2011
DOI: 10.1038/ijo.2011.122
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Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden

Abstract: Objective Type 1 diabetes and obesity has increased in childhood. We therefore tested the hypothesis that type 1 diabetes HLA-DQ risk genotypes may be associated with an increased body mass index (BMI). Design The type 1 diabetes high risk HLA-DQ A1*05:01-B1*02:01/A1*03:01-B1*03:02 genotype along with lower risk DQ genotypes were determined at the time of clinical onset by PCR and hybridization with allele-specific probes. Body mass index was determined after diabetes was stabilized. Subjects A total of 24… Show more

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Cited by 52 publications
(69 citation statements)
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“…Moreover, despite a large body of evidence implicating a role for the IGF1/IGFBP3 system in the development of T1D (1,2,3,4,5,7,11,12), there is only one study on circulating IGF1 and IGFBP3 concentrations in prediabetic children with early signs of b-cell autoimmunity, i.e. positivity for diabetes-associated autoantibodies (24). That study did not find any difference between the level of IGF1 or IGFBP3 in subjects developing autoantibodies compared to those without autoantibodies (24).…”
Section: Introductionmentioning
confidence: 75%
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“…Moreover, despite a large body of evidence implicating a role for the IGF1/IGFBP3 system in the development of T1D (1,2,3,4,5,7,11,12), there is only one study on circulating IGF1 and IGFBP3 concentrations in prediabetic children with early signs of b-cell autoimmunity, i.e. positivity for diabetes-associated autoantibodies (24). That study did not find any difference between the level of IGF1 or IGFBP3 in subjects developing autoantibodies compared to those without autoantibodies (24).…”
Section: Introductionmentioning
confidence: 75%
“…In only one relevant study (24), the IGF1 and IGFBP3 concentrations were compared at certain time points irrespectively of the time of seroconversion, whereas our study looked at the rate of IGF1 and IGFBP3 increments before the time of seroconversion. This approach evaluates more directly the role of IGF1 and IGFBP3 in the process of autoimmunity development.…”
Section: Discussionmentioning
confidence: 99%
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“…Data from the Swedish Better Diabetes Diagnosis (BDD) study representing HLA-DQ genotyping and islet autoantibody analysis from more than 3,000 patients diagnosed with T1D during May 2005 -August 2010 61 . ZnT8 autoantibodies were against the arginine (R), tryptophan (W) or glutamine (Q) at position 325 in the translated protein.…”
Section: One or Several Islet Autoantibodies 93mentioning
confidence: 99%
“…A total of 2700 incident diabetes patients o18 years at diagnosis were collected between 2005 and 2009 from 40 pediatric clinics in Sweden for the BDD study. 28 Only patients diagnosed with T1D and with all parents and grandparents born in Scandinavia are included in this study.…”
Section: Swedish Childhood Study (Sv2)mentioning
confidence: 99%