Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer

Halbert, Chanita Hughes; Kessler, Lisa; Stopfer, Jill E.; Domchek, Susan M.; Wileyto, E. Paul

doi:10.1097/01.gim.0000237719.37908.54

Cited by 67 publications

(97 citation statements)

References 35 publications

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“…We adapted a Likert style item from our previous research (Halbert et al 2006) to measure how concerned respondents were about diseases for which FHH is a risk factor. In this study, we focused on concern about cancer and heart disease because these conditions are leading causes of morbidity and mortality nationally and among SC residents (South Carolina Department of Health and Environmental Control).…”

Section: Concern About Cancermentioning

confidence: 99%

Social determinants of family health history collection

et al. 2015

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Family health history (FHH) is the most basic form of genomic information. Although public health efforts have been made to promote FHH collection, empirical data on the extent to which community residents in rural areas actively collect FHH is limited. Therefore, we examined rates of FHH collection in a community-based sample of South Carolina residents. We conducted a structured telephone survey in a random sample of black and white South Carolina residents. Respondents were asked if they had ever actively collected FHH from relatives using an item developed by the Centers for Disease Control and Prevention. Overall, 42 % of respondents reported that they had actively collected their FHH. Blacks were significantly more likely than whites to have collected their FHH in bivariate analysis, but race did not have a significant association with FHH collection in the multivariate model (OR=1.36, 95 % CI=0.79, 2.35, p=0.26). The likelihood of collecting FHH was increased among respondents whose last medical visit occurred in the past year compared to those whose last medical visit was more than 1 year ago (OR=2.00, 95 % CI=1.12, 3.56, p=0.02). In addition, older respondents had a reduced likelihood of collecting their FHH (OR=0.69, 95 % CI=0.53, 0.90, p=.01). Lastly, women were about twice as likely as men to have collected their FHH (OR=1.83, 95 % CI=1.12, 2.99, p=0.02). Greater efforts are needed to increase the collection of FHH information; these efforts may need to target men, the elderly, and individuals who have not had a recent medical visit.

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Section: Concern About Cancermentioning

confidence: 99%

Social determinants of family health history collection

et al. 2015

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“…A number of small prevalence surveys in Black women have yielded varying results with respect to BRCA prevalence and penetrance specific to AA women Frank et al 2002;Gao et al 2000;Haffty et al 2005;John et al 2007;Kanaan et al 2003;Malone et al 2006;Mefford et al 1999;Nanda et al 2005;Olopade et al 2003;Pal et al 2004Pal et al , 2008Panguluri et al 1999;Pegoraro et al 2003;Shen et al 2000). This lack of knowledge is perpetuated by low rates of participation by AA women in clinical and research BRCA genetic counseling and testing (Armstrong et al 2005;Halbert et al 2006). Previous studies have examined the various aspects which influence the uptake of genetic counseling and testing for inherited breast cancer in Black women.…”

Section: Introductionmentioning

confidence: 99%

Updating and refining a study brochure for a cancer registry-based study of BRCA mutations among young African American breast cancer patients: lessons learned

Vadaparampil

Pal

2010

J Community Genet

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The aim of the present study was to update, refine, and evaluate a study brochure to promote participation in a population-based study of BRCA mutations among AA women with a personal history of early-onset breast cancer. A multi-step approach was used to develop this brochure and included: (1) feedback from community members (through a Community Advisory Panel (CAP)) to develop and refine the study brochure, (2) pilot testing of materials with the target audience, and (3) review of pilot testing results with the CAP. Based on the feedback received at each step, the study brochure was refined. In phase 1, the major changes included emphasizing the concept of leaving a legacy and family, using the terms Black and women of color, and use of patient vignettes and photos. In phase 2, attraction and cultural acceptability were identified as two areas for improvement in the study brochure. These results demonstrate that involvement of community members and target study population in the development of a study-specific brochure can provide invaluable feedback to optimize recruitment strategies. This approach can be readily adapted to develop study recruitment materials for individuals from a variety of cultural and ethnic backgrounds.

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“…Although women with a personal history of breast cancer have a 0.56% to 1.0% risk per year of developing a second primary breast cancer, women who carry BRCA1/2 mutations have a substantially higher risk, approaching a 50% lifetime risk (6)(7)(8)(9). Breast cancer risk perceptions are important to utilization of genetic testing for BRCA1/2 mutations (10), which may be low among African American women (11). Prior research has shown that African American women without a personal history of breast cancer may not believe that they have an increased risk for developing disease, although known risk factors (e.g., family history of breast cancer in a first-degree relative) are present (12).…”

Section: Introductionmentioning

confidence: 99%

Sociocultural Predictors of Breast Cancer Risk Perceptions in African American Breast Cancer Survivors

Brewster¹,

Wileyto²,

Kessler³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although African American breast cancer survivors are at increased risk for developing breast cancer again, empirical data are not available on breast cancer risk perceptions in these women. This study characterized perceived risk of developing breast cancer in African American breast cancer survivors at risk for having a BRCA1 or BRCA1 (BRCA1/2) mutation and identified factors having significant independent associations with risk perceptions. Participants were 95 African American breast cancer survivors at an increased risk for having a BRCA1/2 mutation. Risk perceptions and sociodemographic, clinical, treatment, and sociocultural factors were collected during a structured telephone interview. Most women reported that they had the same or lower risk of developing breast cancer again compared with other women (53%); however, a substantial minority of women (47%) reported that they had a higher or much higher risk. Factors having significant independent associations with heightened risk perceptions included having a z10% prior probability of having a BRCA1/2 mutation [odds ratio (OR), 2.91; 95% confidence interval (95% CI), 1.09-7.72; P = 0.03] and more years of formal education (OR, 2.74; 95% CI, 1.02-7.36; P = 0.05). In addition, women who thought about the past a lot were three times more likely to report heightened risk perceptions compared with those who did not think about the past a lot (OR, 3.72; 95% CI, 1.45-9.57; P = 0.01). These results suggest that it may be important to ensure adequate risk comprehension among African American women as part of genetic counseling for inherited breast-ovarian cancer risk. Discussion of risk perceptions within the context of existing beliefs and values may facilitate this process. (Cancer Epidemiol Biomarkers Prev 2007;16(2):244 -8)

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Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer

Cited by 67 publications

References 35 publications

Social determinants of family health history collection

Social determinants of family health history collection

Updating and refining a study brochure for a cancer registry-based study of BRCA mutations among young African American breast cancer patients: lessons learned

Sociocultural Predictors of Breast Cancer Risk Perceptions in African American Breast Cancer Survivors

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