Low-Rank Tensor Fusion for Enhanced Deep Learning-Based Multimodal Brain Age Estimation

Abstract

Background/Objectives: A multimodal brain age estimation model could provide enhanced insights into brain aging. However, effectively integrating multimodal neuroimaging data to enhance the accuracy of brain age estimation remains a challenging task. Methods: In this study, we developed an innovative data fusion technique employing a low-rank tensor fusion algorithm, tailored specifically for deep learning-based frameworks aimed at brain age estimation. Specifically, we utilized structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), and magnetoencephalography (MEG) to extract spatial–temporal brain features with different properties. These features were fused using the low-rank tensor algorithm and employed as predictors for estimating brain age. Results: Our prediction model achieved a desirable prediction accuracy on the independent test samples, demonstrating its robust performance. Conclusions: The results of our study suggest that the low-rank tensor fusion algorithm has the potential to effectively integrate multimodal data into deep learning frameworks for estimating brain age.