, high-risk human papillomavirus was determined to be nonsignificantly associated with oropharyngeal cancer (adjusted odds ratio = 5.83, 95% confidence interval = 0.8–43.5).Conclusion:Although low human papillomavirus prevalence was observed, the rate of high-risk human papillomavirus infection in the cancer group was still higher than that in the control group. Smoking may have an influence on the etiology of human papillomavirus–related cancers. However, the study is underpowered to clarify the role of human papillomavirus as the independent risk factor for oral and oropharyngeal cancers in the Thai population.

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“…It reported 65% of individuals to be positive for HPV16/18. [ 17 ] Western literature reports a low prevalence of HPV infection (<10%) in normal oral mucosa[ 18 19 20 21 22 ] There is not enough evidence to clearly establish the role of latent HPV infection of the oral cavity in normal individuals in the development of cancer. Western literature indicated an association between HR sexual behavior (oral sex and number of sexual partners) and HNSCC.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

Murthy

Calcuttawala

Chadha

et al. 2017

South Asian J Cancer

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Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35th Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India. All the ideas and facts were thereafter collated in this report. Various topics of controversy in dealing with the diagnosis and management of HPV-associated HNSCC have been highlighted in this report in context to the Indian scenario. Furthermore, the prevalence of the same and its association with tobacco and high-risk sexual behavior has been touched on. Conclusively, a set of recommendations has been proposed by the panel to guide the practicing oncologists of the country while dealing with HPV-associated HNSCC.

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Low prevalence of high risk human papillomavirus in normal oral mucosa by hybrid capture 2

Cited by 10 publications

References 12 publications

Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico

Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico

Role of high-risk human papillomavirus in the etiology of oral and oropharyngeal cancers in Thailand: A case–control study

Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

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