Low prevalence of knee chondrocalcinosis and its catabolic association with serum matrix metalloproteinase 3: A rural Japanese population study

Chiba, Daisuke; Tsuda, Eiichi; Sasaki, Eiji; Takahashi, Ippei; Nakaji, Shigeyuki; Ishibashi, Yasuyuki

doi:10.1111/1756-185x.13067

Cited by 4 publications

(5 citation statements)

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“…A total of 2427 articles were initially retrieved from PubMed, Embase and Scopus databases. After in‐depth review of 173 papers, 14 studies with a total of 10 995 subjects were finally included in the present study. Among these studies, 11 studies were qualified for final meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of all 14 included studies are presented in Table . There were 12 cross‐sectional studies, one prospective cohort study and one case‐control study . In these studies, knee, hip and hand joints were involved.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 12 studies were eligible for the assessment of the association between knee CC and knee OA. Among these studies, nine studies were eligible to calculate pooled OR of the prevalence of OA between the CC group and non‐CC group (Figure ). The pooled OR suggested a positive association between knee CC and knee OA (OR, 2.84; 95% CI, 2.12‐3.81; P < 0.001) with substantial heterogeneity ( I 2 = 58%; P = 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…With the exclusion of any single study, the overall OR did not vary substantially, and ranged from an OR of 2.58 (95% CI, 2.11‐3.16; P < 0.001) to 3.07 (95% CI, 2.24‐4.20; P < 0.001). Heterogeneity was substantially varied when Chiba et al’s study was excluded ( I 2 = 23, P = 0.25). We also excluded five studies with hospital‐based patients.…”

Section: Resultsmentioning

confidence: 99%

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Association between chondrocalcinosis and osteoarthritis: A systematic review and meta‐analysis

et al. 2019

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Aim To systematically examine the existing literature on the associations between chondrocalcinosis (CC) and osteoarthritis (OA) at different joints, and to quantify such associations through meta‐analysis. Methods PubMed, Embase and Scopus databases were searched through from inception to June 2017. Cohort, case‐control or cross‐sectional studies were included if they examined the association between CC and OA. Data on the odds ratios (OR) and their 95% confidence intervals (CI) of the prevalence or progression of OA between the CC group and non‐CC group with respect to the same joint were extracted. Results A total of 14 studies were identified. Twelve studies were eligible for assessing the association between knee CC and knee OA. The combined data showed a positive association between them (OR = 2.84; 95% CI, 2.12‐3.81; P < 0.001). Three studies were eligible for assessing the association between hip CC and hip OA. The data on the OR could only be extracted from one study (OR = 0.92; 95% CI, 0.68‐1.24; P = 0.59). Two studies were eligible for assessing the association between hand CC and hand OA, and the data on the OR could only be extracted from one study which reported significant associations between CC and OA at the metacarpophalangeal joint (OR = 4.75; 95% CI, 2.12‐10.64; P < 0.001) and the wrist joint (OR = 4.44; 95% CI, 3.56‐5.54; P < 0.001). Conclusion This study established a strong association between knee CC and knee OA. However, the associations between CC and OA at the hip or hand still remain controversial and warrant further study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Association between chondrocalcinosis and osteoarthritis: A systematic review and meta‐analysis

et al. 2019

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“…According to the Kellgren-Lawrence grade (KLG) 28 , single orthopaedic surgeon (DC, 12-year experience) assigned participants to the non-radiographic knee OA (Non-ROA: KLG 0–1) or radiographic knee OA (ROA: KLG 2–4) group. The intra-rater reliability (k) for determining KLG was 0.821 for the right knee and 0.805 for the left knee 29 .…”

Section: Methodsmentioning

confidence: 99%

Greater medial meniscus extrusion seen on ultrasonography indicates the risk of MRI-detected complete medial meniscus posterior root tear in a Japanese population with knee pain

Chiba

Sasaki²,

Ishibashi

2022

Sci Rep

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To elucidate the association between medial meniscus extrusion measured on ultrasonography (MMEUS) and the prevalence of medial meniscus posterior root tear detected on magnetic resonance imaging (MMPRTMRI). We recruited 127 patients (135 knees; 90 females; mean age: 64.4 ± 8.7 years old; mean BMI: 25.5 ± 3.4 kg/m2) in this cross-sectional study. All participants had medial knee pain without a knee trauma or surgery history. Knee osteoarthritis (KOA) severity was evaluated using Kellgren-Lawrence grade (KLG) scores. Patients with KLG scores 0–1 and ≥ 2 were classified in non-radiographic (non-ROA) and radiographic KOA (ROA) groups, respectively. MMEUS was measured with patients in the supine position. Based on fat-suppressed T2-weighted images, MMPRTMRI was defined as the presence of “Ghost meniscus sign” and “Cleft/truncation sign”, indicating an abnormal high signal intensity of a completely disrupted posterior root. MMEUS was compared between MMPRT+ and MMPRT– patients using a non-paired t-test. Receiver operating characteristic (ROC) curves were used to determine the optimal cut-off MMEUS to predict MMPRT+. The prevalence of MMPRT+ was 31.3% (25/80 knees) and 29.1% (16/55 knees) in the non-ROA and ROA groups. The MMEUS of MMPRT+ patients were significantly greater than that of MMPRT– patients in both the non-ROA (5.9 ± 1.4 mm vs. 4.4 ± 1.0 mm, P < 0.001) and ROA (7.8 ± 1.3 mm vs. 6.3 ± 1.3 mm, P < 0.001) groups. ROC curves demonstrated that 5-mm and 7-mm MMEUS were the optimal cut-off values in non-ROA (adjusted odds ratio: 6.280; area under the curve [AUC]: 0.809; P < 0.001) and ROA (adjusted odds ratio: 15.003; AUC: 0.797; P = 0.001) groups. In both early non-radiographic and established radiographic KOA stages, a greater MMEUS was associated with a higher MMPRTMRI prevalence.

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CPPD and Other Microcrystalline Disorders

Rosenthal

Andrés

Abhishek

et al. 2023

A Clinician's Pearls &Amp; Myths in Rheumatology

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Low prevalence of knee chondrocalcinosis and its catabolic association with serum matrix metalloproteinase 3: A rural Japanese population study

Abstract: The prevalence of CC was low in the Japanese population evaluated in this study. While CC was not correlated with self-reported knee symptoms, it was positively correlated with serum MMP-3 concentration.

Cited by 4 publications

References 34 publications

Association between chondrocalcinosis and osteoarthritis: A systematic review and meta‐analysis

Association between chondrocalcinosis and osteoarthritis: A systematic review and meta‐analysis

Greater medial meniscus extrusion seen on ultrasonography indicates the risk of MRI-detected complete medial meniscus posterior root tear in a Japanese population with knee pain

CPPD and Other Microcrystalline Disorders

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