Low Risk for Tuberculosis in a Regional Pediatric Hospital: Nine-Year Study of Community Rates and the Mandatory Employee Tuberculin Skin-Test Program

Christie, C. D. C.; Constantinou, Panayiota; Marx, Mary L.; Willke, Mary Jane; Marot, Kathleen; Méndez, Fernando L.; Donovan, James; Thole, Julia

doi:10.2307/30143436

Cited by 11 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several longitudinal studies have demonstrated a positive association between TST response and subsequent risk of active TB. 9,10 Randomized trials have shown that treatment of latent infection, diagnosed on the basis of positive TST, reduces the risk of active TB. This experimental evidence has lead to the policy of tuberculin testing and treatment of latent TB infection.…”

Section: Tuberculin Skin Testmentioning

confidence: 99%

Diagnosis of latent tuberculosis infection: The potential role of new technologies

Kunst

2006

Respiratory Medicine

View full text Add to dashboard Cite

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. TB control programmes need improvement in the diagnosis of latent TB infection. The tuberculin skin test (TST) is far from a 'gold' standard as it often gives false results. Interferon-gamma assays are newly available tests to detect latent TB infection, but they are currently not routinely used. They are based on immune responses to purified protein derivative (PPD) or to region of difference 1 (RD1) specific antigens. Assays based on RD-1 specific antigens perform better than both PPD based assays and TST. They correlate with TB exposure and are less likely to give false results in non-tuberculous mycobacterial disease, Bacille Calmette-Guerin (BCG) vaccination and immunosuppression. More accurate diagnosis of latent TB infection with RD-1 specific antigen based interferon-gamma assays may allow targeting of chemoprophylaxis to reduce the burden of active TB while decreasing wastage of health care resources due to false results associated with TST. However, further research and development is required to verify that new tests can predict the risk of later development of active TB and to make it feasible to perform these tests in a reproducible fashion at low cost, particularly in developing countries.

show abstract

Section: Tuberculin Skin Testmentioning

confidence: 99%

Diagnosis of latent tuberculosis infection: The potential role of new technologies

Kunst

2006

Respiratory Medicine

View full text Add to dashboard Cite

show abstract

“…These data suggest that TB is a significant hazard for HCWs. By contrast, Christie et al 15 found low tuberculin conversion rates and only a 0.3% rate of active TB among HCWs with documented conversions during 9 years of follow-up in a pediatric hospital in Cincinnati, Ohio.…”

Section: Discussionmentioning

confidence: 86%

Survey of Tuberculin Skin Test Positivity Among Israeli Pediatric Hospital Workers

Finkelstein

Elenberg

Chodick

et al. 2004

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

“…Although there is considerable evidence that workers who provide direct patient care are at greater risk for TB infection than workers who did not provide direct patient care [Mikol et al, 1952;Beck-Sagué et al, 1992;Dooley et al, 1992;Pearson et al, 1992;Zaza et al, 1995;Rullan et al, 1996;Boudreau et al, 1997;Behrman and Shofer, 1998], the results among studies are inconsistent. One explanation for the differences may be variation in the admission rates of TB patients [Bailey et al, 1995;Christie et al, 1998]. In institutions with fewer than 10 admissions for TB annually, the annual worker risk of infection was less than 0.2%, as compared to institutions such as the hospital we studied, with more than 200 admissions for TB annually and an annual worker infection rate between 1 and 10% [Menzies et al, 1995].…”

Section: Discussionmentioning

confidence: 95%

Historical risks of tuberculin skin test conversion among non‐physician staff at a large urban hospital

Miller

Tepper

Sieber

2002

American J Industrial Med

View full text Add to dashboard Cite

Background Nosocomial transmission of Mycobacterium tuberculosis among workers at a 1000‐bed inner‐city hospital led to an extensive evaluation of this risk among workers with potential exposure to TB patients or laboratory specimens. Methods Retrospective cohort study to determine the incidence and risk of tuberculin skin test (TST) conversions among workers employed 1/1/90 to 9/30/92. Results Personal, community, and occupational risk factors were evaluated in 2,362 workers with potential M. tuberculosis exposure and 886 workers with no known exposure. The 33‐month cumulative rate of TST conversion was 5.8% for potentially exposed workers and 2.0% for controls (RR 3.6; 95% CI; 2.2–5.8). Among workers with potential M. tuberculosis exposure, statistically significantly elevated risks were found for nurses, laboratory technicians, pharmacy workers, phlebotomists, housekeepers, clerks, emergency room workers, and emergency responders. Conclusions Workers with patient contact and those employed in certain occupational groups were at increased risk for occupational M. tuberculosis infection. Am. J. Ind. Med. 42:228–235, 2002. Published 2002 Wiley‐Liss, Inc.

show abstract

Low Risk for Tuberculosis in a Regional Pediatric Hospital: Nine-Year Study of Community Rates and the Mandatory Employee Tuberculin Skin-Test Program

Cited by 11 publications

References 29 publications

Diagnosis of latent tuberculosis infection: The potential role of new technologies

Diagnosis of latent tuberculosis infection: The potential role of new technologies

Survey of Tuberculin Skin Test Positivity Among Israeli Pediatric Hospital Workers

Historical risks of tuberculin skin test conversion among non‐physician staff at a large urban hospital

Contact Info

Product

Resources

About