Incidence rate of mental illness is increasing year by year with the development of city. The amount of modern medical data is huge and complex. In many cases, it is difficult to realize the rational allocation of resources, which puts forward an urgent demand for the artificial intelligence of modern medicine and brings great pressure to the development of the medical industry. The purpose of this study is to develop and construct a grey correlation analysis and related drug evaluation system of mental diseases based on deep convolution neural network. The establishment of the system can effectively improve the automation and intelligence of modern psychiatric treatment process. In this article, the grey correlation analysis of patient data is carried out, and then, the optimized deep convolution neural network is constructed. Combined with the medical knowledge base, the analysis of disease results is realized, and on this basis, the efficacy of related drugs in the treatment of mental diseases is evaluated. The results show that the advantage of the deep convolution neural network system is to effectively improve the induction rate. What’s more, compared with other algorithms, this algorithm has higher accuracy and efficiency. It improves the comprehensiveness and informatization of disease screening methods, improves the accuracy of screening, reduces the consumption of doctors’ human resources, and provides a theoretical basis for the digitization of the medical industry in the future.