Low Prevalence of Neurologic and Psychiatric Manifestations in Children with Gluten Sensitivity

Ruggieri, Martino; Incorpora, Gemma; Polizzi, Agata; Parano, Enrico; Spina, Massimo; Pavone, Piero

doi:10.1016/j.jpeds.2007.06.042

Cited by 72 publications

(79 citation statements)

References 32 publications

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“…The characteristics of the 15 studies included in the review are summarized in Table I; four were comparative observational cohort prospective studies, [11][12][13][14] two were comparative observational case-control studies, 15,16 and eight were descriptive crosssectional studies. [17][18][19][20][21][22][23][24][25] The included studies involved 11 772 participants.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The neurology of coeliac disease in childhood: what is the evidence? A systematic review and meta‐analysis

Lionetti

Francavilla

Pavone

et al. 2010

Develop Med Child Neuro

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METHOD We conducted a review of paediatric studies published in English assessing neurological illness in coeliac disease identified through a MEDLINE search ). Calculation of computed relative risk, odds ratio, and risk difference was performed using the fixed effect method if applicable.RESULTS Fifteen studies were analysed (11 772 participants). The meta-analysis showed that (1) the relative risk of epilepsy in individuals with coeliac disease, and of coeliac disease in individuals with epilepsy, compared with the general population, was 2.1 and 1.7, respectively, and the risk difference was close to zero, indicating that it was probably a chance association; and (2) the relative risk of headache in individuals with the disease compared with comparison groups was 3.2. In two studies, cerebellar ataxia was documented in 2.7 to 5.4% of participants; in two further studies, the risk of cerebellar dysfunction was zero. Two studies found an association between coeliac disease and peripheral neuropathy. Brain white matter lesions were recorded in two other studies. An association between autism and coeliac disease is disputed.

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Section: Study Characteristicsmentioning

confidence: 99%

“…15 In one investigation, the study population with neurological illness was aged from 8 to 23 years; however, these were prospective data on participants enrolled in the study during childhood. 14 …”

Section: Study Characteristicsmentioning

confidence: 99%

The neurology of coeliac disease in childhood: what is the evidence? A systematic review and meta‐analysis

Lionetti

Francavilla

Pavone

et al. 2010

Develop Med Child Neuro

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“…Kieslich et al (12) reported two febrile convulsion cases in their study on 75 CD patients. Ruggieri et al (2) reported only three cases of febrile convulsions among 835 CD cases. In our study, there was one patient with febrile convulsion.…”

Section: Discussionmentioning

confidence: 99%

“…Finelli et al (6) reported that 10% of patients with CD develop neurological complications. Ruggieri et al (2) stated that 15 (1.79%) of 835 patients with CD had a neuro-psychiatric disorder. In general.…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease and Associated Neurological Conditions

IŞIKAY¹,

HIZLI²

2015

Turkish J Pediatr Dis

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Objective: Celiac disease has been associated with many neurological disorders. In this report, we discuss 16 patients with both celiac disease and neurological symptoms and evaluate the overall neurological features of celiac disease in the light of the current literature to emphasize the neurological aspects of celiac disease. Material and Methods:The medical records of all patients diagnosed with celiac disease between 2010 and 2012 were reviewed.Results: Nine of these 16 cases were female while seven were male with a mean age of 10.34±3.76 years (5-16 years). The reported neurological problems of these 16 children with celiac disease were epilepsy (n=10), mental retardation (n=9), ataxia (n=3), neuropathy (n=1), headache (n=2), febrile seizure (n=1), and neurofi bromatosis type 1 (plus headache) (n=1). Conclusion:Celiac disease may accompany many different neurological conditions. These disorders can share some symptoms such as associated anemia, short stature, and chronic gastrointestinal complaints and the diagnosis of celiac disease may be delayed among patients with neurological disease.

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“…Recently, Boskovic and Stankovic reported a 15-year-old girl affected by CD, who presented with an acute sensory-motor demyelinating peripheral polyneuropathy after accidental reintroduction of gluten in her diet (2) . Ruggieri et al reported the long term follow-up of a girl (0.1%) out of 835 children with CD; developing acute demyelinating neuropathy after accidental reintroduction of gluten in her diet, with rapid disappearance of symptoms on a gluten-free regimen (17) . Similar with our study Cakir et al tried to investigate whether early neurological abnormalities may be detected in children with CD and they reported two peripheral polyneuropathy documented with electromyography, and one prolonged latencies in somatosensory evoked potential in 27 children with CD and receiving gluten free diet (4) .…”

Section: Discussionmentioning

confidence: 99%

Peripheral Neuropathy Electrophysiological Screening in Children With Celiac Disease

Işıkay

Kocamaz

et al. 2015

Arq. Gastroenterol.

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-Background -The involvement of the peripheral nervous system in children with celiac disease is particularly rare. Objective -The aim of this study was to assess the need for neurophysiological testing in celiac disease patients without neurological symptoms in order to detect early subclinical neuropathy and its possible correlations with clinical and demographic characteristics. Methods -Two hundred and twenty consecutive children with celiac disease were screened for neurological symptoms and signs, and those without symptoms or signs were included. Also, patients with comorbidities associated with peripheral neuropathy or a history of neurological disease were excluded. The remaining 167 asymptomatic patients as well as 100 control cases were tested electro-physiologically for peripheral nervous system diseases. Motor nerve conduction studies, including F-waves, were performed for the median, ulnar, peroneal, and tibial nerves, and sensory nerve conduction studies were performed for the median, ulnar, and sural nerves with H reflex of the soleus muscle unilaterally. All studies were carried out using surface recording electrodes. Normative values established in our laboratory were used. Results -Evidence for subclinical neuropathy was not determined with electrophysiological studies in any of the participants. Conclusion -In this highly selective celiac disease group without any signs, symptoms as well as the predisposing factors for polyneuropathy, we did not determine any cases with neuropathy. With these results we can conclude that in asymptomatic cases with celiac disease electrophysiological studies are not necessary. However, larger studies with the electrophysiological studies performed at different stages of disease at follow-ups are warranted. HEADINGS -Celiac disease. Peripheral nervous system diseases. Electrophysiological phenomena. Child.Declared conflict of interest of all authors: none Disclosure of funding: no funding received

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Low Prevalence of Neurologic and Psychiatric Manifestations in Children with Gluten Sensitivity

Cited by 72 publications

References 32 publications

The neurology of coeliac disease in childhood: what is the evidence? A systematic review and meta‐analysis

The neurology of coeliac disease in childhood: what is the evidence? A systematic review and meta‐analysis

Celiac Disease and Associated Neurological Conditions

Peripheral Neuropathy Electrophysiological Screening in Children With Celiac Disease

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