Low radiation iridium 191m radionuclide angiography: Detection and quantitation of left-to-right shunts in infants

Treves, S. Ted; Fyler, Donald C.; Fujii, Alan M.; Kuruc, Alvin

doi:10.1016/s0022-3476(82)80119-4

Cited by 22 publications

(6 citation statements)

References 7 publications

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“…This vascular plexus finally loses many of its connections so that the bronchial arteries and pulmonary arteries are mostly separate at their proximal aspects, while some of the residual distal connections still remain. This would explain the bronchial and pulmonary connections that have been described in the normal lung .…”

Section: Resultsmentioning

confidence: 79%

“…Radionuclide angiography can suggest the presence of a left‐to‐right shunt and thus obviate the need for an invasive procedure , but it does not localise the anatomic site of left‐to‐right shunting . Radionuclide angiography and the pulmonary‐to‐systemic blood flow ratio on cardiac catheterisation are considered to be a good qualitative measure of left‐to‐right shunts.…”

Section: Resultsmentioning

confidence: 99%

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A literature review of systemic to pulmonary collaterals in preterm infants to emphasise their existence and clinical importance

et al. 2018

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

A literature review of systemic to pulmonary collaterals in preterm infants to emphasise their existence and clinical importance

et al. 2018

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“…The ultra-short lived daughter was shown to be appropriate for evaluation of intracardiac shunts in premature babies, children and adults [196,197] Packard et al [194,195] Brihaye et al [191] Issachar et al [192] prototype system was developed in a collaboration between the Cyclotron Research Center of the University of Liege, Belgium, and the Nuclear Medicine Group at ORNL. The system was used to evaluate left ventricular ejection function and regional wall motion of the heart of over 600 patients.…”

Section: Smentioning

confidence: 99%

Radionuclide Generators

Lambrecht

Tomiyoshi

Sekine³

1997

Radiochimica Acta

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The present status and future directions of research and development on radionuclide generator technology are reported. The recent interest to develop double-neutron capture reactions for production of in vivo generators; neutron rich nuclides for radioimmunotherapeutic pharmaceuticals; and advances with ultrashort lived generators is highlighted. Emphasis is focused on: production of the parent radionuclide; the selection and the evaluation of support materials and eluents with respect to the resultant radiochemical yield of the daughter, and the breakthrough of the radionuclide parent; and, the uses of radionuclide generators in radiopharmaceutical chemistry, biomedical and industrial applications. The 62 Zn -62 Cu, ^Ni -""Cu, ,03m Rh -• ,03 Rh, ,88 W -• ,88 Re and the 225 Ac -22, Fr -2l3 Bi generators are predicted to be emphasized for future development.

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“…> ten half-lives) following elution of the 191mIr daughter. The first generator provided 191mIr for intravenous administration [102] and another system was used for quantification of cardiac shunts in children [103,104] and evaluation of ventricular function in adults [105]. This early prototype used an Os(IV) species and the AG MP1 organic anion exchange resin eluted with 0.9% saline at pH 1 saline [106].…”

Section: The Mercury-195m/gold-195m Generatormentioning

confidence: 99%

The continuing important role of radionuclide generator systems for nuclear medicine

1994

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In this review, the continuing importance and status of development of radionuclide generator systems for nuclear medicine are discussed. Radioisotope costs and availability are two important factors, and both nuclear reactors and accelerator facilities are required for production of the parent radioisotopes. Radionuclide generator research is currently focused on the development of generators which provide radioisotopes for positron emission tomography (PET) applications and daughter radioisotopes for various therapeutic applications which decay primarily by particle emission. Generator research continues to be influenced by developments and requirements of complementary technologies, such as the increasing availability of PET. In addition, the availability of a wide spectrum of tumor-specific antibodies, fragments, and peptides for radioimmunodiagnosis and radioimmunotherapy has stimulated the need for generator-derived radioisotopes. The advantages of treatment of arthritis of the synovial joints with radioactive particles (radiation synovectomy) may be expected to be of increasing importance as the elderly population increases, and many of these agents are prepared using generator-derived radioisotopes such as yttrium-90 and rhenium-188. Therapeutic use of the "in vivo generator" is a new approach, where the less radiotoxic parent radioisotope is used to prepare tissue-specific therapeutic agents. Following in vivo site localization, decay of the parent provides the daughter for therapy at the target site. The principal foundation of most diagnostic agents will continue to require technetium-99m from the molybdenum-99/technetium-99m ("Moly") generator. With the limited availability of nuclear reactors and facilities necessary for production and processing of fission 99mTc and the significant issues and problems associated with radioactive waste processing, however, the possibility of utilizing lower specific activity 99Mo produced from neutron activation of enriched 98Mo may become practical in the future.

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Low radiation iridium 191m radionuclide angiography: Detection and quantitation of left-to-right shunts in infants

Cited by 22 publications

References 7 publications

A literature review of systemic to pulmonary collaterals in preterm infants to emphasise their existence and clinical importance

A literature review of systemic to pulmonary collaterals in preterm infants to emphasise their existence and clinical importance

Radionuclide Generators

The continuing important role of radionuclide generator systems for nuclear medicine

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