Low protein fish vs low protein animal diet enhances the propensity for stroke in stroke-prone/SHR.

The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relatively low cost, are highly suitable for the investigation of cerebral ischemia and have been widely employed for this purpose. We critically examine and summarize several rodent models of transient global ischemia, resulting in selective neuronal injury within vulnerable brain regions, and focal ischemia, typically giving rise to localized brain infarction. We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury.

show abstract

“…110 Interestingly, Tobian et al 111 have shown a dramatic 98% reduction in mortality and complete prevention of Perm.…”

mentioning

confidence: 99%

Rodent models of cerebral ischemia.

Ginsberg

Busto

1989

Stroke

571

283

View full text Add to dashboard Cite

show abstract

“…investigators 4 attributed the higher incidence of stroke produced by the Funahashi-SP diet to the fact that the protein content was not only low but was derived from fish as opposed to animal or plant material. This latter hypothesis, however, has never been confirmed and is further complicated by the fact that elevating the fish, plant, or animal protein levels in the Japanese diet protects against stroke.…”

mentioning

confidence: 99%

Hemorrhagic stroke development in spontaneously hypertensive rats fed a North American, Japanese-style diet.

Smeda

1989

Stroke

View full text Add to dashboard Cite

The purpose of my study was to assess a North American, Japanese-style diet commercially available from Zeigler Brothers (Gardners, Pennsylvania) with respect to the initiation of stroke development in 34 stroke-prone spontaneously hypertensive rats (spSHR) and in 14 strokeresistant spontaneously hypertensive rats (srSHR). Nineteen spSHR fed the diet containing 4% NaCl and 0.75% K + (low-K + diet) from weaning had an accelerated rate of stroke development (mean±SEM age at death 15.3±0.5 weeks). The same diet containing 2.11% K + (high-K + diet) increased the mean lifespan of 15 spSHR by 39% but did not prevent stroke. The locations of hemorrhagic lesions were similar in the groups of spSHR fed high-and low-K + diets, being nearly equally divided between the territories of the anterior, posterior, and middle cerebral arteries. The 14 srSHR fed the Iow-K + diet exhibited 50% mortality at 66 weeks of age. However, in the srSHR fed the Iow-K + diet, death did not result from hemorrhagic stroke. The differing incidence of stroke between the spSHR fed high-and low-K + diets and between spSHR and srSHR fed the low-K + diet could not be explained on the basis of differing blood pressures. Compared with spSHR fed the low-K + diet, both srSHR fed the low-K + diet and spSHR fed the high-K* diet exhibited higher drinking and urine excretion rates and elevated plasma K + levels. My study indicates the availability of a commercial North American diet that produces a predictable high incidence of stroke within a compressed time period in spSHR but not in srSHR. This diet would be useful in studies attempting to determine the events preceding and leading to the development of stroke and in determining the genetic factors responsible for stroke resistance.

show abstract

“…85 Several studies have demonstrated the importance of diet in the etiology of stroke in SHRSP; they developed strokes only if fed a specific low-protein fish meal diet. 88 Tobian et al 89 observed that increased dietary K + greatly reduced strokes in SHRSP even though there was little or no effect on blood pressure, the implication being that K + has an effect on blood vessels independent of its effect on blood pressure. Tobian et al pointed out that the dietary intake of K + is lowest among blacks in the southeastern US and in certain parts of Japan; areas of Japan where apples (high in K + ) comprise an important dietary staple have a much lower incidence of stroke.…”

mentioning

confidence: 99%